HK1000098A1 - Acridinium esters and method for detection of an analyte using acridinium esters and liposomes - Google Patents
Acridinium esters and method for detection of an analyte using acridinium esters and liposomesInfo
- Publication number
- HK1000098A1 HK1000098A1 HK97101553A HK97101553A HK1000098A1 HK 1000098 A1 HK1000098 A1 HK 1000098A1 HK 97101553 A HK97101553 A HK 97101553A HK 97101553 A HK97101553 A HK 97101553A HK 1000098 A1 HK1000098 A1 HK 1000098A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- acridinium esters
- analyte
- liposomes
- detection
- acridinium
- Prior art date
Links
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 2
- 239000012491 analyte Substances 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 239000002502 liposome Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22663988A | 1988-08-01 | 1988-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1000098A1 true HK1000098A1 (en) | 1997-11-21 |
Family
ID=22849773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK97101553A HK1000098A1 (en) | 1988-08-01 | 1997-07-11 | Acridinium esters and method for detection of an analyte using acridinium esters and liposomes |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0353971B1 (xx) |
| JP (2) | JP2601347B2 (xx) |
| AU (2) | AU634716B2 (xx) |
| CA (1) | CA1339490C (xx) |
| DE (1) | DE68925603T2 (xx) |
| HK (1) | HK1000098A1 (xx) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656426A (en) * | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
| CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
| US5155022A (en) * | 1991-02-08 | 1992-10-13 | Becton, Dickinson And Company | Assay for lyme disease |
| US5436155A (en) * | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
| US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| EP0761652A1 (en) * | 1995-08-01 | 1997-03-12 | Mochida Pharmaceutical Co., Ltd. | Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof |
| ES2320055T3 (es) * | 1998-08-11 | 2009-05-18 | Siemens Healthcare Diagnostics Inc. | Compuestos de uso acridino quiminolumicentes en el infrarrojo cercano y sus usos. |
| US6723851B2 (en) * | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
| JP4976412B2 (ja) | 2005-12-01 | 2012-07-18 | ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー | エンドセリン、エンドセリンアゴニスト及びアドレノメジュリンアンタゴニストによる危篤患者の診断及び治療のための方法 |
| ES2392900T3 (es) * | 2006-10-13 | 2012-12-14 | Siemens Healthcare Diagnostics Inc. | Ésteres de acridinio estables con emisión de luz rápida |
| EP3553084B1 (en) | 2011-11-16 | 2022-11-16 | AdrenoMed AG | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
| US9402900B2 (en) | 2011-11-16 | 2016-08-02 | Adrenomed Ag | Methods of modulating adrenomedullin by administering an anti-adrenomedullin (ADM) antibody |
| RS55804B1 (sr) | 2011-11-16 | 2017-08-31 | Sphingotec Gmbh | Testovi za adrenomedulin i metodi za određivanje zrelog adrenomedulina |
| HUE042477T2 (hu) | 2011-11-16 | 2019-07-29 | Adrenomed Ag | Anti-adrenomedullin (ADM) ellenanyag vagy anti-ADM ellenanyag-fragmens vagy anti-ADM nem-Ig váz krónikus vagy akut betegségben szenvedõ páciens folyadékegyensúlyának szabályozására |
| EP2594587B1 (en) | 2011-11-16 | 2014-05-21 | AdrenoMed AG | Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig protein scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition |
| MX355482B (es) | 2011-11-16 | 2018-04-19 | Adrenomed Ag | Anticuerpo anti - adrenomedulina (adm) o fragmento de anticuerpo anti - adm o un andamio no ig anti - adm para usarse en terapia. |
| CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
| CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
| CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
| JP6392762B2 (ja) | 2012-10-02 | 2018-09-19 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 女性対象において癌になるリスクの予測を補助するための方法 |
| DK2904403T3 (en) | 2012-10-02 | 2018-07-16 | Sphingotec Gmbh | PROCEDURE FOR DIAGNOSTICATION OR MONITORING OF Kidney Function or Diagnosis of Kidney Function |
| RU2677895C2 (ru) | 2013-01-08 | 2019-01-22 | Сфинготек Гмбх | Уровни гормона роста натощак в качестве прогностического маркера сердечно-сосудистого риска |
| SG11201505227YA (en) | 2013-01-08 | 2015-08-28 | Sphingotec Gmbh | A method for predicting the risk of getting cancer or diagnosing cancer in a subject |
| WO2015101596A2 (en) | 2013-12-30 | 2015-07-09 | Oncoprevent Gmbh | Neurokinin-1 receptor antagonists for use in a method of prevention of cancer |
| EP3002589A1 (en) | 2014-10-01 | 2016-04-06 | sphingotec GmbH | A method for stratifying a female subject for hormone replacement therapy |
| JP6760947B2 (ja) | 2015-02-27 | 2020-09-23 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 対象における肥満リスクの予測方法 |
| SG11201809252YA (en) | 2016-04-21 | 2018-11-29 | Sphingotec Therapeutics Gmbh | Methods for determining dpp3 and therapeutic methods |
| JP7191813B2 (ja) | 2016-07-08 | 2022-12-19 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 急性心不全に罹患している対象におけるうっ血を評価するためのアドレノメデュリン |
| EP3309550A1 (en) | 2016-10-12 | 2018-04-18 | sphingotec GmbH | Method for the detection of apolipoprotein e4 |
| MX2019007107A (es) | 2016-12-16 | 2019-10-21 | Adrenomed Ag | Anticuerpo anti-adrenomedulina (adm) o fragmento de anticuerpo anti-adm o supercontigo sin ig anti-adm para su uso en intervencion y terapia de congestion en un paciente con necesidad del mismo. |
| EP3339324A1 (en) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
| US20200182885A1 (en) | 2017-05-30 | 2020-06-11 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfuntion |
| US11530276B2 (en) | 2017-10-25 | 2022-12-20 | 4TEEN4 Pharmaceuticals GmbH | DPP3 binder directed to and binding to specific DPP3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress |
| CN111902721A (zh) | 2018-02-08 | 2020-11-06 | 斯弗因高泰克有限公司 | 用于诊断和/或预测痴呆症的肾上腺髓质素和抗肾上腺髓质素结合物在治疗或预防痴呆症中的应用 |
| EP3897686A2 (en) | 2018-12-21 | 2021-10-27 | 4TEEN4 Pharmaceuticals GmbH | Therapy guidance and/or therapy monitoring for a treatment with angiotensin-receptor-agonist and/or a precursor thereof |
| WO2021028582A1 (en) | 2019-08-15 | 2021-02-18 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction in pediatric patients |
| JP2022546061A (ja) | 2019-08-30 | 2022-11-02 | ４ティーン４ ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ショック症治療のための治療法の誘導および／または治療法の監視 |
| EP3871689A1 (en) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anti-adm-antibodies binding to the free n-terminus for accelerated transition of adm-gly to bio-adm in patients with adm-gly/ bio-adm ratio above a threshold and combination with vitamin c |
| MX2022010672A (es) | 2020-02-27 | 2022-09-23 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 para la guia, monitoreo y estratificacion terapeutica de anticuerpos nt-adm en pacientes con choque. |
| KR20220145897A (ko) | 2020-02-27 | 2022-10-31 | 아드레노메드 아게 | 쇼크의 치료 또는 예방에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드 |
| US20230112563A1 (en) * | 2020-03-04 | 2023-04-13 | Siemens Healthcare Diagnostics Inc. | Compositions and methods of using modified liposomes |
| CN115136006A (zh) * | 2020-03-04 | 2022-09-30 | 美国西门子医学诊断股份有限公司 | 放大免疫测定信号的方法 |
| US20230213519A1 (en) | 2020-03-16 | 2023-07-06 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 in patients infected with coronavirus |
| EP3922993A1 (en) | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 in patients infected with coronavirus |
| BR112022017890A2 (pt) | 2020-03-16 | 2022-11-01 | Sphingotec Gmbh | Proadrenomedulina ou fragmento da mesma em pacientes infectados com coronavírus e tratamentos com ligante contra adrenomedulina |
| EP4023218A1 (en) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Combination therapy for patients having acute and/or persistent dyspnea |
| CA3218162A1 (en) | 2021-05-07 | 2022-11-10 | Deborah BERGMANN | Mature adrenomedullin for therapy stratification of corticosteroids in critically ill patients |
| WO2024023368A1 (en) | 2022-07-29 | 2024-02-01 | 4TEEN4 Pharmaceuticals GmbH | Prediction of an increase of dpp3 in a patient with septic shock |
| WO2024126793A1 (en) | 2022-12-15 | 2024-06-20 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 inhibitor for improvement of pulmonary function in critically ill patients |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
| GB2112779B (en) * | 1981-12-11 | 1986-10-15 | Welsh Nat School Med | Aryl acridinium esters as luminescent labelling materials |
| DE3645292C2 (de) * | 1986-08-22 | 1997-12-11 | Hoechst Ag | Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
-
1989
- 1989-07-27 AU AU39033/89A patent/AU634716B2/en not_active Ceased
- 1989-07-31 CA CA000607098A patent/CA1339490C/en not_active Expired - Fee Related
- 1989-07-31 JP JP1199178A patent/JP2601347B2/ja not_active Expired - Lifetime
- 1989-07-31 DE DE68925603T patent/DE68925603T2/de not_active Expired - Fee Related
- 1989-07-31 EP EP89307752A patent/EP0353971B1/en not_active Expired - Lifetime
-
1993
- 1993-01-27 AU AU32034/93A patent/AU654754B2/en not_active Ceased
-
1996
- 1996-07-09 JP JP8179488A patent/JP2822320B2/ja not_active Expired - Lifetime
-
1997
- 1997-07-11 HK HK97101553A patent/HK1000098A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0296567A (ja) | 1990-04-09 |
| AU634716B2 (en) | 1993-03-04 |
| DE68925603D1 (de) | 1996-03-21 |
| JP2601347B2 (ja) | 1997-04-16 |
| EP0353971A2 (en) | 1990-02-07 |
| AU654754B2 (en) | 1994-11-17 |
| JP2822320B2 (ja) | 1998-11-11 |
| AU3203493A (en) | 1993-04-01 |
| EP0353971B1 (en) | 1996-02-07 |
| EP0353971A3 (en) | 1990-10-10 |
| DE68925603T2 (de) | 1996-09-26 |
| CA1339490C (en) | 1997-10-07 |
| JPH0925422A (ja) | 1997-01-28 |
| AU3903389A (en) | 1990-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |