GT199700061A - Procedimiento para la obtencion de "compuestos antipicornavirales y metodos para su uso y preparacion". - Google Patents

Procedimiento para la obtencion de "compuestos antipicornavirales y metodos para su uso y preparacion".

Info

Publication number
GT199700061A
GT199700061A GT199700061A GT199700061A GT199700061A GT 199700061 A GT199700061 A GT 199700061A GT 199700061 A GT199700061 A GT 199700061A GT 199700061 A GT199700061 A GT 199700061A GT 199700061 A GT199700061 A GT 199700061A
Authority
GT
Guatemala
Prior art keywords
compounds
picornaviral
novelty
proteases
protease inhibitors
Prior art date
Application number
GT199700061A
Other languages
English (en)
Inventor
Steven Weber
Peter S Dragovich
Thomas J Prins
Siegfried Reich
Thomas L Little Jr
Ethel S Littlefield
Joseph T Marakovits
Ted M Bleckman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27360847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT199700061(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/850,398 external-priority patent/US5856530A/en
Application filed filed Critical
Publication of GT199700061A publication Critical patent/GT199700061A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Abstract

LOS INHIBIDORES DE PROTEASAS DE 3C PICORNAVIRALES, OBTENIBLES POR SINTESIS QUIMICA, INHIBEN O BLOQUEAN LA ACTIVIDAD BIOLOGICA DE LAS PROTEASAS DE 3C PICORNAVIRALES. ESTOS COMPUESTOS, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS, SON APTOS PARA TRATAR A PACIENTES O HUESPEDES INFECTADOS CON UN PICORNAVIRUS O MAS. SE PUEDE UTILIZAR VARIOS METODOS E INTERMEDIOS NOVEDOSOS PARA PREPARAR LOS INHIBIDORES DE PROTEASAS DE 3C PICORNAVIRALES NOVEDOSOS DE ESTA INVENCION. LOS INVENTORES DEMUESTRAN QUE LOS COMPUESTOS DE ESTA INVENCION SE ENLAZAN CON LAS PROTEASAS DE 3C RINOVIRUS Y PREFERENTEMENTE TIENEN ACTIVIDAD DE CULTIVO CELULAR ANTIVIRAL. LA INVENCION APUNTA A UN PROTOTIPO DE ESTRUCTURA QUIMICA (V. FORMULA I), DONDE: R1...{H,F, R, OH, SH, OR, SR; R2 & R5...{UN GRUPO DE COMPUESTOS LISTADOS; Z...{H,F, R, CICLOR, HETEROCICLO, AR, C(O)R, CON(R), NO2, SO(R); DEBERA REVISARSE EL EXPEDIENTE ORIGINAL PARA EJEMPLIFICAR COMPUESTOS ESPECIFICOS.
GT199700061A 1996-05-14 1997-05-13 Procedimiento para la obtencion de "compuestos antipicornavirales y metodos para su uso y preparacion". GT199700061A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1766696P 1996-05-14 1996-05-14
US64568796A 1996-05-14 1996-05-14
US08/850,398 US5856530A (en) 1996-05-14 1997-05-02 Antipicornaviral compounds and methods for their use and preparation

Publications (1)

Publication Number Publication Date
GT199700061A true GT199700061A (es) 1998-11-04

Family

ID=27360847

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199700061A GT199700061A (es) 1996-05-14 1997-05-13 Procedimiento para la obtencion de "compuestos antipicornavirales y metodos para su uso y preparacion".

Country Status (12)

Country Link
EP (1) EP0910572B1 (es)
JP (1) JP2000506903A (es)
AR (1) AR007128A1 (es)
AT (1) ATE294187T1 (es)
AU (1) AU722704B2 (es)
CA (1) CA2254343A1 (es)
CO (1) CO4950551A1 (es)
DE (1) DE69733137T2 (es)
ES (1) ES2242225T3 (es)
GT (1) GT199700061A (es)
PA (1) PA8429901A1 (es)
WO (1) WO1997043305A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214799B1 (en) 1996-05-14 2001-04-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
YU66000A (sh) * 1998-04-30 2003-12-31 Agouron Pharmaceuticals Inc. Antipikovirusna jedinjenja, njihovo dobijanje i upotreba
EP1329457B1 (en) * 1998-04-30 2005-11-02 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds, their preparation and use
CA2380647A1 (en) 1999-08-04 2001-02-15 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
PE20010517A1 (es) * 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
US6774243B2 (en) 1999-08-24 2004-08-10 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US6355807B1 (en) 1999-08-24 2002-03-12 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20020157A1 (es) * 1999-12-03 2002-02-22 Agouron Pharma Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis
PA8515201A1 (es) 2000-04-14 2002-10-24 Agouron Pharma Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
EP1283199A4 (en) * 2000-05-16 2003-12-17 Takeda Chemical Industries Ltd MELANIN CONCENTRATION HORMONE ANTAGONIST
BR0111727A (pt) * 2000-06-14 2003-05-27 Agouron Pharma Compostos e composições antipicornavirais, seus usos farmacêuticos, e materiais para a sua sìntese
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
CA2479764C (en) 2002-03-22 2013-07-30 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
CN1922137A (zh) 2003-12-31 2007-02-28 太景生物科技股份有限公司 蛋白酶抑制剂
CN102105485B (zh) 2008-05-21 2016-01-13 新世界实验室公司 选择性胱天蛋白酶抑制剂及其用途
AU2009333391B2 (en) * 2008-12-15 2013-05-02 Taigen Biotechnology Co., Ltd. Stereoselective synthesis of piperidine derivatives
US9045524B2 (en) 2009-05-21 2015-06-02 Novagenesis Foundation Selective caspase inhibitors and uses thereof
ES2665301T3 (es) 2011-04-15 2018-04-25 Genesis Technologies Limited Inhibidores selectivos de cisteína proreasa y usos de los mismos
CA2850003C (en) 2011-09-27 2020-01-07 Kansas State University Research Foundation Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
US9309284B2 (en) 2012-05-02 2016-04-12 Kansas State University Reasearch Foundation Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
US20230151034A1 (en) * 2020-03-17 2023-05-18 Cocrystal Pharma, Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
WO2022156692A1 (zh) * 2021-01-22 2022-07-28 中国人民解放军军事科学院军事医学研究院 一种环肽类病毒蛋白酶抑制剂，其制备方法，及其在抗病毒药物中的应用

Also Published As

Publication number Publication date
PA8429901A1 (es) 2000-09-29
CO4950551A1 (es) 2000-09-01
EP0910572B1 (en) 2005-04-27
AU722704B2 (en) 2000-08-10
EP0910572A1 (en) 1999-04-28
AU3005997A (en) 1997-12-05
DE69733137D1 (de) 2005-06-02
DE69733137T2 (de) 2006-03-02
AR007128A1 (es) 1999-10-13
WO1997043305A1 (en) 1997-11-20
ES2242225T3 (es) 2005-11-01
ATE294187T1 (de) 2005-05-15
CA2254343A1 (en) 1997-11-20
JP2000506903A (ja) 2000-06-06

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