CO4950551A1 - Compuestos antipicornavirales y inhibidores de proteasa 3c y composiciones frmaceuticas que los contienen . - Google Patents
Compuestos antipicornavirales y inhibidores de proteasa 3c y composiciones frmaceuticas que los contienen .Info
- Publication number
- CO4950551A1 CO4950551A1 CO97025840A CO97025840A CO4950551A1 CO 4950551 A1 CO4950551 A1 CO 4950551A1 CO 97025840 A CO97025840 A CO 97025840A CO 97025840 A CO97025840 A CO 97025840A CO 4950551 A1 CO4950551 A1 CO 4950551A1
- Authority
- CO
- Colombia
- Prior art keywords
- protease
- inhibitors
- pharmaceutical compositions
- compositions containing
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un compuesto de la fórmula (I):dondeR1 es H, F, un grupo alquilo, OH, SH, un grupo O-alquilo o un grupo S-alquilo; R2 y R5 se seleccionan independientemente de H,un grupo alquilo, donde dicho grupo alquilo es distinto acon la salvedad de que por lo menos uno de R2 o R5 debe ser y donde, cuando R2 o R5 esX es = CH o = CF e Y1 es = CH o =CFo X e Y1 junto con Q´ forman un anillo de tres miembrosen el cual Q´ es -C(R10 )(R11 )- u -O-, X es -CH- o CF-e Y1 es -CH-, -CF-, o -C(alquilo)-, donde R10 y R11 son independientemente H, un halógeno o ...
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1766696P | 1996-05-14 | 1996-05-14 | |
US64568796A | 1996-05-14 | 1996-05-14 | |
US08/850,398 US5856530A (en) | 1996-05-14 | 1997-05-02 | Antipicornaviral compounds and methods for their use and preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4950551A1 true CO4950551A1 (es) | 2000-09-01 |
Family
ID=27360847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97025840A CO4950551A1 (es) | 1996-05-14 | 1997-05-14 | Compuestos antipicornavirales y inhibidores de proteasa 3c y composiciones frmaceuticas que los contienen . |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0910572B1 (es) |
JP (1) | JP2000506903A (es) |
AR (1) | AR007128A1 (es) |
AT (1) | ATE294187T1 (es) |
AU (1) | AU722704B2 (es) |
CA (1) | CA2254343A1 (es) |
CO (1) | CO4950551A1 (es) |
DE (1) | DE69733137T2 (es) |
ES (1) | ES2242225T3 (es) |
GT (1) | GT199700061A (es) |
PA (1) | PA8429901A1 (es) |
WO (1) | WO1997043305A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214799B1 (en) | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
US5962487A (en) * | 1997-12-16 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
EP1329457B1 (en) * | 1998-04-30 | 2005-11-02 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, their preparation and use |
AP2000001934A0 (en) * | 1998-04-30 | 2000-12-31 | Agouron Pharma | Antipicornaviral compounds, their preparation and use. |
ES2230135T3 (es) | 1999-08-04 | 2005-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis. |
US6774243B2 (en) | 1999-08-24 | 2004-08-10 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
PE20010517A1 (es) * | 1999-08-24 | 2001-05-16 | Agouron Pharma | Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves |
US6355807B1 (en) | 1999-08-24 | 2002-03-12 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
PA8507801A1 (es) * | 1999-12-03 | 2002-08-26 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
PA8515201A1 (es) | 2000-04-14 | 2002-10-24 | Agouron Pharma | Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis |
CA2408913A1 (en) * | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
HUP0301331A3 (en) | 2000-06-14 | 2004-03-01 | Agouron Pharmaceuticals Inc La | Antipicornaviral compounds process for their preparation and compositions containing them, their pharmaceutical uses, and intermediates for their synthesis |
US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
CN1633289A (zh) * | 2002-03-22 | 2005-06-29 | 卫材株式会社 | 半星芒体衍生物及其用途 |
AU2004312547A1 (en) | 2003-12-31 | 2005-07-21 | Taigen Biotechnology | Protease inhibitors |
US7462594B2 (en) | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
AU2009250295B2 (en) | 2008-05-21 | 2014-05-01 | Genesis Technologies Limited | Selective caspase inhibitors and uses thereof |
CA2743700C (en) * | 2008-12-15 | 2016-07-12 | Taigen Biotechnology Co., Ltd. | Stereoselective synthesis of piperidine derivatives |
US9045524B2 (en) | 2009-05-21 | 2015-06-02 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
CA2833082C (en) | 2011-04-15 | 2019-12-31 | New World Laboratories, Inc. | Selective cysteine protease inhibitors and uses thereof |
US9474759B2 (en) | 2011-09-27 | 2016-10-25 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
EP2844249A4 (en) | 2012-05-02 | 2016-03-09 | Univ Kansas State | MACROCYCLIC AND PEPTIDOMIMETIC COMPOUNDS AS VIRUZIDES AGAINST 3C OR 3C LIKE PROTEASES OF PICORNIVERS, CALICIVIRES AND CORONA VIRUSES |
WO2021188620A1 (en) * | 2020-03-17 | 2021-09-23 | Cocrystal Pharma Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
CN116648240A (zh) * | 2021-01-22 | 2023-08-25 | 中国人民解放军军事科学院军事医学研究院 | 一种环肽类病毒蛋白酶抑制剂,其制备方法,及其在抗病毒药物中的应用 |
-
1997
- 1997-05-13 CA CA002254343A patent/CA2254343A1/en not_active Abandoned
- 1997-05-13 AU AU30059/97A patent/AU722704B2/en not_active Ceased
- 1997-05-13 ES ES97924707T patent/ES2242225T3/es not_active Expired - Lifetime
- 1997-05-13 DE DE69733137T patent/DE69733137T2/de not_active Expired - Fee Related
- 1997-05-13 AT AT97924707T patent/ATE294187T1/de not_active IP Right Cessation
- 1997-05-13 WO PCT/US1997/008112 patent/WO1997043305A1/en active IP Right Grant
- 1997-05-13 EP EP97924707A patent/EP0910572B1/en not_active Expired - Lifetime
- 1997-05-13 JP JP9541076A patent/JP2000506903A/ja not_active Withdrawn
- 1997-05-13 GT GT199700061A patent/GT199700061A/es unknown
- 1997-05-14 PA PA19978429901A patent/PA8429901A1/es unknown
- 1997-05-14 CO CO97025840A patent/CO4950551A1/es unknown
- 1997-05-14 AR ARP970102012A patent/AR007128A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0910572B1 (en) | 2005-04-27 |
CA2254343A1 (en) | 1997-11-20 |
DE69733137D1 (de) | 2005-06-02 |
WO1997043305A1 (en) | 1997-11-20 |
DE69733137T2 (de) | 2006-03-02 |
ATE294187T1 (de) | 2005-05-15 |
ES2242225T3 (es) | 2005-11-01 |
EP0910572A1 (en) | 1999-04-28 |
AU722704B2 (en) | 2000-08-10 |
AR007128A1 (es) | 1999-10-13 |
JP2000506903A (ja) | 2000-06-06 |
AU3005997A (en) | 1997-12-05 |
GT199700061A (es) | 1998-11-04 |
PA8429901A1 (es) | 2000-09-29 |
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