AR007128A1 - Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto - Google Patents
Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuestoInfo
- Publication number
- AR007128A1 AR007128A1 ARP970102012A ARP970102012A AR007128A1 AR 007128 A1 AR007128 A1 AR 007128A1 AR P970102012 A ARP970102012 A AR P970102012A AR P970102012 A ARP970102012 A AR P970102012A AR 007128 A1 AR007128 A1 AR 007128A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- compound
- alkyl group
- alkyl
- antipicornaviral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
Abstract
Tiene por objeto un compuesto antipicornaviral. Los inhibidores de proteasas de 3C picornavirales, obtenibles por síntesis química, inhiben obloquean la actividad biológica de las proteasas de 3C picornavirales. Estos compuestos, asícomo las composiciones farmacéuticas que contienen estoscompuestos, y que también forman parte, son aptos para tratar a pacientes o huéspedes infectados con un picornavirus o más. Asimismo forman parte métodospara preparar los inhibidores deproteasa s de 3C picornavirales. Un compuesto antipicornaviral, que responde a la fórmula (I), donde R1 es H, F, un grupoalquilo, OH, SH, un grupo O-alquilo o un grupo S-alquilo; R2 y R5 se seleccionan independientemente de H (fórmulas(II)), o u n grupo alquilo, dondedicho grupo alquilo es distinto a fórmulas (III) con la salvedad de que por lo menos uno de R2 o R5, debe ser según fórmulas (IV) y donde, cuando R2 o R5es fórmula (V); X es =CH o =CF e Y1 es =CH o =CF o X e Y1junto con Q f orman un anillo de tres miembros en el cual Q es -C(R10)(R11)- u -O-, X es -CH- o-CF- e Y1 es -CH-, -CF-, o -C(alquilo)-, donde R10 y R11 son independientemente H, un halógeno o un grupo alquilo o, junto con el átomo de carbono alcualestán unidos, forman un grupo cicloalquilo o un grupo heterocicloalquilo, o X es -CH2-, -CF3-, -CHF- o -S- e Y1 es -O-, -S-, -NR12-, -C(R13)(R14)-, -C(O)-,-C(S)- o -C(CR13R14)- donde R12 es H o alquilo y R13 y R14 sonindependientemente H, F o un grupo alquilo o, junto con el átomo con el cualestán enlazados, forman un grupo cicloalquilo o un grupo heterocicloalquilo; y A1 es C, CH, CF, S, P, Se, N, NR15, S(O), Se(O), P-OR15 o P-NR15R16, dondeR15 y R16 sonindependientemente un grupo al quilo, un grupo cicloalquilo, un grupo heterocicloalquilo, un grupo arilo o un grupo heteroarilo o, junto con el
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1766696P | 1996-05-14 | 1996-05-14 | |
US64568796A | 1996-05-14 | 1996-05-14 | |
US08/850,398 US5856530A (en) | 1996-05-14 | 1997-05-02 | Antipicornaviral compounds and methods for their use and preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
AR007128A1 true AR007128A1 (es) | 1999-10-13 |
Family
ID=27360847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970102012A AR007128A1 (es) | 1996-05-14 | 1997-05-14 | Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0910572B1 (es) |
JP (1) | JP2000506903A (es) |
AR (1) | AR007128A1 (es) |
AT (1) | ATE294187T1 (es) |
AU (1) | AU722704B2 (es) |
CA (1) | CA2254343A1 (es) |
CO (1) | CO4950551A1 (es) |
DE (1) | DE69733137T2 (es) |
ES (1) | ES2242225T3 (es) |
GT (1) | GT199700061A (es) |
PA (1) | PA8429901A1 (es) |
WO (1) | WO1997043305A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214799B1 (en) | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
US5962487A (en) * | 1997-12-16 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
EP1329457B1 (en) * | 1998-04-30 | 2005-11-02 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, their preparation and use |
ES2205760T3 (es) | 1998-04-30 | 2004-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos antipicornavirales, su preparacion y su utilizacion. |
MXPA02001179A (es) | 1999-08-04 | 2002-07-30 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis. |
PE20010517A1 (es) * | 1999-08-24 | 2001-05-16 | Agouron Pharma | Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves |
US6355807B1 (en) | 1999-08-24 | 2002-03-12 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
US6774243B2 (en) | 1999-08-24 | 2004-08-10 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
PE20020157A1 (es) | 1999-12-03 | 2002-02-22 | Agouron Pharma | Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis |
PA8515201A1 (es) * | 2000-04-14 | 2002-10-24 | Agouron Pharma | Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis |
AU2001256733A1 (en) * | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
BR0111727A (pt) * | 2000-06-14 | 2003-05-27 | Agouron Pharma | Compostos e composições antipicornavirais, seus usos farmacêuticos, e materiais para a sua sìntese |
NZ555951A (en) | 2002-03-22 | 2009-01-31 | Eisai Co Ltd | Hemiasterlin derivatives and uses thereof |
US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
US7462594B2 (en) | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
CA2550515A1 (en) * | 2003-12-31 | 2005-07-21 | Taigen Biotechnology | Protease inhibitors |
DK2288615T3 (en) | 2008-05-21 | 2017-09-04 | Genesis Tech Ltd | SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF |
WO2010077798A2 (en) * | 2008-12-15 | 2010-07-08 | Taigen Biotechnology Co., Ltd. | Stereoselective synthesis of piperidine derivatives |
US9045524B2 (en) | 2009-05-21 | 2015-06-02 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
US9944674B2 (en) | 2011-04-15 | 2018-04-17 | Genesis Technologies Limited | Selective cysteine protease inhibitors and uses thereof |
EP2760827A4 (en) | 2011-09-27 | 2015-06-24 | Univ Kansas State | ANTIVIRAL MEDIUM WITH A WIDE SPECTRUM AGAINST 3C OR 3C-SIMILAR PROTEASES FROM PICORNIVIRUS SUPERCLUSTS: PICORNIVERS, CALICIVIRES AND CORONA VIRUSES |
EP2844249A4 (en) | 2012-05-02 | 2016-03-09 | Univ Kansas State | MACROCYCLIC AND PEPTIDOMIMETIC COMPOUNDS AS VIRUZIDES AGAINST 3C OR 3C LIKE PROTEASES OF PICORNIVERS, CALICIVIRES AND CORONA VIRUSES |
US20230151034A1 (en) * | 2020-03-17 | 2023-05-18 | Cocrystal Pharma, Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
CN116648240A (zh) * | 2021-01-22 | 2023-08-25 | 中国人民解放军军事科学院军事医学研究院 | 一种环肽类病毒蛋白酶抑制剂,其制备方法,及其在抗病毒药物中的应用 |
-
1997
- 1997-05-13 WO PCT/US1997/008112 patent/WO1997043305A1/en active IP Right Grant
- 1997-05-13 AT AT97924707T patent/ATE294187T1/de not_active IP Right Cessation
- 1997-05-13 AU AU30059/97A patent/AU722704B2/en not_active Ceased
- 1997-05-13 JP JP9541076A patent/JP2000506903A/ja not_active Withdrawn
- 1997-05-13 ES ES97924707T patent/ES2242225T3/es not_active Expired - Lifetime
- 1997-05-13 EP EP97924707A patent/EP0910572B1/en not_active Expired - Lifetime
- 1997-05-13 GT GT199700061A patent/GT199700061A/es unknown
- 1997-05-13 CA CA002254343A patent/CA2254343A1/en not_active Abandoned
- 1997-05-13 DE DE69733137T patent/DE69733137T2/de not_active Expired - Fee Related
- 1997-05-14 CO CO97025840A patent/CO4950551A1/es unknown
- 1997-05-14 AR ARP970102012A patent/AR007128A1/es not_active Application Discontinuation
- 1997-05-14 PA PA19978429901A patent/PA8429901A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP0910572A1 (en) | 1999-04-28 |
JP2000506903A (ja) | 2000-06-06 |
WO1997043305A1 (en) | 1997-11-20 |
ATE294187T1 (de) | 2005-05-15 |
GT199700061A (es) | 1998-11-04 |
EP0910572B1 (en) | 2005-04-27 |
AU722704B2 (en) | 2000-08-10 |
CA2254343A1 (en) | 1997-11-20 |
PA8429901A1 (es) | 2000-09-29 |
AU3005997A (en) | 1997-12-05 |
ES2242225T3 (es) | 2005-11-01 |
DE69733137D1 (de) | 2005-06-02 |
CO4950551A1 (es) | 2000-09-01 |
DE69733137T2 (de) | 2006-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |