ATE294187T1 - Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung - Google Patents

Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung

Info

Publication number
ATE294187T1
ATE294187T1 AT97924707T AT97924707T ATE294187T1 AT E294187 T1 ATE294187 T1 AT E294187T1 AT 97924707 T AT97924707 T AT 97924707T AT 97924707 T AT97924707 T AT 97924707T AT E294187 T1 ATE294187 T1 AT E294187T1
Authority
AT
Austria
Prior art keywords
picornavirus
preparation
protease inhibitors
protease
inhibitors
Prior art date
Application number
AT97924707T
Other languages
English (en)
Inventor
Stephen E Webber
Peter S Dragovich
Thomas J Prins
Siegfried H Reich
Thomas L Little Jr
Ethel S Littlefield
Joseph T Marakovits
Robert E Babine
Ted M Bleckman
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27360847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE294187(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/850,398 external-priority patent/US5856530A/en
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of ATE294187T1 publication Critical patent/ATE294187T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
AT97924707T 1996-05-14 1997-05-13 Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung ATE294187T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64568796A 1996-05-14 1996-05-14
US1766696P 1996-05-14 1996-05-14
US08/850,398 US5856530A (en) 1996-05-14 1997-05-02 Antipicornaviral compounds and methods for their use and preparation
PCT/US1997/008112 WO1997043305A1 (en) 1996-05-14 1997-05-13 Inhibitors of picornavirus 3c proteases and methods for their use and preparation

Publications (1)

Publication Number Publication Date
ATE294187T1 true ATE294187T1 (de) 2005-05-15

Family

ID=27360847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97924707T ATE294187T1 (de) 1996-05-14 1997-05-13 Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung

Country Status (12)

Country Link
EP (1) EP0910572B1 (de)
JP (1) JP2000506903A (de)
AR (1) AR007128A1 (de)
AT (1) ATE294187T1 (de)
AU (1) AU722704B2 (de)
CA (1) CA2254343A1 (de)
CO (1) CO4950551A1 (de)
DE (1) DE69733137T2 (de)
ES (1) ES2242225T3 (de)
GT (1) GT199700061A (de)
PA (1) PA8429901A1 (de)
WO (1) WO1997043305A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214799B1 (en) 1996-05-14 2001-04-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
EP1329457B1 (de) * 1998-04-30 2005-11-02 Agouron Pharmaceuticals, Inc. Antipicornavirale Verbindungen, deren Herstellung und Verwendung
EA003856B1 (ru) 1998-04-30 2003-10-30 Агурон Фармасьютикалз, Инк. Антипикорнавирусные композиции, их получение и применение
ES2230135T3 (es) 1999-08-04 2005-05-01 Agouron Pharmaceuticals, Inc. Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis.
US6774243B2 (en) 1999-08-24 2004-08-10 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20010517A1 (es) * 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
US6355807B1 (en) 1999-08-24 2002-03-12 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20020157A1 (es) 1999-12-03 2002-02-22 Agouron Pharma Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis
PA8515201A1 (es) 2000-04-14 2002-10-24 Agouron Pharma Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
MXPA02012456A (es) * 2000-06-14 2004-01-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis.
EP2374454B1 (de) 2002-03-22 2016-05-11 Eisai R&D Management Co., Ltd. Hemiasterlin-derivate und deren verwendung in der behandlung von krebs
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
WO2005066123A1 (en) * 2003-12-31 2005-07-21 Taigen Biotechnology Protease inhibitors
EP2288615B1 (de) 2008-05-21 2017-06-21 Genesis Technologies Limited Selektive caspasehemmer und ihre verwendung
WO2010077798A2 (en) * 2008-12-15 2010-07-08 Taigen Biotechnology Co., Ltd. Stereoselective synthesis of piperidine derivatives
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
CA2833082C (en) * 2011-04-15 2019-12-31 New World Laboratories, Inc. Selective cysteine protease inhibitors and uses thereof
CA2850003C (en) 2011-09-27 2020-01-07 Kansas State University Research Foundation Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
EP2844249A4 (de) 2012-05-02 2016-03-09 Univ Kansas State Makrocyclische und peptidomimetische verbindungen als viruzide gegen 3c- oder 3c-like-proteasen von picornaviren, caliciviren und coronaviren
US20230151034A1 (en) * 2020-03-17 2023-05-18 Cocrystal Pharma, Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
CN116648240A (zh) * 2021-01-22 2023-08-25 中国人民解放军军事科学院军事医学研究院 一种环肽类病毒蛋白酶抑制剂，其制备方法，及其在抗病毒药物中的应用

Also Published As

Publication number Publication date
CA2254343A1 (en) 1997-11-20
AU722704B2 (en) 2000-08-10
JP2000506903A (ja) 2000-06-06
WO1997043305A1 (en) 1997-11-20
AU3005997A (en) 1997-12-05
DE69733137T2 (de) 2006-03-02
PA8429901A1 (es) 2000-09-29
ES2242225T3 (es) 2005-11-01
CO4950551A1 (es) 2000-09-01
EP0910572A1 (de) 1999-04-28
EP0910572B1 (de) 2005-04-27
GT199700061A (es) 1998-11-04
DE69733137D1 (de) 2005-06-02
AR007128A1 (es) 1999-10-13

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