ATE294187T1 - Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung - Google Patents

Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung

Info

Publication number
ATE294187T1
ATE294187T1 AT97924707T AT97924707T ATE294187T1 AT E294187 T1 ATE294187 T1 AT E294187T1 AT 97924707 T AT97924707 T AT 97924707T AT 97924707 T AT97924707 T AT 97924707T AT E294187 T1 ATE294187 T1 AT E294187T1
Authority
AT
Austria
Prior art keywords
picornavirus
preparation
protease inhibitors
protease
inhibitors
Prior art date
Application number
AT97924707T
Other languages
English (en)
Inventor
Stephen E Webber
Peter S Dragovich
Thomas J Prins
Siegfried H Reich
Thomas L Little Jr
Ethel S Littlefield
Joseph T Marakovits
Robert E Babine
Ted M Bleckman
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27360847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE294187(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/850,398 external-priority patent/US5856530A/en
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of ATE294187T1 publication Critical patent/ATE294187T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
AT97924707T 1996-05-14 1997-05-13 Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung ATE294187T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64568796A 1996-05-14 1996-05-14
US1766696P 1996-05-14 1996-05-14
US08/850,398 US5856530A (en) 1996-05-14 1997-05-02 Antipicornaviral compounds and methods for their use and preparation
PCT/US1997/008112 WO1997043305A1 (en) 1996-05-14 1997-05-13 Inhibitors of picornavirus 3c proteases and methods for their use and preparation

Publications (1)

Publication Number Publication Date
ATE294187T1 true ATE294187T1 (de) 2005-05-15

Family

ID=27360847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97924707T ATE294187T1 (de) 1996-05-14 1997-05-13 Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung

Country Status (12)

Country Link
EP (1) EP0910572B1 (de)
JP (1) JP2000506903A (de)
AR (1) AR007128A1 (de)
AT (1) ATE294187T1 (de)
AU (1) AU722704B2 (de)
CA (1) CA2254343A1 (de)
CO (1) CO4950551A1 (de)
DE (1) DE69733137T2 (de)
ES (1) ES2242225T3 (de)
GT (1) GT199700061A (de)
PA (1) PA8429901A1 (de)
WO (1) WO1997043305A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214799B1 (en) 1996-05-14 2001-04-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
EP1329457B1 (de) * 1998-04-30 2005-11-02 Agouron Pharmaceuticals, Inc. Antipicornavirale Verbindungen, deren Herstellung und Verwendung
KR20010043004A (ko) 1998-04-30 2001-05-25 개리 이. 프라이드만 피코르나 바이러스 억제 화합물, 그의 제조 방법 및 용도
CN1372566A (zh) 1999-08-04 2002-10-02 阿格罗尼制药公司 抗细小核糖核酸病毒的化合物和组合物,它们的药物用途,及其合成原料
US6355807B1 (en) 1999-08-24 2002-03-12 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20010517A1 (es) * 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
US6774243B2 (en) 1999-08-24 2004-08-10 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PA8507801A1 (es) 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
BR0111727A (pt) 2000-06-14 2003-05-27 Agouron Pharma Compostos e composições antipicornavirais, seus usos farmacêuticos, e materiais para a sua sìntese
EP1490054A2 (de) * 2002-03-22 2004-12-29 Eisai Co., Ltd Hemiasterlin-derivate und deren verwendung in der behandlung von krebs
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
CN1922137A (zh) * 2003-12-31 2007-02-28 太景生物科技股份有限公司 蛋白酶抑制剂
WO2009140765A1 (en) 2008-05-21 2009-11-26 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
WO2010077798A2 (en) * 2008-12-15 2010-07-08 Taigen Biotechnology Co., Ltd. Stereoselective synthesis of piperidine derivatives
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
WO2012140500A1 (en) * 2011-04-15 2012-10-18 New World Laboratories, Inc. Selective cysteine protease inhibitors and uses thereof
US9474759B2 (en) 2011-09-27 2016-10-25 Kansas State University Research Foundation Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
EP2844249A4 (de) 2012-05-02 2016-03-09 Univ Kansas State Makrocyclische und peptidomimetische verbindungen als viruzide gegen 3c- oder 3c-like-proteasen von picornaviren, caliciviren und coronaviren
WO2021188620A1 (en) * 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
WO2022156692A1 (zh) * 2021-01-22 2022-07-28 中国人民解放军军事科学院军事医学研究院 一种环肽类病毒蛋白酶抑制剂，其制备方法，及其在抗病毒药物中的应用

Also Published As

Publication number Publication date
DE69733137D1 (de) 2005-06-02
PA8429901A1 (es) 2000-09-29
WO1997043305A1 (en) 1997-11-20
CA2254343A1 (en) 1997-11-20
EP0910572A1 (de) 1999-04-28
AR007128A1 (es) 1999-10-13
JP2000506903A (ja) 2000-06-06
CO4950551A1 (es) 2000-09-01
DE69733137T2 (de) 2006-03-02
GT199700061A (es) 1998-11-04
EP0910572B1 (de) 2005-04-27
ES2242225T3 (es) 2005-11-01
AU3005997A (en) 1997-12-05
AU722704B2 (en) 2000-08-10

Similar Documents

Publication Publication Date Title
ATE294187T1 (de) Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung
ATE197122T1 (de) Hämorrhoidenzusammensetzungen und verfahren zur verwendung
DE69725169D1 (de) Zusammensetzungen und verfahren zur anregung des wachstums von neuriten
DE69635445D1 (de) Alkalialuminiumhydroxycarbonatzusammensetzung und verfahren zur herstellung
DE69434340D1 (de) Überziehbare Zusammensetzung und Verfahren zur Herstellung von Schleifmitteln
DE69821670T2 (de) Herstellung eines Additivs und Verfahren zur Verwendung
DE69418851D1 (de) Verfahren zur Herstellung von Befestigungsvorrichtungen
DE69739763D1 (de) Halbleiteranordnung und Verfahren zur Herstellung
DE69739555D1 (de) Umgossene verglassung und verfahren zur herstellung
ID17102A (id) Bahan berserat penghilang bau dan metoda pembuatannya
DE69814117D1 (de) Klebender Gegenstand, Klebstoff, Isolierkit und Verfahren zur Herstellung eines klebenden Gegenstandes
DE59702349D1 (de) Verfahren zur herstellung von aminen und aminonitrilen
DE69736286D1 (de) Verfahren zur herstellung und transformation von manioka protoplasten
DE69832282D1 (de) Polysilazan-amine und verfahren zur herstellung
DE60038663D1 (de) Thyristoren und verfahren zur herstellung
DE69637746D1 (de) Transistor und verfahren zur herstellung
DE69834578D1 (de) Verfahren zur behandlung von zementaufschlämmungen
DE59703443D1 (de) Verfahren zur herstellung von aminen und aminonitrilen
DE69730268D1 (de) Verfahren und System zur Bestimmung von Farbmittelmengen
ATE204382T1 (de) Verfahren und gerät zur bestimmung der qualität von kulturpflanzen
DE69732520D1 (de) Ladungsgekoppelte anordnung und verfahren zur herstellung
DE69434736D1 (de) Isolationsstruktur und Verfahren zur Herstellung
DE69713040D1 (de) Verfahren zur Herstellung von Cyclopropylacetylen und dessen Derivaten
DE69936465D1 (de) Cellolosetriacetate und verfahren zur herstellung
DE69835975D1 (de) Implantat und Verfahren zur Herstellung eines Implantats

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties