DE60207198D1 - Transplantate für die wiederherstellung von osteochondralen schäden - Google Patents

Transplantate für die wiederherstellung von osteochondralen schäden

Info

Publication number
DE60207198D1
DE60207198D1 DE60207198T DE60207198T DE60207198D1 DE 60207198 D1 DE60207198 D1 DE 60207198D1 DE 60207198 T DE60207198 T DE 60207198T DE 60207198 T DE60207198 T DE 60207198T DE 60207198 D1 DE60207198 D1 DE 60207198D1
Authority
DE
Germany
Prior art keywords
osteochondral
transplants
reconstruction
damages
dimensional matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60207198T
Other languages
English (en)
Other versions
DE60207198T2 (de
Inventor
Alessandra Pavesio
Lanfranco Callegaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anika Therapeutics SRL
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Publication of DE60207198D1 publication Critical patent/DE60207198D1/de
Application granted granted Critical
Publication of DE60207198T2 publication Critical patent/DE60207198T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
DE60207198T 2001-02-09 2002-02-06 Transplantate für die wiederherstellung von osteochondralen schäden Expired - Lifetime DE60207198T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITPD20010032 2001-02-09
IT2001PD000032A ITPD20010032A1 (it) 2001-02-09 2001-02-09 Innesti ingegnerizzati per la riparazione di difetti osteocondrali
PCT/EP2002/001224 WO2002070030A1 (en) 2001-02-09 2002-02-06 Grafts for the repair of osteochondral defects

Publications (2)

Publication Number Publication Date
DE60207198D1 true DE60207198D1 (de) 2005-12-15
DE60207198T2 DE60207198T2 (de) 2006-06-01

Family

ID=11452207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60207198T Expired - Lifetime DE60207198T2 (de) 2001-02-09 2002-02-06 Transplantate für die wiederherstellung von osteochondralen schäden

Country Status (11)

Country Link
US (1) US7968111B2 (de)
EP (1) EP1357953B1 (de)
JP (1) JP2004524904A (de)
AT (1) ATE309007T1 (de)
AU (1) AU2002256617B8 (de)
CA (1) CA2437440C (de)
DE (1) DE60207198T2 (de)
DK (1) DK1357953T3 (de)
ES (1) ES2250642T3 (de)
IT (1) ITPD20010032A1 (de)
WO (1) WO2002070030A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10260958A1 (de) * 2002-12-20 2004-07-08 Sustech Gmbh & Co. Kg Kompositmaterialien aus Calciumverbindungen und Glucuronsäure- und/oder Iduronsäurehaltigen Polysacchariden
EP1613364B1 (de) 2003-02-26 2013-01-16 Zimmer Orthobiologics, Inc. Präparat zur reparatur von knorpelgewebe, insbesondere von gelenkknorpel-defekten
US20050074877A1 (en) * 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
ITPD20030286A1 (it) * 2003-11-27 2005-05-28 Fidia Advanced Biopolymers Srl Strutture composite multistrato contenenti acido ialuronico
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
ITPD20040053A1 (it) 2004-02-27 2004-05-27 Fidia Advanced Biopolymers Srl Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
US8313524B2 (en) 2004-08-31 2012-11-20 C. R. Bard, Inc. Self-sealing PTFE graft with kink resistance
CA2611119A1 (en) * 2005-06-08 2006-12-14 C.R. Bard Inc. Grafts and stents having inorganic bio-compatible calcium salt
JP2009501027A (ja) 2005-06-17 2009-01-15 シー・アール・バード・インコーポレイテツド 締付後のよじれ耐性を有する血管移植片
DE102005030614B4 (de) * 2005-06-30 2014-05-08 Biotissue Ag Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel
WO2007007062A2 (en) * 2005-07-08 2007-01-18 Depuy International Limited Cartilage repair implant
EP1764117A1 (de) 2005-09-20 2007-03-21 Zimmer GmbH Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung
US8636794B2 (en) 2005-11-09 2014-01-28 C. R. Bard, Inc. Grafts and stent grafts having a radiopaque marker
CN100398496C (zh) * 2005-12-29 2008-07-02 武汉理工大学 层状多孔磷酸钙生物陶瓷的制备方法及其应用
JP5173199B2 (ja) * 2006-01-16 2013-03-27 株式会社アイ・ティー・オー 創傷治癒用高分子組成物
JP5538493B2 (ja) * 2006-01-16 2014-07-02 株式会社アイ・ティー・オー 生体内組織用創傷治癒用フィルム及び生体内接着用フィルム
DE102006047346A1 (de) * 2006-10-06 2008-04-10 Transtissue Technologies Gmbh Matrix-Gel-Transplantat ohne Zellen
US9198749B2 (en) 2006-10-12 2015-12-01 C. R. Bard, Inc. Vascular grafts with multiple channels and methods for making
WO2008049281A1 (fr) * 2006-10-27 2008-05-02 Beijing Institute Of Transfusion Medicine Procédé de construction d'une construction de génie tissulaire hépatique et construction de génie tissulaire hépatique
AU2013203054B2 (en) * 2007-08-06 2017-05-18 Mesoblast, Inc. Methods of generating, repairing and/or maintaining connective tissue in vivo
WO2009155656A1 (en) 2008-06-25 2009-12-30 Angioblast Systems, Inc. Repair and/or reconstitution of invertebral discs
ES2923016T3 (es) * 2007-08-06 2022-09-22 Mesoblast Inc Células precursoras mesenquimales TNAP+ para el tratamiento de enfermedades del tejido conectivo
US8524494B2 (en) * 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US8535913B2 (en) * 2008-01-30 2013-09-17 Histogen, Inc. Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
US8257947B2 (en) * 2008-01-30 2012-09-04 Naughton Gail K Extracellular matrix compositions produced under hypoxic culture conditions
US8530415B2 (en) * 2008-01-30 2013-09-10 Histogen, Inc. Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
PT2451964T (pt) * 2009-07-10 2018-05-07 Histogen Inc Meio condiconado e composições de matriz extracelular de células cultivadas sob condições hipóxicas
WO2012051420A2 (en) 2010-10-13 2012-04-19 Cibor, Inc. Synthetic bone grafts constructed from carbon foam materials
US9119728B2 (en) 2011-01-17 2015-09-01 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
KR101306748B1 (ko) * 2012-03-29 2013-09-10 주식회사 바이오알파 성장인자 전달속도 조절이 가능한 히알루론산-인산칼슘 복합체 및 그 제조방법
WO2014041516A1 (en) 2012-09-14 2014-03-20 Ecole Polytechnique Federale De Lausanne (Epfl) Biocompatible multi-layered structure comprising foam layers and a functional interface
EP2945655B1 (de) 2013-01-15 2019-09-25 Tepha, Inc. Implantate zur regeneration von weichem und hartem gewebe
WO2018097198A1 (ja) * 2016-11-28 2018-05-31 株式会社バイオ未来工房 間葉系幹細胞の分離方法及びリン酸カルシウム類を含有する不織布の使用
CA3086956A1 (en) 2018-01-02 2019-07-11 Cartiheal (2009) Ltd. Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
CN112552035A (zh) * 2020-12-11 2021-03-26 湖北联结生物材料有限公司 一种可诱导生物活性3d打印陶瓷及其制备方法
CN115317672B (zh) * 2022-08-27 2023-11-14 四川大学 仿生骨软骨一体化修复植入体及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9101853D0 (sv) * 1991-06-17 1991-06-17 Jonas Wadstroem Improved tissue ashesive
IT1259090B (it) * 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1263316B (it) 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
US5939323A (en) * 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
DE19803673A1 (de) * 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrider Gelenkflächenersatz
US6872819B1 (en) 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
ITPD980169A1 (it) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1302534B1 (it) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6656489B1 (en) * 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.

Also Published As

Publication number Publication date
CA2437440A1 (en) 2002-09-12
EP1357953A1 (de) 2003-11-05
JP2004524904A (ja) 2004-08-19
EP1357953B1 (de) 2005-11-09
DE60207198T2 (de) 2006-06-01
AU2002256617B8 (en) 2007-02-15
US7968111B2 (en) 2011-06-28
WO2002070030A8 (en) 2002-12-05
ITPD20010032A1 (it) 2002-08-09
US20040076656A1 (en) 2004-04-22
ES2250642T3 (es) 2006-04-16
AU2002256617B2 (en) 2007-02-08
CA2437440C (en) 2012-04-03
WO2002070030A1 (en) 2002-09-12
ATE309007T1 (de) 2005-11-15
DK1357953T3 (da) 2006-01-16

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