SV2001000379A - Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis. - Google Patents
Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis.Info
- Publication number
- SV2001000379A SV2001000379A SV2001000379A SV2001000379A SV2001000379A SV 2001000379 A SV2001000379 A SV 2001000379A SV 2001000379 A SV2001000379 A SV 2001000379A SV 2001000379 A SV2001000379 A SV 2001000379A SV 2001000379 A SV2001000379 A SV 2001000379A
- Authority
- SV
- El Salvador
- Prior art keywords
- compounds
- synthesis
- compositions
- materials
- pharmaceutical uses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
COMPUESTOS DE FORMULA I, DONDE LAS VARIABLES DE LA FORMULA SON COMO SE DEFINE AQUI, QUE VENTAJOSAMENTE INHIBEN O BLOQUEAN LA ACTIVIDAD BIOLOGICA DE LA PROTEASA 3C PICORNAVIRAL. ESTOS COMPUESTOS, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS, SON UTILES PARA EL TRATAMIENTO DE PACIENTES O ANFITRIONES INFECTADOS CON UNO O MAS PICORNAVIRUSES, TAL COMO RVP. TAMBIEN SE DESCRIBEN METODOS INTERMEDIARIOS Y SINTETICOS PARA PREPARAR ESTOS COMPUESTOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19779600P | 2000-04-14 | 2000-04-14 | |
US19849700P | 2000-04-18 | 2000-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
SV2001000379A true SV2001000379A (es) | 2001-10-16 |
Family
ID=26893177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SV2001000379A SV2001000379A (es) | 2000-04-14 | 2001-04-17 | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis. |
Country Status (19)
Country | Link |
---|---|
US (3) | US6610730B2 (es) |
EP (1) | EP1274682A2 (es) |
JP (1) | JP2003531139A (es) |
KR (1) | KR20030019350A (es) |
CN (1) | CN1431995A (es) |
AR (1) | AR028338A1 (es) |
AU (1) | AU2001251639A1 (es) |
BR (1) | BR0110077A (es) |
CA (1) | CA2406475A1 (es) |
HU (1) | HUP0300928A3 (es) |
IL (1) | IL152243A0 (es) |
MX (1) | MXPA02010195A (es) |
PA (1) | PA8515201A1 (es) |
PE (1) | PE20011277A1 (es) |
PL (1) | PL365198A1 (es) |
SV (1) | SV2001000379A (es) |
UY (1) | UY26666A1 (es) |
WO (1) | WO2001079167A2 (es) |
ZA (1) | ZA200208257B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ535139A (en) | 2002-03-22 | 2007-07-27 | Eisai Co Ltd | Hemiasterlin derivatives and uses thereof in the treatment of cancer |
US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
US7462594B2 (en) * | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
AU2004312547A1 (en) * | 2003-12-31 | 2005-07-21 | Taigen Biotechnology | Protease inhibitors |
KR100891699B1 (ko) | 2007-04-10 | 2009-04-03 | 광주과학기술원 | 7-아미노-4-((s)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물 |
US8735324B2 (en) | 2008-01-25 | 2014-05-27 | Rhodia Operations | Esteramide solvents/coalescing agents in phytosanitary, cleaning, degreasing, stripping, lubricating, coating, and pigment/ink compositions |
WO2009148599A1 (en) * | 2008-06-04 | 2009-12-10 | Synta Pharmaceuticals Corp. | Pyrrole compunds that modulate hsp90 activity |
CA3183740A1 (en) * | 2020-06-10 | 2021-12-16 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
CN116648240A (zh) * | 2021-01-22 | 2023-08-25 | 中国人民解放军军事科学院军事医学研究院 | 一种环肽类病毒蛋白酶抑制剂,其制备方法,及其在抗病毒药物中的应用 |
US11851422B2 (en) | 2021-07-09 | 2023-12-26 | Aligos Therapeutics, Inc. | Anti-viral compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374623A (en) | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
IL112759A0 (en) | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
IT1269511B (it) | 1994-05-17 | 1997-04-01 | Univ Degli Studi Milano | Derivati di acidi ammino-solfonici , loro impiego nella sintesi di pseudopeptidi e procedimento per la loro preparazione |
US5523312A (en) * | 1994-09-27 | 1996-06-04 | Sterling Winthrop Inc. | Antipicornaviral agents |
US5498616A (en) | 1994-11-04 | 1996-03-12 | Cephalon, Inc. | Cysteine protease and serine protease inhibitors |
EP0820464A2 (en) * | 1995-03-31 | 1998-01-28 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
US5856530A (en) | 1996-05-14 | 1999-01-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
CA2254343A1 (en) | 1996-05-14 | 1997-11-20 | Agouron Pharmaceuticals, Inc. | Inhibitors of picornavirus 3c proteases and methods for their use and preparation |
WO1997049668A1 (en) | 1996-06-13 | 1997-12-31 | Smithkline Beecham Corporation | Inhibitiors of cysteine protease |
GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
PT975588E (pt) | 1997-03-28 | 2004-02-27 | Agouron Pharma | Compostos antipicornavirais, composicoes que os contem e metodos para a sua utilizacao |
US6331554B1 (en) | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
US6020371A (en) | 1997-03-28 | 2000-02-01 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds compositions containing them and methods for their use |
US5962487A (en) | 1997-12-16 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
DE69928140D1 (de) * | 1998-04-30 | 2005-12-08 | Agouron Pharma | Antipicornavirale Verbindungen, deren Herstellung und Verwendung |
US6369226B1 (en) | 1999-06-21 | 2002-04-09 | Agouron Pharmaceuticals, Inc. | Substituted benzamide inhibitors of rhinovirus 3C protease |
BR0012970A (pt) * | 1999-08-04 | 2002-04-30 | Agouron Pharma | Compostos e composições antipicornavirais, seus usos farmacêuticos e materiais para a sua sìntese |
CZ2002634A3 (cs) | 1999-08-24 | 2002-09-11 | Agouron Pharmaceuticals, Inc. | Účinné způsoby pro přípravu inhibitorů rhinoviru proteázy, klíčové meziprodukty a kontinuální membránový reaktor užitečný pro jejich přípravu |
PE20010517A1 (es) | 1999-08-24 | 2001-05-16 | Agouron Pharma | Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves |
PE20020157A1 (es) | 1999-12-03 | 2002-02-22 | Agouron Pharma | Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis |
EP1355878A2 (en) * | 2000-06-14 | 2003-10-29 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
-
2001
- 2001-04-11 PE PE2001000336A patent/PE20011277A1/es not_active Application Discontinuation
- 2001-04-11 PA PA20018515201A patent/PA8515201A1/es unknown
- 2001-04-12 MX MXPA02010195A patent/MXPA02010195A/es unknown
- 2001-04-12 CN CN01810359A patent/CN1431995A/zh active Pending
- 2001-04-12 WO PCT/US2001/012333 patent/WO2001079167A2/en not_active Application Discontinuation
- 2001-04-12 HU HU0300928A patent/HUP0300928A3/hu unknown
- 2001-04-12 CA CA002406475A patent/CA2406475A1/en not_active Abandoned
- 2001-04-12 KR KR1020027013804A patent/KR20030019350A/ko not_active Application Discontinuation
- 2001-04-12 BR BR0110077-7A patent/BR0110077A/pt not_active IP Right Cessation
- 2001-04-12 JP JP2001576769A patent/JP2003531139A/ja active Pending
- 2001-04-12 AU AU2001251639A patent/AU2001251639A1/en not_active Abandoned
- 2001-04-12 PL PL01365198A patent/PL365198A1/xx not_active Application Discontinuation
- 2001-04-12 EP EP01925037A patent/EP1274682A2/en not_active Withdrawn
- 2001-04-12 IL IL15224301A patent/IL152243A0/xx unknown
- 2001-04-12 US US09/834,783 patent/US6610730B2/en not_active Expired - Fee Related
- 2001-04-16 UY UY26666A patent/UY26666A1/es unknown
- 2001-04-17 SV SV2001000379A patent/SV2001000379A/es not_active Application Discontinuation
- 2001-04-17 AR ARP010101775A patent/AR028338A1/es not_active Application Discontinuation
-
2002
- 2002-10-14 ZA ZA200208257A patent/ZA200208257B/en unknown
-
2003
- 2003-05-12 US US10/435,082 patent/US6872745B2/en not_active Expired - Fee Related
-
2004
- 2004-11-12 US US10/986,109 patent/US20050101651A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2001251639A1 (en) | 2001-10-30 |
PE20011277A1 (es) | 2002-01-07 |
ZA200208257B (en) | 2003-07-25 |
CN1431995A (zh) | 2003-07-23 |
PL365198A1 (en) | 2004-12-27 |
BR0110077A (pt) | 2003-06-17 |
US20030225042A1 (en) | 2003-12-04 |
IL152243A0 (en) | 2003-05-29 |
PA8515201A1 (es) | 2002-10-24 |
AR028338A1 (es) | 2003-05-07 |
US6610730B2 (en) | 2003-08-26 |
WO2001079167A2 (en) | 2001-10-25 |
WO2001079167A3 (en) | 2002-02-28 |
MXPA02010195A (es) | 2003-04-25 |
US20020006943A1 (en) | 2002-01-17 |
CA2406475A1 (en) | 2001-10-25 |
US20050101651A1 (en) | 2005-05-12 |
HUP0300928A3 (en) | 2005-08-29 |
KR20030019350A (ko) | 2003-03-06 |
JP2003531139A (ja) | 2003-10-21 |
HUP0300928A2 (hu) | 2003-08-28 |
EP1274682A2 (en) | 2003-01-15 |
UY26666A1 (es) | 2001-11-30 |
US6872745B2 (en) | 2005-03-29 |
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