GR890100501A - Συν?ετικά πολυπεπτίδια και αντισώματα σχετιζόμενα προς τα πυρηνικά αντιγόνα του ιού Epstein-Barr. - Google Patents
Συν?ετικά πολυπεπτίδια και αντισώματα σχετιζόμενα προς τα πυρηνικά αντιγόνα του ιού Epstein-Barr.Info
- Publication number
- GR890100501A GR890100501A GR890100501A GR890100501A GR890100501A GR 890100501 A GR890100501 A GR 890100501A GR 890100501 A GR890100501 A GR 890100501A GR 890100501 A GR890100501 A GR 890100501A GR 890100501 A GR890100501 A GR 890100501A
- Authority
- GR
- Greece
- Prior art keywords
- barr virus
- epstein
- diagnostic methods
- nuclear antigen
- synthetic polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 108010008655 Epstein-Barr Virus Nuclear Antigens Proteins 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 1
- 102000019040 Nuclear Antigens Human genes 0.000 abstract 1
- 108010051791 Nuclear Antigens Proteins 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Περιγράφονται αντιγόνα, ανοσογόνα, εμβόλια, αντισώματα και ίδια διαγνωστικαί μέθοδοι και συστήματα σχετιζόμενα προς πυρηνικά αντιγόνα του ιού Epstein Barr (ΕΒΝΑ). Αι διαγνωστικαί μέθοδοι και τα συστήματα χρησιμοποιούν συνθετικόν πολυμερές πολυπεπτίδιον τυχαίας διατάξεως περιέχον από περίπου 6 έως περίπου 40 ρίζας αμινοξέων και έχον αλληλουχίαν αντιστοιχούσαν εις την αλληλουχίαν πολυπεπτιδικόν αντιγόνον κωδικοποιούμενον υπό του CMV. Αι διαγνωστικαί μέθοδοι και τα συστήματα είναι ιδιαιτέρως χρήσιμοι εις την διαπίστωσιν μολύνσεως υπό μονοπυρηνώσεως κατά την οξείαν αυτών φάση. ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/230,250 US5717065A (en) | 1984-08-08 | 1988-08-09 | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen |
Publications (1)
Publication Number | Publication Date |
---|---|
GR890100501A true GR890100501A (el) | 1991-12-30 |
Family
ID=22864499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR890100501A GR890100501A (el) | 1988-08-09 | 1989-08-08 | Συν?ετικά πολυπεπτίδια και αντισώματα σχετιζόμενα προς τα πυρηνικά αντιγόνα του ιού Epstein-Barr. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5717065A (el) |
EP (1) | EP0428629B1 (el) |
AT (1) | ATE134648T1 (el) |
AU (1) | AU643188B2 (el) |
CA (1) | CA1340446C (el) |
DE (1) | DE68925819T2 (el) |
DK (1) | DK175828B1 (el) |
ES (1) | ES2018909A6 (el) |
FI (1) | FI102381B1 (el) |
GR (1) | GR890100501A (el) |
NO (1) | NO309720B1 (el) |
PT (1) | PT91397B (el) |
WO (1) | WO1990001495A1 (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374517A (en) * | 1989-11-24 | 1994-12-20 | Council Of The Queensland Institute Of Medical Research | IM peptides |
JPH04310861A (ja) * | 1991-04-09 | 1992-11-02 | Kazuo Yanagi | 抗ebna抗体の測定方法および抗ebna抗体測定キット |
ES2221922T3 (es) * | 1992-09-14 | 2005-01-16 | Biomerieux B.V. | Peptidos del virus de epstein-barr y anticuerpos contra estos peptidos. |
US5833991A (en) * | 1995-04-10 | 1998-11-10 | Cobra Therapeutics, Ltd. | Glycine-containing sequences conferring invisibility to the immune system |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4654419A (en) * | 1984-08-08 | 1987-03-31 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4686282A (en) * | 1983-08-12 | 1987-08-11 | Immunetech, Inc. | Immunotherapeutic polypeptide agents which block immune complex binding to immunoglobulin Fc receptors |
US5116725A (en) * | 1984-08-08 | 1992-05-26 | Scripps Clinic And Research Foundation | Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides |
ZA846192B (en) * | 1984-08-09 | 1986-03-26 | Merck Patent Gmbh | Immunotherapeutic polypeptide agents |
-
1988
- 1988-08-09 US US07/230,250 patent/US5717065A/en not_active Expired - Lifetime
-
1989
- 1989-08-03 EP EP89911450A patent/EP0428629B1/en not_active Expired - Lifetime
- 1989-08-03 AT AT89911450T patent/ATE134648T1/de not_active IP Right Cessation
- 1989-08-03 DE DE68925819T patent/DE68925819T2/de not_active Expired - Fee Related
- 1989-08-03 WO PCT/US1989/003350 patent/WO1990001495A1/en active IP Right Grant
- 1989-08-03 AU AU44000/89A patent/AU643188B2/en not_active Ceased
- 1989-08-04 CA CA 607544 patent/CA1340446C/en not_active Expired - Lifetime
- 1989-08-07 PT PT91397A patent/PT91397B/pt not_active IP Right Cessation
- 1989-08-08 GR GR890100501A patent/GR890100501A/el unknown
- 1989-08-08 ES ES8902818A patent/ES2018909A6/es not_active Expired - Fee Related
-
1991
- 1991-02-07 FI FI910587A patent/FI102381B1/fi active
- 1991-02-07 DK DK199100211A patent/DK175828B1/da not_active IP Right Cessation
- 1991-02-07 NO NO910479A patent/NO309720B1/no unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4654419A (en) * | 1984-08-08 | 1987-03-31 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen |
Non-Patent Citations (11)
Title |
---|
CLAIMS SEARCHED COMPLETELY: 2,3,5,8 * |
CLAIMS SEARCHED INCOMPLETELY: 1,4,6,7 * |
J. EXP. MED., vol. 165, April 1987, pages 1026-1040; G. RHODES et al.: "Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen" * |
JOURNAL OF IMMUNOLOGY, vol. 134, no. 1, January 1985, pages 211-216; G. RHODES et al.: "Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen" * |
JOURNAL OF IMMUNOLOGY, vol. 138, no. 2, 15th January 1987, pages 593-599; H. RUMPOLD et al.: "The glycine-alanine repeating region is the major epitope of the Epstein-Barr nuclear antigen-1 (EBNA-1)" * |
JOURNAL OF VIROLOGY, vol. 38, no. 3, June 1981, pages 996-1004; B.C. STRNAD et al.: "Identification of an Epstein-Barr virus nuclear antigen by fluoroimmunoelectrophoresis and radioimmunoelectrophoresis" * |
JOURNAL OF VIROLOGY, vol. 44, no. 1, October 1982, pages 311-320; M. HELLER et al.: "Simple repeat sequence in Epstein-Barr virus DNA is transcribed in latent and productive infections" * |
JOURNAL OF VIROLOGY, vol. 57, no. 2, February 1986, pages 591-602, American Society for Microbiology; S.I. STAPRANS et al.: "2.2-Kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169" * |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 80, 1983, pages 7104-7108; P. BILLINGS et al.: "Antibodies to the Epstein-Barr virus nuclear antigen and to rheumatoid arthritis nuclear antigen identify the same polypeptide" * |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 80, September 1983, pages 5665-5669; K. HENNESSY et al.: "One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain" * |
THE JOURNAL OF INFECTIOUS DISEASES, vol. 154, no. 5, November 1986, pages 885-889; R. SMITH: "A synthetic peptide for detecting antibodies to Epstein-Barr virus nuclear antigen in sera from patients with infectious mononucleosis" * |
Also Published As
Publication number | Publication date |
---|---|
DE68925819T2 (de) | 1996-10-02 |
PT91397B (pt) | 1995-05-04 |
ATE134648T1 (de) | 1996-03-15 |
DK175828B1 (da) | 2005-03-14 |
DE68925819D1 (de) | 1996-04-04 |
WO1990001495A1 (en) | 1990-02-22 |
EP0428629B1 (en) | 1996-02-28 |
EP0428629A4 (en) | 1991-12-27 |
US5717065A (en) | 1998-02-10 |
FI102381B (fi) | 1998-11-30 |
DK21191A (da) | 1991-04-04 |
FI910587A0 (fi) | 1991-02-07 |
EP0428629A1 (en) | 1991-05-29 |
ES2018909A6 (es) | 1991-05-16 |
CA1340446C (en) | 1999-03-16 |
AU643188B2 (en) | 1993-11-11 |
NO910479L (no) | 1991-04-05 |
NO910479D0 (no) | 1991-02-07 |
DK21191D0 (da) | 1991-02-07 |
FI102381B1 (fi) | 1998-11-30 |
NO309720B1 (no) | 2001-03-19 |
AU4400089A (en) | 1990-03-05 |
PT91397A (pt) | 1990-03-08 |
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