GR880300123T1 - Bicyclic aromatic derivatives, process for their preparation and their use as medicines - Google Patents

Bicyclic aromatic derivatives, process for their preparation and their use as medicines

Info

Publication number
GR880300123T1
GR880300123T1 GR88300123T GR880300123T GR880300123T1 GR 880300123 T1 GR880300123 T1 GR 880300123T1 GR 88300123 T GR88300123 T GR 88300123T GR 880300123 T GR880300123 T GR 880300123T GR 880300123 T1 GR880300123 T1 GR 880300123T1
Authority
GR
Greece
Prior art keywords
represent
dimethylene
image
taken together
lower alkyl
Prior art date
Application number
GR88300123T
Other languages
English (en)
Inventor
Maignan Jean
Lang Gerard
Malle Gerard
Restle Serge
Shroot Braham Villa
Original Assignee
Cird
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cird filed Critical Cird
Publication of GR880300123T1 publication Critical patent/GR880300123T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/86—Ketones containing a keto group bound to a six-membered aromatic ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
GR88300123T 1986-07-17 1988-12-16 Bicyclic aromatic derivatives, process for their preparation and their use as medicines GR880300123T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8610423A FR2601670B1 (fr) 1986-07-17 1986-07-17 Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique

Publications (1)

Publication Number Publication Date
GR880300123T1 true GR880300123T1 (en) 1988-12-16

Family

ID=9337517

Family Applications (2)

Application Number Title Priority Date Filing Date
GR88300123T GR880300123T1 (en) 1986-07-17 1988-12-16 Bicyclic aromatic derivatives, process for their preparation and their use as medicines
GR91400157T GR3001455T3 (en) 1986-07-17 1991-02-07 Bicyclic aromatic derivatives, process for their preparation and their use as medicines

Family Applications After (1)

Application Number Title Priority Date Filing Date
GR91400157T GR3001455T3 (en) 1986-07-17 1991-02-07 Bicyclic aromatic derivatives, process for their preparation and their use as medicines

Country Status (17)

Country Link
US (1) US4833240A (el)
EP (1) EP0260162B1 (el)
JP (1) JP2731148B2 (el)
AT (1) ATE58367T1 (el)
AU (1) AU597396B2 (el)
CA (2) CA1328605C (el)
DE (2) DE260162T1 (el)
DK (1) DK171965B1 (el)
ES (1) ES2002463T3 (el)
FI (1) FI89261C (el)
FR (1) FR2601670B1 (el)
GR (2) GR880300123T1 (el)
IE (1) IE62598B1 (el)
NO (2) NO167141C (el)
NZ (1) NZ221112A (el)
PT (1) PT85339B (el)
ZA (1) ZA875261B (el)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU86387A1 (fr) * 1986-04-04 1987-12-07 Oreal Composes aromatiques,leur procede de preparation et leur utilisation en medicine humaine et veterinaire et en cosmetique
FR2599031B1 (fr) * 1986-05-23 1988-07-22 Oreal Nouveaux composes naphtyl aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique
US5264578A (en) * 1987-03-20 1993-11-23 Allergan, Inc. Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US4981508A (en) * 1989-01-23 1991-01-01 Uniroyal Chemical Company, Inc. 1,4-benzoxazin-3-one substituted uracils
US4877911A (en) * 1989-01-27 1989-10-31 Union Camp Corporation Process for preparing polyalkyl tetrahydronaphthalenes
US4877914A (en) * 1989-01-27 1989-10-31 Union Camp Corporation Process for preparing polyalkyl tetrahydronaphthalenes
US4877913A (en) * 1989-01-27 1989-10-31 Union Camp Corporation Process for preparing polyalkyl tetrahydronaphthalenes
US4877915A (en) * 1989-01-27 1989-10-31 Union Camp Corporation Process for preparing polyalkyl tetrahydronaphthalenes
US4877912A (en) * 1989-01-27 1989-10-31 Union Camp Corporation Process for preparing 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene
US4877916A (en) * 1989-01-27 1989-10-31 Union Camp Corporation Process for preparing polyalkyl tetrahydronaphthalenes
DE3903992A1 (de) * 1989-02-10 1990-08-16 Basf Ag Aromatische ketoverbindungen, ihre herstellung und arzneimittel sowie kosmetika daraus
US5194664A (en) * 1989-02-10 1993-03-16 Basf Aktiengesellschaft Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these
US5962731A (en) * 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
DE10199033I2 (de) * 1992-04-22 2003-01-09 Ligand Parmaceuticals Inc Retinoid-x Rezeptor selektive Verbindungen
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
JPH08506323A (ja) * 1992-11-25 1996-07-09 ラ ホヤ キャンサー リサーチ ファウンデーション Ｒｘｒホモダイマー形成ならびに架橋二環式芳香族化合物および調節遺伝子発現におけるそれらの使用
US5466861A (en) * 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
AU6225894A (en) * 1993-01-11 1994-08-15 Ligand Pharmaceuticals, Inc. Compounds having selectivity for retinoid x receptors
US5344959A (en) * 1993-05-18 1994-09-06 Allergan, Inc. Tetrahydronaphthyl and cyclopropyl substituted 1,3-butadienes having retinoid-like activity
AU2823395A (en) * 1994-06-07 1996-01-04 Sri International Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity
US5534641A (en) * 1994-12-29 1996-07-09 Allergan Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5648514A (en) 1994-12-29 1997-07-15 Allergan Substituted acetylenes having retinoid-like biological activity
US5610185A (en) * 1995-02-17 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services Method for the treatment of hyperproliferative epithelial skin diseases by topical application of hydroxylated aromatic protein cross-linking compounds
US5917082A (en) * 1995-06-06 1999-06-29 Allergan Sales, Inc. 2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5675033A (en) * 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6942980B1 (en) 1995-09-01 2005-09-13 Allergan, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5952345A (en) 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6218128B1 (en) 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en) * 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
ES2190479T3 (es) 1995-10-06 2003-08-01 Ligand Pharm Inc Moduladores de rxr selectivos a dimeros y metodos para su uso.
US5675024A (en) 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US20030219832A1 (en) * 1996-03-11 2003-11-27 Klein Elliott S. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
FR2746101B1 (fr) * 1996-03-14 1998-04-30 Composes bicycliques-aromatiques
US6555690B2 (en) 1996-06-21 2003-04-29 Allergan, Inc. Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en) 1996-06-21 1998-06-30 Allergan Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5741896A (en) 1996-06-21 1998-04-21 Allergan O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5763635A (en) * 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
FR2755965B1 (fr) * 1996-11-19 1998-12-18 Cird Galderma Composes biaromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
FR2768731B1 (fr) * 1997-09-25 1999-12-10 Cird Galderma Derives insatures en position -4 du 6-tert-butyl-1,1- dimethylindane et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
US6534545B1 (en) 1997-09-25 2003-03-18 Galderma Research & Development Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics
JP2003520758A (ja) * 1998-06-12 2003-07-08 リガンド・ファーマシューティカルズ・インコーポレイテッド 抗エストロゲン耐性乳癌のｒｘｒモジュレーターを用いた処置
FR2779720B1 (fr) * 1998-06-12 2002-08-16 Galderma Rech Dermatologique Nouveaux composes diarylselenures et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetologie
HUP0202814A3 (en) * 1999-08-27 2003-11-28 Ligand Pharmaceuticals Inc San Androgen receptor modulator compounds and methods for their preparation and pharmaceutical compositions containing them and their use
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
WO2001016133A2 (en) 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
CO5200852A1 (es) * 1999-09-14 2002-09-27 Lilly Co Eli Moduladores rxr con mejorado perfil farmacologico ceptores x de los retinoides
US6313107B1 (en) 2000-08-29 2001-11-06 Allergan Sales, Inc. Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI
US6369225B1 (en) 2000-08-29 2002-04-09 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6380256B1 (en) * 2000-08-29 2002-04-30 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
JP2006511547A (ja) * 2002-12-17 2006-04-06 ガルデルマ・リサーチ・アンド・デヴェロップメント・エス・エヌ・セ 塩基を使用する、溶媒中における可溶化レチノイドの化学的安定化方法
FR2848451B1 (fr) * 2002-12-17 2007-01-12 Galderma Res & Dev Procede de stabilisation chimique d'un retinoide solubilise et composition aqueuse obtenue selon le procede comprenant au moins un retinoide sous forme salifiee
US9050310B2 (en) * 2004-06-25 2015-06-09 Minas Theodore Coroneo Treatment of ocular lesions
US20060204474A1 (en) * 2005-02-25 2006-09-14 Coroneo Minas T Treatment of epithelial layer lesions
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
US9963439B2 (en) 2013-08-20 2018-05-08 University Of Washington Through Its Center For Commercialization Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase
US11045441B2 (en) 2015-10-13 2021-06-29 Wisconsin Alumni Research Foundation Use of retinoic acid and analogs thereof to treat central neural apneas
KR20200060459A (ko) * 2017-09-28 2020-05-29 존슨 앤드 존슨 컨수머 인코포레이티드 화장 조성물 및 피부 치료 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763233A (en) * 1971-08-17 1973-10-02 Sandoz Ag 7-substituted-hexahydro pleiadenes
JPS59196839A (ja) * 1983-04-21 1984-11-08 Sankyo Co Ltd フエニル酢酸誘導体
IL80270A0 (en) * 1985-10-11 1987-01-30 Cird Naphthalene derivatives,their preparation and pharmaceutical compositions containing them
LU86387A1 (fr) * 1986-04-04 1987-12-07 Oreal Composes aromatiques,leur procede de preparation et leur utilisation en medicine humaine et veterinaire et en cosmetique
FR2599031B1 (fr) * 1986-05-23 1988-07-22 Oreal Nouveaux composes naphtyl aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique

Also Published As

Publication number Publication date
NO872983L (no) 1988-01-18
ES2002463T3 (es) 1994-01-16
IE62598B1 (en) 1995-02-08
JP2731148B2 (ja) 1998-03-25
NZ221112A (en) 1990-08-28
ZA875261B (en) 1988-03-30
FR2601670B1 (fr) 1988-10-07
DK370787A (da) 1988-01-18
FI89261C (fi) 1993-09-10
AU7590387A (en) 1988-02-04
US4833240A (en) 1989-05-23
ES2002463A4 (es) 1988-08-16
NO902453D0 (no) 1990-06-01
DE3766198D1 (de) 1990-12-20
PT85339A (fr) 1987-08-01
ATE58367T1 (de) 1990-11-15
NO872983D0 (no) 1987-07-16
PT85339B (pt) 1990-04-30
CA1328605C (fr) 1994-04-19
IE871922L (en) 1988-01-17
FI873148A0 (fi) 1987-07-16
NO168031B (no) 1991-09-30
DK171965B1 (da) 1997-09-01
GR3001455T3 (en) 1992-10-08
AU597396B2 (en) 1990-05-31
EP0260162B1 (fr) 1990-11-14
EP0260162A1 (fr) 1988-03-16
NO167141B (no) 1991-07-01
JPS6330433A (ja) 1988-02-09
CA1296352C (fr) 1992-02-25
DE260162T1 (de) 1988-09-01
NO168031C (no) 1992-01-08
FI89261B (fi) 1993-05-31
NO902453L (no) 1988-01-18
DK370787D0 (da) 1987-07-16
FR2601670A1 (fr) 1988-01-22
NO167141C (no) 1991-10-09
FI873148A (fi) 1988-01-18

Similar Documents

Publication Publication Date Title
GR3001455T3 (en) Bicyclic aromatic derivatives, process for their preparation and their use as medicines
AU588385B2 (en) New bicyclic naphthalene derivatives, the process for the preparation of them and the use of them in human and veterinary medicine and in cosmetics
NO162284C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive spiro(4. (3+n))-2-aza-alkan-3-karboksylsyre-derivater.
ATE2622T1 (de) 2-niedrigalkyl-7-substituierte-2 oder 3-cephem-4- carbonsaeuren, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
GR3001972T3 (en) Polycyclic aromatic compounds, process for their preparation and their use in human and animal medicine and in cosmetics
GR890300055T1 (en) Aromatic derivatives of butyric acid, process for their preparation and their cosmetic and pharmaceutical use