GR78733B - - Google Patents

Info

Publication number
GR78733B
GR78733B GR72936A GR830172936A GR78733B GR 78733 B GR78733 B GR 78733B GR 72936 A GR72936 A GR 72936A GR 830172936 A GR830172936 A GR 830172936A GR 78733 B GR78733 B GR 78733B
Authority
GR
Greece
Application number
GR72936A
Other languages
Greek (el)
Inventor
Michael G Goodman
William O Weigle
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/439,846 external-priority patent/US4539205A/en
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of GR78733B publication Critical patent/GR78733B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GR72936A 1982-11-09 1983-11-09 GR78733B (en:Method)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/439,846 US4539205A (en) 1982-11-09 1982-11-09 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US06/546,679 US4643992A (en) 1982-11-09 1983-11-01 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives

Publications (1)

Publication Number Publication Date
GR78733B true GR78733B (en:Method) 1984-10-02

Family

ID=27032191

Family Applications (1)

Application Number Title Priority Date Filing Date
GR72936A GR78733B (en:Method) 1982-11-09 1983-11-09

Country Status (15)

Country Link
US (1) US4643992A (en:Method)
EP (1) EP0112632B1 (en:Method)
AU (1) AU568325B2 (en:Method)
CA (1) CA1236401A (en:Method)
DE (1) DE3382156D1 (en:Method)
DK (1) DK167898B1 (en:Method)
ES (1) ES8601301A1 (en:Method)
FI (1) FI87733C (en:Method)
GR (1) GR78733B (en:Method)
IE (1) IE56701B1 (en:Method)
IL (1) IL70164A (en:Method)
NO (1) NO174215C (en:Method)
NZ (1) NZ206208A (en:Method)
PT (1) PT77636B (en:Method)
WO (1) WO1984001898A1 (en:Method)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849411A (en) * 1982-11-09 1989-07-18 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5476659A (en) * 1982-11-09 1995-12-19 The Scripps Research Institute Cancerous B cell treatment using substituted nucleoside derivatives
US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
US5093318A (en) * 1983-11-01 1992-03-03 Scripps Clinic And Research Foundation Immunostimulating guanosine derivatives and their pharmaceutical compositions
US4900675A (en) * 1983-11-01 1990-02-13 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-β-aldoglycosidyl) derivatives
FR2560212B1 (fr) * 1984-02-24 1989-12-29 Unicet Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods
ZA869297B (en) * 1985-12-13 1987-11-25 Scripps Clinic Res Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-beta-aldoglycosidyl)derivatives
US7307166B1 (en) 1987-10-28 2007-12-11 Wellstat Therapeutics Corporation Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
US4880784A (en) * 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US4902985A (en) * 1988-02-25 1990-02-20 Raytheon Company Microwave reflectiion amplifiers having increased bandwidth
GB2216416B (en) * 1988-03-11 1992-06-24 Sandoz Ltd Nucleobase source for the stimulation of the immune system
KR900700156A (ko) * 1988-04-27 1990-08-11 원본미기재 개선된 방사선 치료법
AU5845594A (en) * 1992-11-13 1994-06-08 Scripps Research Institute, The Cancerous b cell treatment using substituted nucleoside derivatives
US5441942A (en) * 1994-05-27 1995-08-15 The Scripps Research Institute 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect
US5786359A (en) * 1994-05-27 1998-07-28 The Scripps Research Institute N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US20030100520A1 (en) * 1997-01-21 2003-05-29 Philip Needleman Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination
WO1999057120A1 (en) 1998-05-04 1999-11-11 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
WO2000062803A2 (en) * 1999-04-15 2000-10-26 Board Of Regents, The University Of Texas System ppGpp AND pppGpp AS IMMUNOMODULATORY AGENTS
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) * 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
WO2002004448A2 (en) 2000-07-07 2002-01-17 Neotherapeutics, Inc. Methods for treatment of drug-induced peripheral neuropathy and related conditions
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
WO2002102307A2 (en) * 2001-06-15 2002-12-27 Ribapharm Nucleoside vaccine adjuvants
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US7351413B2 (en) * 2002-02-21 2008-04-01 Lorantis, Limited Stabilized HBc chimer particles as immunogens for chronic hepatitis
WO2005025583A2 (en) * 2003-09-05 2005-03-24 Anadys Pharmaceuticals, Inc. Tlr7 ligands for the treatment of hepatitis c
ES2459368T3 (es) 2004-12-17 2014-05-09 Anadys Pharmaceuticals, Inc. Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos
ATE474842T1 (de) 2005-11-21 2010-08-15 Anadys Pharmaceuticals Inc Neues verfahren zur herstellung von 5-amino-3h- thiazoloä4,5-düpyrimidin-2-on
ATE496924T1 (de) * 2006-06-22 2011-02-15 Anadys Pharmaceuticals Inc Prodrugs von 5-amino-3-(3'-deoxy-beta-d- ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion
BRPI0714831A2 (pt) 2006-07-18 2013-04-02 Anadys Pharmaceuticals Inc composto, composiÇço farmacÊutica e mÉtodos de modulaÇço de atividades imuno da citoquina em paciente, de tratamento de infecÇço de vÍrus c da hepatite em paciente e de desordem relacionada com proliferaÇço em mamÍfero necessitado do mesmo
MX2010001284A (es) 2007-08-02 2010-08-31 Biondvax Pharmaceuticals Ltd Vacunas contra la influenza con multiepitope multimerico.
CA2744739A1 (en) 2007-12-03 2009-06-11 President And Fellows Of Harvard College Chlamydia antigens
CA2745205A1 (en) 2008-12-03 2010-06-10 Protea Vaccine Technologies Ltd. Glutamyl trna synthetase (gts) fragments
PE20120106A1 (es) 2008-12-09 2012-02-20 Gilead Sciences Inc Moduladores de receptores tipo toll
WO2011067758A2 (en) 2009-12-02 2011-06-09 Protea Vaccine Technologies Ltd. Immunogenic fragments and multimers from streptococcus pneumoniae proteins
CA2828068C (en) 2011-02-22 2019-03-19 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
EP3492095A1 (en) 2012-04-01 2019-06-05 Technion Research & Development Foundation Limited Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
CA2944768C (en) 2014-04-03 2022-08-30 Biondvax Pharmaceuticals Ltd. Compositions of multimeric-multiepitope influenza polypeptides and their production
KR20190104438A (ko) 2014-07-11 2019-09-09 길리애드 사이언시즈, 인코포레이티드 Hiv의 치료를 위한 톨-유사 수용체의 조정제
CN106715431A (zh) 2014-09-16 2017-05-24 吉利德科学公司 Toll样受体调节剂的固体形式

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174077A (en) * 1967-02-18 1969-12-10 Ajinomoto Kk Process for Preparing 8-Mercaptopurine Derivatives

Also Published As

Publication number Publication date
DK167898B1 (da) 1994-01-03
EP0112632A3 (en) 1985-01-23
EP0112632A2 (en) 1984-07-04
NO174215B (no) 1993-12-20
DK334884A (da) 1984-07-06
EP0112632B1 (en) 1991-02-06
PT77636A (en) 1983-12-01
IL70164A0 (en) 1984-02-29
IE56701B1 (en) 1991-11-06
IL70164A (en) 1988-06-30
FI87733C (fi) 1993-02-25
FI87733B (fi) 1992-11-13
DE3382156D1 (de) 1991-03-14
NZ206208A (en) 1987-03-31
ES527138A0 (es) 1985-11-01
ES8601301A1 (es) 1985-11-01
NO174215C (no) 1994-03-30
AU568325B2 (en) 1987-12-24
DK334884D0 (da) 1984-07-06
AU2330284A (en) 1984-06-04
NO842765L (no) 1984-07-06
PT77636B (en) 1986-03-19
FI842748L (fi) 1984-07-09
US4643992A (en) 1987-02-17
IE832605L (en) 1984-05-09
FI842748A0 (fi) 1984-07-09
WO1984001898A1 (en) 1984-05-24
CA1236401A (en) 1988-05-10

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