FI842748A0 - Modulering av djurcellers reaktioner med preparat innehaollande 8-substituerade guanidderivat. - Google Patents

Modulering av djurcellers reaktioner med preparat innehaollande 8-substituerade guanidderivat.

Info

Publication number
FI842748A0
FI842748A0 FI842748A FI842748A FI842748A0 FI 842748 A0 FI842748 A0 FI 842748A0 FI 842748 A FI842748 A FI 842748A FI 842748 A FI842748 A FI 842748A FI 842748 A0 FI842748 A0 FI 842748A0
Authority
FI
Finland
Prior art keywords
reaktioner
modulering
guanidderivat
djurcellers
substituerade
Prior art date
Application number
FI842748A
Other languages
English (en)
Other versions
FI87733C (fi
FI87733B (fi
FI842748A (fi
Inventor
Michael G Goodman
William O Weigle
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/439,846 external-priority patent/US4539205A/en
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of FI842748A0 publication Critical patent/FI842748A0/fi
Publication of FI842748A publication Critical patent/FI842748A/fi
Application granted granted Critical
Publication of FI87733B publication Critical patent/FI87733B/fi
Publication of FI87733C publication Critical patent/FI87733C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
FI842748A 1982-11-09 1984-07-09 Foerfarande foer modulering av djurcellers reaktioner in vitro med preparat innehaollande 8-substituerade guaninderivat FI87733C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US43984682 1982-11-09
US06/439,846 US4539205A (en) 1982-11-09 1982-11-09 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US54667983 1983-11-01
US06/546,679 US4643992A (en) 1982-11-09 1983-11-01 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
PCT/US1983/001722 WO1984001898A1 (en) 1982-11-09 1983-11-07 Modulation of animal cellular responses with compositions containng 8-substituted guanine derivatives
US8301722 1983-11-07

Publications (4)

Publication Number Publication Date
FI842748A0 true FI842748A0 (fi) 1984-07-09
FI842748A FI842748A (fi) 1984-07-09
FI87733B FI87733B (fi) 1992-11-13
FI87733C FI87733C (fi) 1993-02-25

Family

ID=27032191

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842748A FI87733C (fi) 1982-11-09 1984-07-09 Foerfarande foer modulering av djurcellers reaktioner in vitro med preparat innehaollande 8-substituerade guaninderivat

Country Status (15)

Country Link
US (1) US4643992A (fi)
EP (1) EP0112632B1 (fi)
AU (1) AU568325B2 (fi)
CA (1) CA1236401A (fi)
DE (1) DE3382156D1 (fi)
DK (1) DK167898B1 (fi)
ES (1) ES527138A0 (fi)
FI (1) FI87733C (fi)
GR (1) GR78733B (fi)
IE (1) IE56701B1 (fi)
IL (1) IL70164A (fi)
NO (1) NO174215C (fi)
NZ (1) NZ206208A (fi)
PT (1) PT77636B (fi)
WO (1) WO1984001898A1 (fi)

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US5476659A (en) * 1982-11-09 1995-12-19 The Scripps Research Institute Cancerous B cell treatment using substituted nucleoside derivatives
US4849411A (en) * 1982-11-09 1989-07-18 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5093318A (en) * 1983-11-01 1992-03-03 Scripps Clinic And Research Foundation Immunostimulating guanosine derivatives and their pharmaceutical compositions
US4900675A (en) * 1983-11-01 1990-02-13 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-β-aldoglycosidyl) derivatives
US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
FR2560212B1 (fr) * 1984-02-24 1989-12-29 Unicet Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods
ZA869297B (en) * 1985-12-13 1987-11-25 Scripps Clinic Res Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-beta-aldoglycosidyl)derivatives
US6060459A (en) * 1987-10-28 2000-05-09 Pro-Neuron, Inc. Enhancing blood cell count with oxypurine nucleosides
US4880784A (en) * 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US4902985A (en) * 1988-02-25 1990-02-20 Raytheon Company Microwave reflectiion amplifiers having increased bandwidth
GB2216416B (en) * 1988-03-11 1992-06-24 Sandoz Ltd Nucleobase source for the stimulation of the immune system
AU3578189A (en) * 1988-04-27 1989-11-24 Immunomedics Inc. Improved radiotherapy
WO1994011003A1 (en) * 1992-11-13 1994-05-26 The Scripps Research Institute Cancerous b cell treatment using substituted nucleoside derivatives
US5441942A (en) * 1994-05-27 1995-08-15 The Scripps Research Institute 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect
US5786359A (en) * 1994-05-27 1998-07-28 The Scripps Research Institute N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US20030100520A1 (en) * 1997-01-21 2003-05-29 Philip Needleman Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination
US6303617B1 (en) 1998-05-04 2001-10-16 Neotherapeutics, Inc. Serotonin-like 9-substituted hypoxanthine and methods of use
AU4244400A (en) * 1999-04-15 2000-11-02 Board Of Regents, The University Of Texas System Ppgpp and pppgpp as immunomodulatory agents
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) * 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
DE60144123D1 (de) 2000-07-07 2011-04-07 Spectrum Pharmaceuticals Inc Verfahren zur Behandlung von Arzneimittelinduzierter peripherer Neuropathie und verwandten Krankheitsformen
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
US6759427B2 (en) 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20040191214A1 (en) * 2001-06-15 2004-09-30 Johnson Lau Nucleoside vaccine adjuvants
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US7351413B2 (en) * 2002-02-21 2008-04-01 Lorantis, Limited Stabilized HBc chimer particles as immunogens for chronic hepatitis
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US8637053B2 (en) 2007-12-03 2014-01-28 President And Fellows Of Harvard College Chlamydia antigens
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CN102272134B (zh) 2008-12-09 2013-10-16 吉里德科学公司 Toll样受体调节剂
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CN110305133A (zh) 2014-09-16 2019-10-08 吉利德科学公司 Toll样受体调节剂的固体形式

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174077A (en) * 1967-02-18 1969-12-10 Ajinomoto Kk Process for Preparing 8-Mercaptopurine Derivatives

Also Published As

Publication number Publication date
DE3382156D1 (de) 1991-03-14
PT77636B (en) 1986-03-19
ES8601301A1 (es) 1985-11-01
DK167898B1 (da) 1994-01-03
NO174215B (no) 1993-12-20
NO842765L (no) 1984-07-06
GR78733B (fi) 1984-10-02
NO174215C (no) 1994-03-30
US4643992A (en) 1987-02-17
PT77636A (en) 1983-12-01
IL70164A (en) 1988-06-30
FI87733C (fi) 1993-02-25
AU2330284A (en) 1984-06-04
WO1984001898A1 (en) 1984-05-24
ES527138A0 (es) 1985-11-01
EP0112632A3 (en) 1985-01-23
FI87733B (fi) 1992-11-13
EP0112632B1 (en) 1991-02-06
DK334884A (da) 1984-07-06
IL70164A0 (en) 1984-02-29
DK334884D0 (da) 1984-07-06
IE56701B1 (en) 1991-11-06
IE832605L (en) 1984-05-09
FI842748A (fi) 1984-07-09
CA1236401A (en) 1988-05-10
EP0112632A2 (en) 1984-07-04
AU568325B2 (en) 1987-12-24
NZ206208A (en) 1987-03-31

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MA Patent expired

Owner name: SCRIPPS CLINIC AND RESEARCH FOUNDATION