ES8601301A1 - Un metodo para producir celulas cuyas respuestas inmunologicas humorales especificas de antigeno han sido moduladas. - Google Patents
Un metodo para producir celulas cuyas respuestas inmunologicas humorales especificas de antigeno han sido moduladas.Info
- Publication number
- ES8601301A1 ES8601301A1 ES527138A ES527138A ES8601301A1 ES 8601301 A1 ES8601301 A1 ES 8601301A1 ES 527138 A ES527138 A ES 527138A ES 527138 A ES527138 A ES 527138A ES 8601301 A1 ES8601301 A1 ES 8601301A1
- Authority
- ES
- Spain
- Prior art keywords
- medicament
- manufacture
- substituted guanine
- aldose
- cellular responses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
METODO PARA PRODUCIR CELULAS CUYAS RESPUESTAS INMUNOLOGICAS HUMORALES ESPECIFICAS DE ANTIGENO HAN SIDO MODULADAS. COMPRENDE: A) INTRODUCIR EN UNA GUANINA QUE NO POSEA FUNCIONALIDAD CARGADA ELECTRICAMENTE A TEMPERATURA Y PRESION AMBIENTE UN 8-SUSTITUYENTE CON UNA UNION SULFIDO EN POSICION 8 QUE POSEE UN EFECTO INDUCTOR DE LA ACEPTACION DE ELECTRONES SUPERIOR AL DEL H Y TIENE MENOS DE 15 ATOMOS PARA FORMAR UN DERIVADO DE GUANINA 8-SUSTITUIDA COMO 8-BROMOGUANOSINA 8-MERCAPTOGUANOSINA Y OTRAS; B) UNIR LA POSICION 9 DEL DERIVADO OBTENIDO EN A) CON LA POSICION 1 DE UNA ALDOSA DE C 5 A 6 DE FORMULA (I) A TEMPERATURA Y PRESION AMBIENTE. SIENDO: R1 H HIDROXI Y OTROS; R2 Y R3 HIDROXI METOXI Y OTROS; R4 H METILO Y OTROS; Y N 0 O 1; C) COMBINAR EL PRODUCTO DE B) CON UNA CANTIDAD DILUYENTE DE UN VEHICULO FISIOLOGICAMENTE TOLERABLE; Y D) HACER REACCIONAR EL PRODUCTO DE C) CON UNA CELULA PARA MODULAR SU RESPUESTA INMUNOLOGICA HUMORAL ESPECIFICA DEL ANTIGENO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/439,846 US4539205A (en) | 1982-11-09 | 1982-11-09 | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US06/546,679 US4643992A (en) | 1982-11-09 | 1983-11-01 | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES527138A0 ES527138A0 (es) | 1985-11-01 |
ES8601301A1 true ES8601301A1 (es) | 1985-11-01 |
Family
ID=27032191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527138A Expired ES8601301A1 (es) | 1982-11-09 | 1983-11-08 | Un metodo para producir celulas cuyas respuestas inmunologicas humorales especificas de antigeno han sido moduladas. |
Country Status (15)
Country | Link |
---|---|
US (1) | US4643992A (es) |
EP (1) | EP0112632B1 (es) |
AU (1) | AU568325B2 (es) |
CA (1) | CA1236401A (es) |
DE (1) | DE3382156D1 (es) |
DK (1) | DK167898B1 (es) |
ES (1) | ES8601301A1 (es) |
FI (1) | FI87733C (es) |
GR (1) | GR78733B (es) |
IE (1) | IE56701B1 (es) |
IL (1) | IL70164A (es) |
NO (1) | NO174215C (es) |
NZ (1) | NZ206208A (es) |
PT (1) | PT77636B (es) |
WO (1) | WO1984001898A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4849411A (en) * | 1982-11-09 | 1989-07-18 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US5476659A (en) * | 1982-11-09 | 1995-12-19 | The Scripps Research Institute | Cancerous B cell treatment using substituted nucleoside derivatives |
US5093318A (en) * | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
US4900675A (en) * | 1983-11-01 | 1990-02-13 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-β-aldoglycosidyl) derivatives |
US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
ZA869297B (en) * | 1985-12-13 | 1987-11-25 | Scripps Clinic Res | Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-beta-aldoglycosidyl)derivatives |
US6060459A (en) * | 1987-10-28 | 2000-05-09 | Pro-Neuron, Inc. | Enhancing blood cell count with oxypurine nucleosides |
US4880784A (en) * | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
US4902985A (en) * | 1988-02-25 | 1990-02-20 | Raytheon Company | Microwave reflectiion amplifiers having increased bandwidth |
GB2216416B (en) * | 1988-03-11 | 1992-06-24 | Sandoz Ltd | Nucleobase source for the stimulation of the immune system |
WO1989010158A1 (en) * | 1988-04-27 | 1989-11-02 | Immunomedics, Inc. | Improved radiotherapy |
AU5845594A (en) * | 1992-11-13 | 1994-06-08 | Scripps Research Institute, The | Cancerous b cell treatment using substituted nucleoside derivatives |
US5441942A (en) * | 1994-05-27 | 1995-08-15 | The Scripps Research Institute | 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect |
US5786359A (en) * | 1994-05-27 | 1998-07-28 | The Scripps Research Institute | N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines |
US6338963B1 (en) | 1994-07-25 | 2002-01-15 | Neotherapeutics, Inc. | Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis |
US20030100520A1 (en) * | 1997-01-21 | 2003-05-29 | Philip Needleman | Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination |
WO1999057120A1 (en) | 1998-05-04 | 1999-11-11 | Neotherapeutics, Inc. | Novel serotonin-like 9-substituted hypoxanthine and methods of use |
AU4244400A (en) * | 1999-04-15 | 2000-11-02 | Board Of Regents, The University Of Texas System | Ppgpp and pppgpp as immunomodulatory agents |
US6288069B1 (en) | 1999-11-16 | 2001-09-11 | Neotherapeutics, Inc. | Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue |
US6407237B1 (en) | 2001-02-21 | 2002-06-18 | Neotherapeutics, Inc. | Crystal forms of 9-substituted hypoxanthine derivatives |
US6849735B1 (en) * | 2000-06-23 | 2005-02-01 | Merck Eprova Ag | Methods of synthesis for 9-substituted hypoxanthine derivatives |
US6630478B2 (en) | 2000-07-07 | 2003-10-07 | Neotherapeutics, Inc. | Methods for treatment of drug-induced peripheral neuropathy |
US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
US6759427B2 (en) * | 2001-04-20 | 2004-07-06 | Spectrum Pharmaceuticals, Inc. | Synthesis and methods of use of tetrahydroindolone analogues and derivatives |
JP2005509591A (ja) * | 2001-06-15 | 2005-04-14 | リバファーム・インコーポレイテッド | ヌクレオシドワクチンアジュバント |
US20030055249A1 (en) * | 2001-07-17 | 2003-03-20 | Fick David B. | Synthesis and methods of use of pyrimidine analogues and derivatives |
US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
OA13310A (en) * | 2003-09-05 | 2007-04-13 | Anadys Pharmaceuticals Inc | TLR7 ligands for the treatment of hepatitis C. |
ES2525567T3 (es) * | 2004-12-17 | 2014-12-26 | Anadys Pharmaceuticals, Inc. | Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos |
SG152296A1 (en) | 2005-11-21 | 2009-05-29 | Anadys Pharmaceuticals Inc | Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2- one |
CA2655904C (en) * | 2006-06-22 | 2014-11-18 | Anadys Pharmaceuticals, Inc. | Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione |
EP2040712B1 (en) | 2006-07-18 | 2011-03-02 | Anadys Pharmaceuticals, Inc. | Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines |
DK2173376T3 (en) * | 2007-08-02 | 2015-06-29 | Biondvax Pharmaceuticals Ltd | Multimeric multi-epitope influenza vaccines |
AU2008331800A1 (en) | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
US20110236470A1 (en) | 2008-12-03 | 2011-09-29 | Yaffa Mizrachi Nebenzahl | GLUTAMYL tRNA SYNTHETASE (GtS) FRAGMENTS |
ES2623794T3 (es) | 2008-12-09 | 2017-07-12 | Gilead Sciences, Inc. | Intermedios para la preparación de moduladores de receptores tipo toll |
WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
AU2011360572B2 (en) | 2011-02-22 | 2017-03-02 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
EP3492095A1 (en) | 2012-04-01 | 2019-06-05 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
CN106163553B (zh) | 2014-04-03 | 2021-07-23 | 彼昂德瓦克斯医药有限公司 | 多聚体-多表位流感多肽的组合物及其产生 |
US11116774B2 (en) | 2014-07-11 | 2021-09-14 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of HIV |
US9738646B2 (en) | 2014-09-16 | 2017-08-22 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1174077A (en) * | 1967-02-18 | 1969-12-10 | Ajinomoto Kk | Process for Preparing 8-Mercaptopurine Derivatives |
-
1983
- 1983-11-01 US US06/546,679 patent/US4643992A/en not_active Expired - Lifetime
- 1983-11-07 WO PCT/US1983/001722 patent/WO1984001898A1/en active IP Right Grant
- 1983-11-07 AU AU23302/84A patent/AU568325B2/en not_active Expired
- 1983-11-08 CA CA000440679A patent/CA1236401A/en not_active Expired
- 1983-11-08 IE IE2605/83A patent/IE56701B1/en not_active IP Right Cessation
- 1983-11-08 ES ES527138A patent/ES8601301A1/es not_active Expired
- 1983-11-08 DE DE8383306791T patent/DE3382156D1/de not_active Expired - Lifetime
- 1983-11-08 IL IL70164A patent/IL70164A/xx not_active IP Right Cessation
- 1983-11-08 EP EP83306791A patent/EP0112632B1/en not_active Expired - Lifetime
- 1983-11-09 NZ NZ206208A patent/NZ206208A/en unknown
- 1983-11-09 PT PT77636A patent/PT77636B/pt unknown
- 1983-11-09 GR GR72936A patent/GR78733B/el unknown
-
1984
- 1984-07-06 DK DK334884A patent/DK167898B1/da not_active IP Right Cessation
- 1984-07-06 NO NO842765A patent/NO174215C/no not_active IP Right Cessation
- 1984-07-09 FI FI842748A patent/FI87733C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK334884A (da) | 1984-07-06 |
CA1236401A (en) | 1988-05-10 |
AU2330284A (en) | 1984-06-04 |
NO174215B (no) | 1993-12-20 |
FI87733C (fi) | 1993-02-25 |
FI842748A (fi) | 1984-07-09 |
EP0112632A3 (en) | 1985-01-23 |
US4643992A (en) | 1987-02-17 |
NO842765L (no) | 1984-07-06 |
AU568325B2 (en) | 1987-12-24 |
ES527138A0 (es) | 1985-11-01 |
EP0112632B1 (en) | 1991-02-06 |
FI87733B (fi) | 1992-11-13 |
EP0112632A2 (en) | 1984-07-04 |
DK334884D0 (da) | 1984-07-06 |
IL70164A0 (en) | 1984-02-29 |
IE832605L (en) | 1984-05-09 |
DE3382156D1 (de) | 1991-03-14 |
GR78733B (es) | 1984-10-02 |
DK167898B1 (da) | 1994-01-03 |
NZ206208A (en) | 1987-03-31 |
FI842748A0 (fi) | 1984-07-09 |
PT77636A (en) | 1983-12-01 |
PT77636B (en) | 1986-03-19 |
WO1984001898A1 (en) | 1984-05-24 |
NO174215C (no) | 1994-03-30 |
IE56701B1 (en) | 1991-11-06 |
IL70164A (en) | 1988-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20050712 |