ES453237A1 - Un procedimiento para la produccion de una preparacion anti-hipertensiva. - Google Patents
Un procedimiento para la produccion de una preparacion anti-hipertensiva.Info
- Publication number
- ES453237A1 ES453237A1 ES453237A ES453237A ES453237A1 ES 453237 A1 ES453237 A1 ES 453237A1 ES 453237 A ES453237 A ES 453237A ES 453237 A ES453237 A ES 453237A ES 453237 A1 ES453237 A1 ES 453237A1
- Authority
- ES
- Spain
- Prior art keywords
- amidino
- pyridazine
- dichlorophenyl
- acetamide
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un procedimiento para la producción de una preparación antihipertensiva, caracterizado porque consiste en : a) hacer reaccionar 3-cloro-6-benzoil-5,6,7,8-tetrahidro(4,3-c) piridazina con hidracina, preferiblemente en un disolvente inerte a una temperatura comprendida entre la ambiente y 180ºC para preparar el correspondiente antihipertensivo de piridazina; b) hacer reaccionar el ester alquilico del acido 2-(2,6-diclorofenil)-aceito con guanidina, preferiblemente en un disolvente inerte a una temperatura comprendida entre la ambiente y 180ºC, para preparar N-ami-dino-2(2,6 -dicorofenil) acetaminia; y c) combinar adecuadamente los productos obtenidos en las etapas a) y b).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1471875 | 1975-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453237A1 true ES453237A1 (es) | 1978-02-16 |
Family
ID=4403273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453237A Expired ES453237A1 (es) | 1975-11-13 | 1976-11-11 | Un procedimiento para la produccion de una preparacion anti-hipertensiva. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4152435A (es) |
| JP (1) | JPS5261233A (es) |
| AU (1) | AU513467B2 (es) |
| BE (1) | BE848276A (es) |
| CS (1) | CS212780B2 (es) |
| ES (1) | ES453237A1 (es) |
| FR (1) | FR2331333A1 (es) |
| GB (1) | GB1565686A (es) |
| HK (1) | HK3383A (es) |
| HU (1) | HU175415B (es) |
| IE (1) | IE44751B1 (es) |
| IL (1) | IL50895A (es) |
| MY (1) | MY8400061A (es) |
| NL (1) | NL7612423A (es) |
| NZ (1) | NZ182604A (es) |
| PH (1) | PH13718A (es) |
| PT (1) | PT65836B (es) |
| SE (1) | SE418800B (es) |
| SG (1) | SG63282G (es) |
| ZA (1) | ZA766791B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680300A (en) * | 1985-01-10 | 1987-07-14 | Syntex (U.S.A.) Inc. | Anti-inflammatory guanidines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH479559A (de) * | 1967-09-26 | 1969-10-15 | Wander Ag Dr A | Verfahren zur Herstellung von Acylguanidinen |
| SE400557B (sv) * | 1971-05-11 | 1978-04-03 | Sandoz Ag | Forfarande for framstellning av nya kondenserade pyridaziner |
| US3954754A (en) * | 1971-05-11 | 1976-05-04 | Sandoz Ltd. | 3-Hydrazino-cycloalkyl[c]pyridazines |
-
1976
- 1976-11-05 SE SE7612369A patent/SE418800B/xx unknown
- 1976-11-08 US US05/739,658 patent/US4152435A/en not_active Expired - Lifetime
- 1976-11-09 NL NL7612423A patent/NL7612423A/xx not_active Application Discontinuation
- 1976-11-11 NZ NZ182604A patent/NZ182604A/xx unknown
- 1976-11-11 CS CS767279A patent/CS212780B2/cs unknown
- 1976-11-11 HU HU76SA2989A patent/HU175415B/hu unknown
- 1976-11-11 IL IL50895A patent/IL50895A/xx unknown
- 1976-11-11 JP JP51134731A patent/JPS5261233A/ja active Pending
- 1976-11-11 ES ES453237A patent/ES453237A1/es not_active Expired
- 1976-11-11 IE IE2491/76A patent/IE44751B1/en unknown
- 1976-11-12 AU AU19597/76A patent/AU513467B2/en not_active Expired
- 1976-11-12 GB GB47175/76A patent/GB1565686A/en not_active Expired
- 1976-11-12 PT PT65836A patent/PT65836B/pt unknown
- 1976-11-12 ZA ZA00766791A patent/ZA766791B/xx unknown
- 1976-11-12 BE BE172302A patent/BE848276A/xx not_active IP Right Cessation
- 1976-11-12 PH PH19124A patent/PH13718A/en unknown
- 1976-11-15 FR FR7634280A patent/FR2331333A1/fr active Granted
-
1982
- 1982-12-23 SG SG632/82A patent/SG63282G/en unknown
-
1983
- 1983-01-20 HK HK33/83A patent/HK3383A/xx unknown
-
1984
- 1984-12-30 MY MY61/84A patent/MY8400061A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE44751L (en) | 1977-05-13 |
| SE7612369L (sv) | 1977-05-14 |
| FR2331333A1 (fr) | 1977-06-10 |
| PT65836B (fr) | 1978-07-05 |
| SE418800B (sv) | 1981-06-29 |
| HU175415B (hu) | 1980-07-28 |
| IL50895A0 (en) | 1977-01-31 |
| IL50895A (en) | 1981-01-30 |
| HK3383A (en) | 1983-01-20 |
| MY8400061A (en) | 1984-12-31 |
| US4152435A (en) | 1979-05-01 |
| ZA766791B (en) | 1978-06-28 |
| AU513467B2 (en) | 1980-12-04 |
| IE44751B1 (en) | 1982-03-24 |
| JPS5261233A (en) | 1977-05-20 |
| NL7612423A (nl) | 1977-05-17 |
| CS212780B2 (en) | 1982-03-26 |
| PT65836A (fr) | 1976-12-01 |
| FR2331333B1 (es) | 1978-12-22 |
| AU1959776A (en) | 1978-05-18 |
| SG63282G (en) | 1984-04-19 |
| GB1565686A (en) | 1980-04-23 |
| PH13718A (en) | 1980-09-09 |
| BE848276A (fr) | 1977-05-12 |
| NZ182604A (en) | 1980-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19861222 |