PT77636A - Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives - Google Patents

Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives

Info

Publication number
PT77636A
PT77636A PT77636A PT7763683A PT77636A PT 77636 A PT77636 A PT 77636A PT 77636 A PT77636 A PT 77636A PT 7763683 A PT7763683 A PT 7763683A PT 77636 A PT77636 A PT 77636A
Authority
PT
Portugal
Prior art keywords
modulation
compositions containing
cellular responses
substituted guanine
guanine derivatives
Prior art date
Application number
PT77636A
Other languages
Portuguese (pt)
Other versions
PT77636B (en
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/439,846 external-priority patent/US4539205A/en
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of PT77636A publication Critical patent/PT77636A/en
Publication of PT77636B publication Critical patent/PT77636B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT77636A 1982-11-09 1983-11-09 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives PT77636B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/439,846 US4539205A (en) 1982-11-09 1982-11-09 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US06/546,679 US4643992A (en) 1982-11-09 1983-11-01 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives

Publications (2)

Publication Number Publication Date
PT77636A true PT77636A (en) 1983-12-01
PT77636B PT77636B (en) 1986-03-19

Family

ID=27032191

Family Applications (1)

Application Number Title Priority Date Filing Date
PT77636A PT77636B (en) 1982-11-09 1983-11-09 Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives

Country Status (15)

Country Link
US (1) US4643992A (en)
EP (1) EP0112632B1 (en)
AU (1) AU568325B2 (en)
CA (1) CA1236401A (en)
DE (1) DE3382156D1 (en)
DK (1) DK167898B1 (en)
ES (1) ES527138A0 (en)
FI (1) FI87733C (en)
GR (1) GR78733B (en)
IE (1) IE56701B1 (en)
IL (1) IL70164A (en)
NO (1) NO174215C (en)
NZ (1) NZ206208A (en)
PT (1) PT77636B (en)
WO (1) WO1984001898A1 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476659A (en) * 1982-11-09 1995-12-19 The Scripps Research Institute Cancerous B cell treatment using substituted nucleoside derivatives
US4849411A (en) * 1982-11-09 1989-07-18 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5093318A (en) * 1983-11-01 1992-03-03 Scripps Clinic And Research Foundation Immunostimulating guanosine derivatives and their pharmaceutical compositions
US4900675A (en) * 1983-11-01 1990-02-13 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-β-aldoglycosidyl) derivatives
US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
FR2560212B1 (en) * 1984-02-24 1989-12-29 Unicet MONOCLONAL ANTIBODIES AGAINST INTERFERON A2 AND HYBRIDOMAS PRODUCING SUCH ANTIBODIES
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods
ZA869297B (en) * 1985-12-13 1987-11-25 Scripps Clinic Res Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-beta-aldoglycosidyl)derivatives
US6060459A (en) * 1987-10-28 2000-05-09 Pro-Neuron, Inc. Enhancing blood cell count with oxypurine nucleosides
US4880784A (en) * 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US4902985A (en) * 1988-02-25 1990-02-20 Raytheon Company Microwave reflectiion amplifiers having increased bandwidth
GB2216416B (en) * 1988-03-11 1992-06-24 Sandoz Ltd Nucleobase source for the stimulation of the immune system
WO1989010158A1 (en) * 1988-04-27 1989-11-02 Immunomedics, Inc. Improved radiotherapy
WO1994011003A1 (en) * 1992-11-13 1994-05-26 The Scripps Research Institute Cancerous b cell treatment using substituted nucleoside derivatives
US5441942A (en) * 1994-05-27 1995-08-15 The Scripps Research Institute 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect
US5786359A (en) * 1994-05-27 1998-07-28 The Scripps Research Institute N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US20030100520A1 (en) * 1997-01-21 2003-05-29 Philip Needleman Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination
WO1999057120A1 (en) 1998-05-04 1999-11-11 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
AU4244400A (en) * 1999-04-15 2000-11-02 Board Of Regents, The University Of Texas System Ppgpp and pppgpp as immunomodulatory agents
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
WO2002004448A2 (en) 2000-07-07 2002-01-17 Neotherapeutics, Inc. Methods for treatment of drug-induced peripheral neuropathy and related conditions
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
EP1395262A4 (en) * 2001-06-15 2006-04-12 Ribapharm Corp Nucleoside vaccine adjuvants
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US7351413B2 (en) * 2002-02-21 2008-04-01 Lorantis, Limited Stabilized HBc chimer particles as immunogens for chronic hepatitis
OA13310A (en) 2003-09-05 2007-04-13 Anadys Pharmaceuticals Inc TLR7 ligands for the treatment of hepatitis C.
SI2561872T1 (en) * 2004-12-17 2015-02-27 Anadys Pharmaceuticals, Inc. 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO Š4,5-dĆPYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
CA2630463C (en) 2005-11-21 2015-01-06 Anadys Pharmaceuticals, Inc. Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
ATE496924T1 (en) * 2006-06-22 2011-02-15 Anadys Pharmaceuticals Inc PRODRUGS OF 5-AMINO-3-(3'-DEOXY-BETA-D-RIBOFURANOSYL)-THIAZOLÄ4,5-DÜPYRIMIDINE-2,7-DIONE
WO2008011406A2 (en) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
CA2695399C (en) * 2007-08-02 2017-10-17 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope influenza vaccines
US8637053B2 (en) 2007-12-03 2014-01-28 President And Fellows Of Harvard College Chlamydia antigens
JP2012510289A (en) 2008-12-03 2012-05-10 プロティア ワクチン テクノロジーズ リミテッド Glutamyl tRNA synthetase (GtS) fragment
CN102272134B (en) 2008-12-09 2013-10-16 吉里德科学公司 Modulators of toll-like receptors
WO2011067758A2 (en) 2009-12-02 2011-06-09 Protea Vaccine Technologies Ltd. Immunogenic fragments and multimers from streptococcus pneumoniae proteins
CN103517713A (en) 2011-02-22 2014-01-15 彼昂德瓦克斯医药有限公司 Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
WO2013150518A1 (en) 2012-04-01 2013-10-10 Rappaport Family Institute For Research In The Medical Sciences Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
WO2015151103A1 (en) 2014-04-03 2015-10-08 Biondvax Pharmaceuticals Ltd. Compositions of multimeric-multiepitope influenza polypeptides and their production
MX2017000026A (en) 2014-07-11 2017-05-01 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv.
MX2017003284A (en) 2014-09-16 2017-06-28 Gilead Sciences Inc Solid forms of a toll-like receptor modulator.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174077A (en) * 1967-02-18 1969-12-10 Ajinomoto Kk Process for Preparing 8-Mercaptopurine Derivatives

Also Published As

Publication number Publication date
FI87733B (en) 1992-11-13
NO174215C (en) 1994-03-30
DK334884A (en) 1984-07-06
IL70164A (en) 1988-06-30
ES8601301A1 (en) 1985-11-01
NO174215B (en) 1993-12-20
NO842765L (en) 1984-07-06
WO1984001898A1 (en) 1984-05-24
US4643992A (en) 1987-02-17
FI842748A (en) 1984-07-09
EP0112632A3 (en) 1985-01-23
PT77636B (en) 1986-03-19
FI842748A0 (en) 1984-07-09
IE56701B1 (en) 1991-11-06
GR78733B (en) 1984-10-02
DK334884D0 (en) 1984-07-06
CA1236401A (en) 1988-05-10
ES527138A0 (en) 1985-11-01
DE3382156D1 (en) 1991-03-14
FI87733C (en) 1993-02-25
EP0112632B1 (en) 1991-02-06
EP0112632A2 (en) 1984-07-04
DK167898B1 (en) 1994-01-03
AU2330284A (en) 1984-06-04
AU568325B2 (en) 1987-12-24
IE832605L (en) 1984-05-09
IL70164A0 (en) 1984-02-29
NZ206208A (en) 1987-03-31

Similar Documents

Publication Publication Date Title
EP0112632A3 (en) Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
ZA838365B (en) Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
GB8303882D0 (en) Use of quinoline derivatives
PH17656A (en) Stable monaqueous solution of tetracycline salt
GB8408815D0 (en) Derivatives of azet-2-ones
DE3477568D1 (en) Novel derivatives of guanine
GB8319165D0 (en) Derivatives of morpholinyl daunorubicin
PT73391A (en) Formulations of heterocyclic compounds
GB2121038B (en) Preparation of 6a 10a-trans-hexahydrodibenzopyranones
PH17097A (en) New aniline derivatives
DE2964978D1 (en) Use of benzyl-phenols as antioxidants
GB2083031B (en) Preparation of aminoacetonitrile derivatives
ZA83923B (en) Use of cholecalciferol derivatives
DE3360020D1 (en) Fungicide-active derivatives of benzhydrole
JPS57126450A (en) Synthesis of m-halogen substituted aniline
GB8310144D0 (en) Substituted derivatives of thia-morpholinone
JPS5726651A (en) Manufacture of aniline derivative
EP0108351A3 (en) Use of substituted malonic-acid derivatives as pesticides
JPS57118600A (en) Manufacture of 16alpha-hydroxy-17alpha- aminopregnane derivatives
JPS5571421A (en) Forcing culture of feedstuff
GB2131270B (en) Self-basting of fowls
DE3169710D1 (en) Mixture of dyestuffs
HUT37871A (en) Sinergetic fungicides containing as reagent derivatives of morfoline and alanine
ZA814810B (en) New aniline derivatives
JPS5692861A (en) Carbothio acid derivative of mercaptoacylamino acid