CA1236401A - Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives - Google Patents
Modulation of animal cellular responses with compositions containing 8-substituted guanine derivativesInfo
- Publication number
- CA1236401A CA1236401A CA000440679A CA440679A CA1236401A CA 1236401 A CA1236401 A CA 1236401A CA 000440679 A CA000440679 A CA 000440679A CA 440679 A CA440679 A CA 440679A CA 1236401 A CA1236401 A CA 1236401A
- Authority
- CA
- Canada
- Prior art keywords
- cells
- aldose
- mguo
- antigen
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 235000021313 oleic acid Nutrition 0.000 description 1
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- 239000002245 particle Substances 0.000 description 1
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- 229960001639 penicillamine Drugs 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- 230000004043 responsiveness Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 102220097800 rs876659391 Human genes 0.000 description 1
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- 239000004017 serum-free culture medium Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
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- 235000010487 tragacanth Nutrition 0.000 description 1
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- 230000014616 translation Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US439,846 | 1982-11-09 | ||
| US06/439,846 US4539205A (en) | 1982-11-09 | 1982-11-09 | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US546,679 | 1983-11-01 | ||
| US06/546,679 US4643992A (en) | 1982-11-09 | 1983-11-01 | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1236401A true CA1236401A (en) | 1988-05-10 |
Family
ID=27032191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000440679A Expired CA1236401A (en) | 1982-11-09 | 1983-11-08 | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4643992A (en:Method) |
| EP (1) | EP0112632B1 (en:Method) |
| AU (1) | AU568325B2 (en:Method) |
| CA (1) | CA1236401A (en:Method) |
| DE (1) | DE3382156D1 (en:Method) |
| DK (1) | DK167898B1 (en:Method) |
| ES (1) | ES8601301A1 (en:Method) |
| FI (1) | FI87733C (en:Method) |
| GR (1) | GR78733B (en:Method) |
| IE (1) | IE56701B1 (en:Method) |
| IL (1) | IL70164A (en:Method) |
| NO (1) | NO174215C (en:Method) |
| NZ (1) | NZ206208A (en:Method) |
| PT (1) | PT77636B (en:Method) |
| WO (1) | WO1984001898A1 (en:Method) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849411A (en) * | 1982-11-09 | 1989-07-18 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US5476659A (en) * | 1982-11-09 | 1995-12-19 | The Scripps Research Institute | Cancerous B cell treatment using substituted nucleoside derivatives |
| US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
| US5093318A (en) * | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
| US4900675A (en) * | 1983-11-01 | 1990-02-13 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-β-aldoglycosidyl) derivatives |
| FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
| US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
| ZA869297B (en) * | 1985-12-13 | 1987-11-25 | Scripps Clinic Res | Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-beta-aldoglycosidyl)derivatives |
| US7307166B1 (en) | 1987-10-28 | 2007-12-11 | Wellstat Therapeutics Corporation | Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis |
| US4880784A (en) * | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
| US4902985A (en) * | 1988-02-25 | 1990-02-20 | Raytheon Company | Microwave reflectiion amplifiers having increased bandwidth |
| GB2216416B (en) * | 1988-03-11 | 1992-06-24 | Sandoz Ltd | Nucleobase source for the stimulation of the immune system |
| KR900700156A (ko) * | 1988-04-27 | 1990-08-11 | 원본미기재 | 개선된 방사선 치료법 |
| AU5845594A (en) * | 1992-11-13 | 1994-06-08 | Scripps Research Institute, The | Cancerous b cell treatment using substituted nucleoside derivatives |
| US5441942A (en) * | 1994-05-27 | 1995-08-15 | The Scripps Research Institute | 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect |
| US5786359A (en) * | 1994-05-27 | 1998-07-28 | The Scripps Research Institute | N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines |
| US6338963B1 (en) | 1994-07-25 | 2002-01-15 | Neotherapeutics, Inc. | Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis |
| US20030100520A1 (en) * | 1997-01-21 | 2003-05-29 | Philip Needleman | Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination |
| WO1999057120A1 (en) | 1998-05-04 | 1999-11-11 | Neotherapeutics, Inc. | Novel serotonin-like 9-substituted hypoxanthine and methods of use |
| WO2000062803A2 (en) * | 1999-04-15 | 2000-10-26 | Board Of Regents, The University Of Texas System | ppGpp AND pppGpp AS IMMUNOMODULATORY AGENTS |
| US6288069B1 (en) | 1999-11-16 | 2001-09-11 | Neotherapeutics, Inc. | Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue |
| US6407237B1 (en) | 2001-02-21 | 2002-06-18 | Neotherapeutics, Inc. | Crystal forms of 9-substituted hypoxanthine derivatives |
| US6849735B1 (en) * | 2000-06-23 | 2005-02-01 | Merck Eprova Ag | Methods of synthesis for 9-substituted hypoxanthine derivatives |
| WO2002004448A2 (en) | 2000-07-07 | 2002-01-17 | Neotherapeutics, Inc. | Methods for treatment of drug-induced peripheral neuropathy and related conditions |
| US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US6759427B2 (en) * | 2001-04-20 | 2004-07-06 | Spectrum Pharmaceuticals, Inc. | Synthesis and methods of use of tetrahydroindolone analogues and derivatives |
| WO2002102307A2 (en) * | 2001-06-15 | 2002-12-27 | Ribapharm | Nucleoside vaccine adjuvants |
| US20030055249A1 (en) * | 2001-07-17 | 2003-03-20 | Fick David B. | Synthesis and methods of use of pyrimidine analogues and derivatives |
| US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| WO2005025583A2 (en) * | 2003-09-05 | 2005-03-24 | Anadys Pharmaceuticals, Inc. | Tlr7 ligands for the treatment of hepatitis c |
| ES2459368T3 (es) | 2004-12-17 | 2014-05-09 | Anadys Pharmaceuticals, Inc. | Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos |
| ATE474842T1 (de) | 2005-11-21 | 2010-08-15 | Anadys Pharmaceuticals Inc | Neues verfahren zur herstellung von 5-amino-3h- thiazoloä4,5-düpyrimidin-2-on |
| ATE496924T1 (de) * | 2006-06-22 | 2011-02-15 | Anadys Pharmaceuticals Inc | Prodrugs von 5-amino-3-(3'-deoxy-beta-d- ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion |
| BRPI0714831A2 (pt) | 2006-07-18 | 2013-04-02 | Anadys Pharmaceuticals Inc | composto, composiÇço farmacÊutica e mÉtodos de modulaÇço de atividades imuno da citoquina em paciente, de tratamento de infecÇço de vÍrus c da hepatite em paciente e de desordem relacionada com proliferaÇço em mamÍfero necessitado do mesmo |
| MX2010001284A (es) | 2007-08-02 | 2010-08-31 | Biondvax Pharmaceuticals Ltd | Vacunas contra la influenza con multiepitope multimerico. |
| CA2744739A1 (en) | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
| CA2745205A1 (en) | 2008-12-03 | 2010-06-10 | Protea Vaccine Technologies Ltd. | Glutamyl trna synthetase (gts) fragments |
| PE20120106A1 (es) | 2008-12-09 | 2012-02-20 | Gilead Sciences Inc | Moduladores de receptores tipo toll |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| CA2828068C (en) | 2011-02-22 | 2019-03-19 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| EP3492095A1 (en) | 2012-04-01 | 2019-06-05 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
| CA2944768C (en) | 2014-04-03 | 2022-08-30 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
| KR20190104438A (ko) | 2014-07-11 | 2019-09-09 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 톨-유사 수용체의 조정제 |
| CN106715431A (zh) | 2014-09-16 | 2017-05-24 | 吉利德科学公司 | Toll样受体调节剂的固体形式 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1174077A (en) * | 1967-02-18 | 1969-12-10 | Ajinomoto Kk | Process for Preparing 8-Mercaptopurine Derivatives |
-
1983
- 1983-11-01 US US06/546,679 patent/US4643992A/en not_active Expired - Lifetime
- 1983-11-07 AU AU23302/84A patent/AU568325B2/en not_active Expired
- 1983-11-07 WO PCT/US1983/001722 patent/WO1984001898A1/en not_active Ceased
- 1983-11-08 CA CA000440679A patent/CA1236401A/en not_active Expired
- 1983-11-08 ES ES527138A patent/ES8601301A1/es not_active Expired
- 1983-11-08 IE IE2605/83A patent/IE56701B1/en not_active IP Right Cessation
- 1983-11-08 EP EP83306791A patent/EP0112632B1/en not_active Expired - Lifetime
- 1983-11-08 DE DE8383306791T patent/DE3382156D1/de not_active Expired - Lifetime
- 1983-11-08 IL IL70164A patent/IL70164A/xx not_active IP Right Cessation
- 1983-11-09 NZ NZ206208A patent/NZ206208A/en unknown
- 1983-11-09 GR GR72936A patent/GR78733B/el unknown
- 1983-11-09 PT PT77636A patent/PT77636B/pt unknown
-
1984
- 1984-07-06 NO NO842765A patent/NO174215C/no not_active IP Right Cessation
- 1984-07-06 DK DK334884A patent/DK167898B1/da not_active IP Right Cessation
- 1984-07-09 FI FI842748A patent/FI87733C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK167898B1 (da) | 1994-01-03 |
| EP0112632A3 (en) | 1985-01-23 |
| EP0112632A2 (en) | 1984-07-04 |
| NO174215B (no) | 1993-12-20 |
| DK334884A (da) | 1984-07-06 |
| EP0112632B1 (en) | 1991-02-06 |
| PT77636A (en) | 1983-12-01 |
| IL70164A0 (en) | 1984-02-29 |
| IE56701B1 (en) | 1991-11-06 |
| IL70164A (en) | 1988-06-30 |
| FI87733C (fi) | 1993-02-25 |
| FI87733B (fi) | 1992-11-13 |
| DE3382156D1 (de) | 1991-03-14 |
| NZ206208A (en) | 1987-03-31 |
| ES527138A0 (es) | 1985-11-01 |
| ES8601301A1 (es) | 1985-11-01 |
| NO174215C (no) | 1994-03-30 |
| AU568325B2 (en) | 1987-12-24 |
| DK334884D0 (da) | 1984-07-06 |
| AU2330284A (en) | 1984-06-04 |
| NO842765L (no) | 1984-07-06 |
| PT77636B (en) | 1986-03-19 |
| FI842748L (fi) | 1984-07-09 |
| US4643992A (en) | 1987-02-17 |
| IE832605L (en) | 1984-05-09 |
| FI842748A0 (fi) | 1984-07-09 |
| WO1984001898A1 (en) | 1984-05-24 |
| GR78733B (en:Method) | 1984-10-02 |
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