GR74978B - - Google Patents
Info
- Publication number
- GR74978B GR74978B GR65975A GR810165975A GR74978B GR 74978 B GR74978 B GR 74978B GR 65975 A GR65975 A GR 65975A GR 810165975 A GR810165975 A GR 810165975A GR 74978 B GR74978 B GR 74978B
- Authority
- GR
- Greece
- Prior art keywords
- antihypertonic
- neuroleptic
- compounds
- general formula
- preparation
- Prior art date
Links
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803034001 DE3034001A1 (de) | 1980-09-10 | 1980-09-10 | Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR74978B true GR74978B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-07-12 |
Family
ID=6111554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR65975A GR74978B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-09-10 | 1981-09-08 |
Country Status (20)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| GR79603B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1982-07-24 | 1984-10-31 | Pfizer | |
| DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
| US4544657A (en) * | 1983-05-19 | 1985-10-01 | Hoffmann-La Roche Inc. | Substituted isoquinolines |
| FR2557570B1 (fr) * | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4843077A (en) * | 1987-06-09 | 1989-06-27 | Ortho Pharmaceutical Corporation | Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties |
| US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
| US5332733A (en) * | 1990-11-24 | 1994-07-26 | Kali-Chemie Pharma Gmbh | Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them |
| US6008352A (en) * | 1997-04-03 | 1999-12-28 | Neurogen Corporation | 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands |
| US6313141B1 (en) | 1997-06-13 | 2001-11-06 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
| US5972945A (en) * | 1997-06-13 | 1999-10-26 | Neurogen Corporation | 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands |
| ATE404539T1 (de) * | 1997-10-02 | 2008-08-15 | Eisai R&D Man Co Ltd | Kondensierte pyridinderivate |
| US6040448A (en) | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| CZ299499B6 (cs) * | 1997-10-27 | 2008-08-13 | Neurosearch A/S | Homopiperazinový derivát, farmaceutická kompoziceho obsahující a jeho použití |
| US6613901B2 (en) | 2000-03-08 | 2003-09-02 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
| US20100016293A1 (en) * | 2006-07-03 | 2010-01-21 | Rogier Adriaan Smits | Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use |
| US8623889B2 (en) * | 2010-12-17 | 2014-01-07 | Genentech, Inc. | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof |
| JP7129420B6 (ja) | 2017-03-30 | 2024-02-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｈｐｋ１阻害剤としてのイソキノリン |
| WO2020023560A1 (en) | 2018-07-24 | 2020-01-30 | F. Hoffmann-La Roche Ag | Isoquinoline compounds and uses thereof |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517005A (en) * | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
| GB1244501A (en) * | 1968-03-09 | 1971-09-02 | Aspro Nicholas Ltd | Heterocyclic amines |
| DE2030675A1 (en) * | 1969-06-23 | 1971-02-11 | Arthur D Little, Inc , Cambridge, Mass (V St A) | 3-amino-4-phenyl-isoquinoline derivs |
| US3932412A (en) * | 1970-12-07 | 1976-01-13 | Sandoz, Inc. | 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates |
| DE2503961C3 (de) * | 1975-01-31 | 1980-02-28 | Dr. Karl Thomae Gmbh, 7950 Biberach | Isochinoline |
| DE2420012C3 (de) * | 1974-04-25 | 1980-01-10 | Dr. Karl Thomae Gmbh, 7950 Biberach | Isochinoline |
| AT342057B (de) * | 1974-04-25 | 1978-03-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen |
| DE2811312A1 (de) * | 1978-03-16 | 1979-09-27 | Hoechst Ag | Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln |
| DE2818403A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
| DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
-
1980
- 1980-09-10 DE DE19803034001 patent/DE3034001A1/de not_active Withdrawn
-
1981
- 1981-09-03 EP EP81106884A patent/EP0047923B1/de not_active Expired
- 1981-09-03 AT AT81106884T patent/ATE7389T1/de not_active IP Right Cessation
- 1981-09-03 DE DE8181106884T patent/DE3163510D1/de not_active Expired
- 1981-09-04 ES ES505191A patent/ES505191A0/es active Granted
- 1981-09-07 JP JP56139850A patent/JPS5780372A/ja active Pending
- 1981-09-08 PT PT73629A patent/PT73629B/pt unknown
- 1981-09-08 KR KR1019810003356A patent/KR830007622A/ko not_active Ceased
- 1981-09-08 IL IL63765A patent/IL63765A/xx unknown
- 1981-09-08 GR GR65975A patent/GR74978B/el unknown
- 1981-09-08 FI FI812783A patent/FI71734C/fi not_active IP Right Cessation
- 1981-09-08 NZ NZ198308A patent/NZ198308A/en unknown
- 1981-09-09 CA CA000385547A patent/CA1168232A/en not_active Expired
- 1981-09-09 IE IE2094/81A patent/IE51551B1/en unknown
- 1981-09-09 AU AU75091/81A patent/AU541976B2/en not_active Ceased
- 1981-09-09 ZA ZA816237A patent/ZA816237B/xx unknown
- 1981-09-09 HU HU812595A patent/HU187357B/hu unknown
- 1981-09-09 DK DK400681A patent/DK400681A/da not_active Application Discontinuation
- 1981-09-09 NO NO813066A patent/NO813066L/no unknown
- 1981-10-27 ES ES506583A patent/ES506583A0/es active Granted
- 1981-10-27 ES ES506584A patent/ES506584A0/es active Granted
-
1984
- 1984-02-24 PH PH30299A patent/PH19431A/en unknown
- 1984-03-28 US US06/594,366 patent/US4590273A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO813066L (no) | 1982-03-11 |
| PT73629A (de) | 1981-10-01 |
| IL63765A (en) | 1985-05-31 |
| FI71734B (fi) | 1986-10-31 |
| EP0047923B1 (de) | 1984-05-09 |
| IE812094L (en) | 1982-03-10 |
| FI812783L (fi) | 1982-03-11 |
| AU7509181A (en) | 1982-03-18 |
| HU187357B (en) | 1985-12-28 |
| FI71734C (fi) | 1987-02-09 |
| KR830007622A (ko) | 1983-11-04 |
| ES8304563A1 (es) | 1983-03-01 |
| ZA816237B (en) | 1982-08-25 |
| IE51551B1 (en) | 1987-01-07 |
| ATE7389T1 (de) | 1984-05-15 |
| EP0047923A1 (de) | 1982-03-24 |
| IL63765A0 (en) | 1981-12-31 |
| DE3163510D1 (en) | 1984-06-14 |
| AU541976B2 (en) | 1985-01-31 |
| US4590273A (en) | 1986-05-20 |
| CA1168232A (en) | 1984-05-29 |
| PH19431A (en) | 1986-04-15 |
| ES8206511A1 (es) | 1982-08-16 |
| JPS5780372A (en) | 1982-05-19 |
| NZ198308A (en) | 1984-03-30 |
| ES8305351A1 (es) | 1983-04-01 |
| DE3034001A1 (de) | 1982-04-22 |
| ES506583A0 (es) | 1983-04-01 |
| PT73629B (de) | 1983-04-29 |
| ES505191A0 (es) | 1982-08-16 |
| ES506584A0 (es) | 1983-03-01 |
| DK400681A (da) | 1982-03-11 |
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