GR3030128T3 - Methods for inhibiting bone loss with 3,4-diarylchroman - Google Patents

Methods for inhibiting bone loss with 3,4-diarylchroman

Info

Publication number
GR3030128T3
GR3030128T3 GR990401210T GR990401210T GR3030128T3 GR 3030128 T3 GR3030128 T3 GR 3030128T3 GR 990401210 T GR990401210 T GR 990401210T GR 990401210 T GR990401210 T GR 990401210T GR 3030128 T3 GR3030128 T3 GR 3030128T3
Authority
GR
Greece
Prior art keywords
bone loss
diarylchroman
methods
inhibiting bone
phenyl
Prior art date
Application number
GR990401210T
Other languages
English (en)
Inventor
Virender M Labroo
James R Piggott
Steven D Bain
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of GR3030128T3 publication Critical patent/GR3030128T3/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pens And Brushes (AREA)
  • Confectionery (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GR990401210T 1993-03-11 1999-04-30 Methods for inhibiting bone loss with 3,4-diarylchroman GR3030128T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/029,729 US5280040A (en) 1993-03-11 1993-03-11 Methods for reducing bone loss using centchroman derivatives
PCT/US1994/000633 WO1994020098A1 (en) 1993-03-11 1994-01-13 Methods for inhibiting bone loss with 3,4-diarylchroman

Publications (1)

Publication Number Publication Date
GR3030128T3 true GR3030128T3 (en) 1999-07-30

Family

ID=21850559

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401210T GR3030128T3 (en) 1993-03-11 1999-04-30 Methods for inhibiting bone loss with 3,4-diarylchroman

Country Status (19)

Country Link
US (2) US5280040A (el)
EP (1) EP0688214B1 (el)
JP (1) JP2834581B2 (el)
KR (1) KR100263009B1 (el)
AT (1) ATE178488T1 (el)
AU (2) AU674394B2 (el)
BR (1) BR9405843A (el)
CA (1) CA2157879C (el)
CZ (1) CZ287603B6 (el)
DE (1) DE69417733T2 (el)
DK (1) DK0688214T3 (el)
ES (1) ES2131678T3 (el)
GR (1) GR3030128T3 (el)
HU (1) HUT74575A (el)
NO (1) NO309361B1 (el)
NZ (1) NZ262569A (el)
RU (1) RU2166940C2 (el)
SG (1) SG65584A1 (el)
WO (1) WO1994020098A1 (el)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5389646A (en) * 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
US5637598A (en) * 1994-11-18 1997-06-10 Eli Lilly And Company Methods of inhibiting bone loss
BR9606754A (pt) * 1995-01-13 1998-01-06 Novo Nordisk As Uso de compostos processo para tratamento e profilaxia de ginecomastia idiopática ou fisiológia e novo detalhe característico ou combinação de detalhes
JPH10512269A (ja) * 1995-01-20 1998-11-24 ノボ ノルディスク アクティーゼルスカブ 大脳の変性疾患の治療または予防用の医薬組成物の製造のための3,4−ジフェニルクロマンの使用
TW448046B (en) * 1995-01-20 2001-08-01 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity
EP0804188A1 (en) * 1995-01-20 1997-11-05 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for vasodilatory treatment or prophylaxis
US20030083733A1 (en) * 1997-10-10 2003-05-01 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US20020091433A1 (en) * 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
HUP9802319A3 (en) * 1995-10-23 1999-12-28 Zymogenetics Inc Seattle Pharmaceutical compositions for treatment of bone deficit conditions
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US5883118A (en) * 1996-01-11 1999-03-16 Nova Nordisk A/S Prostatic carcinoma
US5859045A (en) * 1996-05-08 1999-01-12 Novo Nordisk A/S Novo Alle Crystalline -! 3R 4R-trans-7 methoxy 2,2-dimethyl1-3-phenyl 1-4 4-12 pyrrolidin-1 -Y1!ethoxyl 1!chromane hydrogen fumarate
KR20000010644A (ko) * 1996-05-08 2000-02-25 한센 핀 베네드, 안네 제헤르 결정성 (-)-3r,4r-트랜스-7-메톡시-2,2-디메틸-3-페닐-4-{4-[2-(피롤리딘-1-일)에톡시]페닐}크로만, 푸마르산수소염
US5756539A (en) * 1996-07-11 1998-05-26 Novo Nordis A/S 3, 4-diphenyl chromans for inhibiting one or more psychiatric disorders
US5780502A (en) * 1996-07-12 1998-07-14 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome
US5922753A (en) * 1996-10-23 1999-07-13 Zymogenetics, Inc. Methods for treating bone deficit conditions with benzothiazole
US5990169A (en) * 1996-10-23 1999-11-23 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6017940A (en) * 1996-10-23 2000-01-25 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6153631A (en) * 1996-10-23 2000-11-28 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5919808A (en) * 1996-10-23 1999-07-06 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5939444A (en) * 1996-10-23 1999-08-17 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
US5948776A (en) * 1996-10-23 1999-09-07 Zymogenetic, Inc. Compositions and methods for treating bone deficit conditions
US6251901B1 (en) 1996-10-23 2001-06-26 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US5965573A (en) * 1996-10-23 1999-10-12 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
WO1998017267A1 (en) * 1996-10-23 1998-04-30 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
US6342514B1 (en) 1996-10-23 2002-01-29 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
DK0937060T3 (da) * 1996-10-28 2003-04-07 Novo Nordisk As Nye cis-3,4-chroman-derivater, der er nyttige i forebyggelsen eller behandlingen af østrogen-relaterede sygdomme eller syndromer
ATE231141T1 (de) * 1996-10-28 2003-02-15 Novo Nordisk As (-)-enantiomere von cis-3,4-chromanderivaten zur vorbeugung oder behandlungvon oestrogenbezogenen krankheiten oder syndromen
JP2001502710A (ja) * 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連疾患または症候群の予防または治療に有用な新規なシス―3,4―クロマン誘導体
ZA979644B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US5994390A (en) * 1996-10-28 1999-11-30 Novo Nordisk Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6316494B1 (en) 1996-10-28 2001-11-13 Novo Nordisk A/S cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5919817A (en) * 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5958967A (en) * 1996-10-28 1999-09-28 Novo Nordisk A/S Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
WO1998018772A1 (en) * 1996-10-28 1998-05-07 Novo Nordisk A/S NOVEL cis-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES
AU4700097A (en) * 1996-10-28 1998-05-22 Novo Nordisk A/S Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6043269A (en) * 1996-10-28 2000-03-28 Novo Nordisk A/S cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979643B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
ZA979650B (en) * 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US5985306A (en) * 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
IL129617A0 (en) * 1996-10-28 2000-02-29 Novo Nordisk As Novel CIS-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5977158A (en) * 1996-11-28 1999-11-02 Novo Nordisk A/S Pharmaceutical formulations comprising levormeloxifene compounds
EP0959880A1 (en) * 1996-11-28 1999-12-01 Novo Nordisk A/S Pharmaceutical formulation
DE69734832T2 (de) * 1996-12-13 2006-08-31 Zymogenetics, Inc., Seattle Zusammensetzungen und verfahren zum stimulieren von knochenwachstum
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6080779A (en) * 1996-12-13 2000-06-27 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
ZA981558B (en) * 1997-02-27 1998-08-27 Novo Nordisk As Inclusion complexes in aqueous solution
US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6372776B2 (en) * 1997-06-12 2002-04-16 Novo Nordisk A/S Crystalline(−)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen maleate
US6649631B1 (en) 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
ZA989763B (en) * 1997-11-07 1999-05-07 Novo Nordisk As Pharmaceutical composition comprising levormeloxifene in low dose
EP1028724A1 (en) * 1997-11-10 2000-08-23 Novo Nordisk A/S Transdermal delivery of 3,4-diarylchromans
US6838436B1 (en) 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6462019B1 (en) 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6525084B2 (en) * 1998-07-23 2003-02-25 Novo Nordisk A/S Stable pharmaceutical formulation
US7214706B2 (en) 2000-03-01 2007-05-08 Akzo Nobel N.V. Chroman derivatives as estrogenic compounds
ES2236056T3 (es) * 2001-01-24 2005-07-16 Chiesi Farmaceutici S.P.A. Derivados de 2h-1-benzopirano, procedimientos para su preparacion y composiciones farmaceuticas de los mismos.
EP1281710A1 (en) * 2001-08-03 2003-02-05 CHIESI FARMACEUTICI S.p.A. 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
AU2002237282B2 (en) * 2001-01-24 2007-02-15 Chiesi Farmaceutici S.P.A. 2H-1-Benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
US6613083B2 (en) * 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US20030181374A1 (en) * 2002-01-14 2003-09-25 Mundy Gregory R. Methods and compositions for stimulating bone growth using inhibitors of microtubule assembly
AU2003231255A1 (en) * 2002-05-02 2003-12-31 Osteoscreen, Inc. Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate)
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
US20040254238A1 (en) * 2003-04-07 2004-12-16 Osteoscreen Bone growth stimulation with NO/statin and other NO modulating combinations
MX2007003216A (es) 2004-09-21 2008-03-10 Novogen Res Pty Ltd Derivados y medicamentos sustituidos del cromano y su uso en terapias.
US8080675B2 (en) * 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
EP2217260B1 (en) * 2007-12-04 2016-11-09 Ben-Gurion University Of The Negev Research And Development Authority Amphiphilic peptide matrices for treatment of osteoporosis
US9663484B2 (en) 2010-11-01 2017-05-30 Mei Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US9701655B2 (en) 2014-02-07 2017-07-11 Novogen Limited Functionalised benzopyran compounds and use thereof
PT3253208T (pt) 2015-02-02 2021-06-17 The Spanish National Cancer Res Centre Terapêuticas de combinação para utilização no tratamento do cancro da mama
LU100182B1 (en) 2017-04-06 2018-10-15 Univ Hamburg Eppendorf Uke Therapeutic use of microRNA 19A/19B

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) * 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
US3822287A (en) * 1969-04-17 1974-07-02 Rexall Drug Chemical Process for preparation of substituted 3,4-(diphenyl)chromans
US4210644A (en) * 1978-02-23 1980-07-01 The Johns Hopkins University Male contraception
US4447622A (en) * 1981-09-22 1984-05-08 Council Of Scientific And Industrial Research Rafi Marg Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
JPS6054379A (ja) * 1983-09-05 1985-03-28 Takeda Chem Ind Ltd 新規4h−1−ベンゾピラン−4−オン誘導体,その製法および用途
US4644012A (en) * 1983-12-21 1987-02-17 Takeda Chemical Industries, Ltd. Treatment for osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
JPS63310825A (ja) * 1987-06-03 1988-12-19 フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ 医薬に有用な二環式化合物のn−イミダゾリル誘導体
US5015661A (en) * 1988-08-09 1991-05-14 Hoffmann-La Roche Inc. Chromanes and their pharmaceutical compositions and methods
US5063234A (en) * 1990-05-25 1991-11-05 Eli Lilly And Company Method of inhibiting demineralization of bone
JP3502403B2 (ja) * 1991-12-16 2004-03-02 アベンティス ファーマ株式会社 骨吸収抑制剤
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives

Also Published As

Publication number Publication date
CZ232095A3 (en) 1996-04-17
JP2834581B2 (ja) 1998-12-09
ES2131678T3 (es) 1999-08-01
AU674394B2 (en) 1996-12-19
NO953542D0 (no) 1995-09-08
NO953542L (no) 1995-09-08
ATE178488T1 (de) 1999-04-15
NO309361B1 (no) 2001-01-22
WO1994020098A1 (en) 1994-09-15
EP0688214A1 (en) 1995-12-27
CA2157879A1 (en) 1994-09-12
KR960700708A (ko) 1996-02-24
DE69417733D1 (de) 1999-05-12
AU695497B2 (en) 1998-08-13
CZ287603B6 (en) 2001-01-17
US5464862A (en) 1995-11-07
DK0688214T3 (da) 2000-10-09
AU6230294A (en) 1994-09-26
AU1639497A (en) 1997-05-22
RU2166940C2 (ru) 2001-05-20
KR100263009B1 (ko) 2000-08-01
EP0688214B1 (en) 1999-04-07
HU9502624D0 (en) 1995-11-28
CA2157879C (en) 2000-08-29
US5280040A (en) 1994-01-18
NZ262569A (en) 1997-08-22
DE69417733T2 (de) 1999-09-16
JPH08506346A (ja) 1996-07-09
SG65584A1 (en) 1999-06-22
HUT74575A (en) 1997-01-28
BR9405843A (pt) 1996-01-16

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