GR3022037T3 - Process for producing preserved medicaments containing human proteins for the purposes of infusion or injection. - Google Patents

Process for producing preserved medicaments containing human proteins for the purposes of infusion or injection.

Info

Publication number
GR3022037T3
GR3022037T3 GR960403464T GR960403464T GR3022037T3 GR 3022037 T3 GR3022037 T3 GR 3022037T3 GR 960403464 T GR960403464 T GR 960403464T GR 960403464 T GR960403464 T GR 960403464T GR 3022037 T3 GR3022037 T3 GR 3022037T3
Authority
GR
Greece
Prior art keywords
preservative
prepn
infusion
injection
human protein
Prior art date
Application number
GR960403464T
Other languages
English (en)
Inventor
Heinrich Woog
Werner Gruber
Hans-Joerg Markl
Gerhard Winter
Fritz Demmer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6438353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3022037(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of GR3022037T3 publication Critical patent/GR3022037T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
GR960403464T 1991-08-15 1996-12-13 Process for producing preserved medicaments containing human proteins for the purposes of infusion or injection. GR3022037T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4126983A DE4126983A1 (de) 1991-08-15 1991-08-15 Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
PCT/EP1992/001822 WO1993003744A1 (de) 1991-08-15 1992-08-10 Verfahren zur herstellung von humanproteinhaltigen, konservierten arzneimitteln für infusions- oder injektionszwecke

Publications (1)

Publication Number Publication Date
GR3022037T3 true GR3022037T3 (en) 1997-03-31

Family

ID=6438353

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960403464T GR3022037T3 (en) 1991-08-15 1996-12-13 Process for producing preserved medicaments containing human proteins for the purposes of infusion or injection.

Country Status (25)

Country Link
US (2) US5503827A (el)
EP (2) EP0607156B1 (el)
JP (1) JP3670660B2 (el)
KR (1) KR100263282B1 (el)
AT (1) ATE145138T1 (el)
AU (2) AU678756B2 (el)
CA (1) CA2115348C (el)
CZ (1) CZ284853B6 (el)
DE (2) DE4126983A1 (el)
DK (1) DK0607156T3 (el)
ES (1) ES2094923T3 (el)
FI (1) FI112169B (el)
GE (1) GEP19981289B (el)
GR (1) GR3022037T3 (el)
HU (1) HU227421B1 (el)
IL (1) IL102775A (el)
MX (1) MX9204636A (el)
NO (1) NO309844B1 (el)
RU (1) RU2091068C1 (el)
SG (1) SG66226A1 (el)
SK (1) SK281910B6 (el)
TW (1) TW351677B (el)
UA (1) UA26343C2 (el)
WO (1) WO1993003744A1 (el)
ZA (1) ZA926122B (el)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
DE4242919A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
SE9300105D0 (sv) * 1993-01-15 1993-01-15 Kabi Pharmacia Ab Stable protein solution
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
JP3541054B2 (ja) * 1994-04-21 2004-07-07 ユニ・チャーム株式会社 使い捨ておむつ
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
DK0837883T3 (da) * 1995-06-07 2005-12-19 Chiron Corp Fremgangsmåde til oplösning, oprensning og genfoldning af protein
US5888968A (en) * 1995-06-07 1999-03-30 Chiron Corporation TFPI formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
JP2000504318A (ja) * 1996-01-19 2000-04-11 イーライ・リリー・アンド・カンパニー 肥満症タンパク質製剤
WO1997026004A1 (en) * 1996-01-19 1997-07-24 Eli Lilly And Company Obesity protein formulations
TWI240627B (en) * 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
US7312196B2 (en) * 1997-01-08 2007-12-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US6410511B2 (en) * 1997-01-08 2002-06-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
DE19716154A1 (de) * 1997-04-18 1998-10-22 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsform für Peptide, Proteine und Nukleinsäuren
DK0917879T3 (da) * 1997-11-22 2002-11-04 Roche Diagnostics Gmbh Forbedret fremgangsmåde til stabilisering af proteiner
JP2001525341A (ja) * 1997-11-28 2001-12-11 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性ヘッジホッグタンパク質変異体、その調製方法及び医薬への適用
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物
WO1999044630A1 (fr) * 1998-03-06 1999-09-10 Chugai Seiyaku Kabushiki Kaisha Preparations exemptes de proteines
US20050203187A1 (en) * 1998-06-01 2005-09-15 Verbiscar Anthony J. Formulations useful for the treatment of varicella zoster virus infections and methods for the use thereof
US6207718B1 (en) 1998-08-07 2001-03-27 Ontogeny, Inc. Pharmaceutical compositions containing hedgehog protein
US6979442B1 (en) * 1998-08-17 2005-12-27 Pfizer Inc. Stabilized protein compositions
AU775041B2 (en) * 1999-04-09 2004-07-15 Ortho-Mcneil Pharmaceutical, Inc. Pharmaceutical compositions of erythropoietin
WO2001007075A2 (en) * 1999-07-22 2001-02-01 Aventis Pharmaceuticals, Inc. Multi-dose erythropoietin formulations
US7109161B1 (en) 1999-07-22 2006-09-19 Aventis Pharmaceuticals, Inc. Preserved pharmaceutical formulations
ES2220673T3 (es) 2000-02-29 2004-12-16 Pfizer Products Inc. Factor estimulante de colonias de granulocitos estabilizado.
US20020141970A1 (en) * 2001-03-05 2002-10-03 Pettit Dean K. Stable aqueous solutions of granulocyte macrophage colony-stimulating factor
US6818613B2 (en) * 2001-11-07 2004-11-16 Ortho-Mcneil Pharmaceutical, Inc. Aqueous sustained-release formulations of proteins
CN100411683C (zh) * 2002-05-21 2008-08-20 阿斯比奥制药株式会社 含有生长素释放肽的药物组合物
SI21257A (sl) * 2002-07-17 2004-02-29 LEK farmacevtska dru�ba d.d. Stabilni farmacevtski pripravek, ki vsebuje eritropoietin
US7812120B2 (en) * 2003-03-21 2010-10-12 Par Pharmaceutical, Inc. Nasal calcitonin formulations containing chlorobutanol
AU2003901515A0 (en) * 2003-04-02 2003-04-17 Norika Holdings Sterilisation process for pharmaceutical product
ES2385888T3 (es) * 2003-06-10 2012-08-02 Lg Life Sciences Ltd. Solución acuosa estable de eritropoyetina humana que no contiene albúmina sérica
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
ATE516306T1 (de) * 2003-08-13 2011-07-15 Novartis Vaccines & Diagnostic Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen
EP1532983A1 (en) * 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
WO2006022301A1 (ja) * 2004-08-24 2006-03-02 Daiichi Asubio Pharma Co., Ltd. 生理活性ペプチド液状製剤
AU2006295340B2 (en) * 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
DE202006020194U1 (de) 2006-03-01 2007-12-06 Bioceuticals Arzneimittel Ag G-CSF-Flüssigformulierung
CN101795670A (zh) 2007-08-27 2010-08-04 百奥杰诺瑞克斯股份有限公司 G-csf的液体制剂
UA98001C2 (uk) * 2007-08-27 2012-04-10 Биодженерикс Аг Рідка лікарська форма кон'югата полімер-g-csf
WO2009064838A1 (en) 2007-11-15 2009-05-22 Amgen, Inc. Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration
UA99337C2 (ru) * 2008-02-08 2012-08-10 Биодженерикс Аг Жидкая лекарственная форма фсг
US8120369B2 (en) 2009-03-02 2012-02-21 Harris Corporation Dielectric characterization of bituminous froth
CA2772220A1 (en) * 2009-09-25 2011-03-31 Santen Pharmaceutical Co. Ltd. Eye drops
JP6078344B2 (ja) 2010-02-04 2017-02-08 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト 免疫グロブリン製剤
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
EP3607074A4 (en) * 2017-04-05 2021-07-07 Modernatx, Inc. REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY
EP3773492A4 (en) * 2018-04-09 2022-01-05 Board of Regents, The University of Texas System THERAPEUTIC TARGETING OF ONCOGENS USING EXOSOMES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3106073A1 (de) * 1981-02-19 1982-08-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von sterilen zubereitungen hochviskoser loesungen und substanzen
GB2177914B (en) * 1985-06-04 1989-10-25 Chugai Pharmaceutical Co Ltd A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia
DE3729863A1 (de) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
JP3485184B2 (ja) * 1989-07-14 2004-01-13 アメリカン サイアナミド カンパニー インターロイキン含有安定ワクチン組成物
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
US5661125A (en) 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions

Also Published As

Publication number Publication date
IL102775A (en) 1999-12-22
HU9400416D0 (en) 1994-05-30
FI112169B (fi) 2003-11-14
CA2115348A1 (en) 1993-03-04
US6303113B1 (en) 2001-10-16
NO940499L (no) 1994-02-14
AU678756B2 (en) 1997-06-12
SK281910B6 (sk) 2001-09-11
EP0607156A1 (de) 1994-07-27
EP0528313A1 (de) 1993-02-24
NO309844B1 (no) 2001-04-09
UA26343C2 (uk) 1999-08-30
HUT67379A (en) 1995-04-28
HU227421B1 (en) 2011-05-30
RU2091068C1 (ru) 1997-09-27
NO940499D0 (no) 1994-02-14
DK0607156T3 (da) 1997-04-07
TW351677B (en) 1999-02-01
WO1993003744A1 (de) 1993-03-04
US5503827A (en) 1996-04-02
DE4126983A1 (de) 1993-02-18
RU94016163A (ru) 1996-08-10
ES2094923T3 (es) 1997-02-01
GEP19981289B (en) 1998-05-01
KR100263282B1 (ko) 2000-08-01
CA2115348C (en) 2007-07-17
AU710768B2 (en) 1999-09-30
CZ28794A3 (en) 1994-08-17
SK14894A3 (en) 1994-11-09
DE59207523D1 (de) 1996-12-19
EP0607156B1 (de) 1996-11-13
ZA926122B (en) 1994-02-14
JPH06510031A (ja) 1994-11-10
SG66226A1 (en) 1999-07-20
JP3670660B2 (ja) 2005-07-13
FI940674A (fi) 1994-02-14
FI940674A0 (fi) 1994-02-14
AU2409492A (en) 1993-03-16
IL102775A0 (en) 1993-01-31
CZ284853B6 (cs) 1999-03-17
DE59207523C5 (de) 2006-11-16
ATE145138T1 (de) 1996-11-15
AU1633997A (en) 1997-05-22
MX9204636A (es) 1993-02-01

Similar Documents

Publication Publication Date Title
GR3022037T3 (en) Process for producing preserved medicaments containing human proteins for the purposes of infusion or injection.
CS274681B2 (en) Method of erythropoietin's stabilized preparation production
EP0299756A3 (en) Anti-acne composition
DE69329367T2 (de) Wachstumshormon-enthaltendeproteinformulierung
EP0747092A3 (en) Dissolution liquid for drug in iontophoresis
ES445542A1 (es) Procedimiento de obtencion de laminas de recubrimiento para aplicaciones cosmeticas.
JPS5762218A (en) Ophthalmic solution
IE38514L (en) Insulin preparations.
IT1243742B (it) Composizioni farmaceutiche a base di calcitonine
PT82277A (en) Method for enhancement of absorption of proteins with medicinal properties
CA2153787A1 (en) Solution containing igf-1
IT1206281B (it) Attivatore del plasminogeno dei tessuti e suo impiego nella medicina umana ed in veterinaria