GR3020395T3 - Hexa-cyclic compound - Google Patents
Hexa-cyclic compoundInfo
- Publication number
- GR3020395T3 GR3020395T3 GR960401767T GR960401767T GR3020395T3 GR 3020395 T3 GR3020395 T3 GR 3020395T3 GR 960401767 T GR960401767 T GR 960401767T GR 960401767 T GR960401767 T GR 960401767T GR 3020395 T3 GR3020395 T3 GR 3020395T3
- Authority
- GR
- Greece
- Prior art keywords
- compound
- hexa
- cyclic compound
- antitumour
- abundantly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Liquid Crystal Substances (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1581291 | 1991-01-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3020395T3 true GR3020395T3 (en) | 1996-09-30 |
Family
ID=11899258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR960401767T GR3020395T3 (en) | 1991-01-16 | 1996-06-28 | Hexa-cyclic compound |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0495432B1 (el) |
JP (1) | JP3008226B2 (el) |
KR (1) | KR100191193B1 (el) |
AT (1) | ATE138661T1 (el) |
AU (1) | AU640549B2 (el) |
CA (1) | CA2059305C (el) |
DE (1) | DE69211023T2 (el) |
DK (1) | DK0495432T3 (el) |
ES (1) | ES2090366T3 (el) |
FI (1) | FI103047B1 (el) |
GR (1) | GR3020395T3 (el) |
HK (1) | HK1001561A1 (el) |
IE (1) | IE920079A1 (el) |
NO (1) | NO180448C (el) |
RU (1) | RU2071476C1 (el) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6407115B1 (en) * | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
US5658920A (en) * | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
ES2187634T3 (es) * | 1995-02-22 | 2003-06-16 | Daiichi Seiyaku Co | Derivados de aminotetralona y su procedimiento de produccion. |
US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
IN189180B (el) | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
AR030207A1 (es) * | 2000-04-07 | 2003-08-13 | Daiichi Seiyaku Co | Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma |
EP1295864B1 (en) * | 2001-05-08 | 2008-12-03 | Mitsui Chemicals Polyurethanes, Inc. | Process for preparation of 1,5-diaminonaphthalenes |
IL162058A0 (en) | 2001-11-30 | 2005-11-20 | Chugai Pharmaceutical Co Ltd | Hexacyclic compounds |
KR100501439B1 (ko) * | 2002-09-27 | 2005-07-18 | 현대자동차주식회사 | 차량 충돌시 연료 누출 방지장치 |
EP1599484A2 (en) * | 2003-02-21 | 2005-11-30 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic camptothecin derivatives |
CA2563502A1 (en) | 2004-04-09 | 2005-10-20 | Chugai Seiyaku Kabushiki Kaisha | Novel water-soluble prodrug |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
ITMI20061475A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
BRPI0922508A8 (pt) | 2008-12-23 | 2016-01-19 | Pharmasset Inc | Análogos de nucleosídeo |
CA2748057C (en) | 2008-12-23 | 2018-07-03 | Pharmasset, Inc. | Nucleoside phosphoramidates |
JP5793084B2 (ja) | 2008-12-23 | 2015-10-14 | ギリアド ファーマセット エルエルシー | プリンヌクレオシドの合成 |
CN102858790A (zh) | 2010-03-31 | 2013-01-02 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
EP3632471A1 (en) | 2012-10-11 | 2020-04-08 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
EP2910573B1 (en) | 2012-10-19 | 2020-02-19 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
KR102535900B1 (ko) | 2013-12-25 | 2023-05-26 | 다이이찌 산쿄 가부시키가이샤 | 항 trop2 항체-약물 컨쥬게이트 |
SG10201800210TA (en) | 2014-01-31 | 2018-02-27 | Daiichi Sankyo Co Ltd | Anti-her2 antibody-drug conjugate |
ES2754348T3 (es) | 2014-04-10 | 2020-04-17 | Daiichi Sankyo Co Ltd | Conjugado de (anticuerpo anti-HER2)-fármaco |
KR102127623B1 (ko) | 2014-04-10 | 2020-06-29 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
EP4180455A1 (en) | 2015-06-29 | 2023-05-17 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
AU2017341000A1 (en) | 2016-10-07 | 2019-04-11 | Daiichi Sankyo Company, Limited | Therapy for drug-resistant cancer by administration of anti-HER2 antibody/drug conjugate |
AU2017377233A1 (en) | 2016-12-12 | 2019-06-13 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
AU2018210081A1 (en) | 2017-01-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate |
TW202330036A (zh) | 2017-05-15 | 2023-08-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
CN117838880A (zh) * | 2017-08-31 | 2024-04-09 | 第一三共株式会社 | 制备抗体-药物缀合物的新方法 |
SG11202000997YA (en) | 2017-08-31 | 2020-03-30 | Daiichi Sankyo Co Ltd | Improved method for producing antibody-drug conjugate |
DK3794042T3 (da) | 2018-05-18 | 2024-04-15 | Daiichi Sankyo Co Ltd | Anti-muc1-exatecet-antistof-lægemiddelkonjugat |
ES2930295T3 (es) * | 2019-03-29 | 2022-12-09 | Medimmune Ltd | Compuestos y conjugados de los mismos |
KR20220130749A (ko) * | 2020-01-22 | 2022-09-27 | 메디뮨 리미티드 | 화합물 및 이의 접합체 |
TW202140076A (zh) * | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
CN111470998B (zh) * | 2020-06-28 | 2020-09-25 | 上海皓元生物医药科技有限公司 | 用于合成喜树碱衍生物的中间体及其制备方法和用途 |
JP2023552610A (ja) * | 2020-12-11 | 2023-12-18 | ウィゲン・バイオメディシン・テクノロジー・(シャンハイ)・カンパニー・リミテッド | 新規カンプトテシン誘導体、それを含む組成物およびその使用 |
EP4289851A1 (en) * | 2021-02-05 | 2023-12-13 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor, and application thereof |
WO2022171115A1 (zh) * | 2021-02-09 | 2022-08-18 | 微境生物医药科技(上海)有限公司 | 用于adc制备的喜树碱衍生物 |
WO2023020531A1 (zh) * | 2021-08-17 | 2023-02-23 | 江苏迈威康新药研发有限公司 | 5,8-二氨基-3,4-二氢-2h-1-萘酮的合成方法以及其中采用的中间体化合物 |
CN115724758A (zh) * | 2021-08-24 | 2023-03-03 | 杭州中美华东制药有限公司 | 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法 |
WO2023072143A1 (zh) * | 2021-10-26 | 2023-05-04 | 上海弼领生物技术有限公司 | 一种喜树碱类衍生物中间体、其制备方法和用途 |
WO2023083919A1 (en) | 2021-11-09 | 2023-05-19 | Tubulis Gmbh | Conjugates comprising a phosphorus (v) and a camptothecin moiety |
US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
WO2023109965A1 (zh) * | 2021-12-16 | 2023-06-22 | 迈威(上海)生物科技股份有限公司 | 一种喜树碱类化合物及其偶联物 |
WO2024020536A1 (en) * | 2022-07-22 | 2024-01-25 | Nj Bio, Inc. | Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells |
US20240116945A1 (en) * | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
WO2024083926A1 (en) | 2022-10-18 | 2024-04-25 | Tubulis Gmbh | Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof |
WO2024083953A1 (en) | 2022-10-18 | 2024-04-25 | Tubulis Gmbh | Novel anti-tpbg antibody and antibody-drug-conjugates based thereon, therapeutic methods and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
-
1991
- 1991-12-04 JP JP03320688A patent/JP3008226B2/ja not_active Expired - Fee Related
-
1992
- 1992-01-10 IE IE007992A patent/IE920079A1/en not_active IP Right Cessation
- 1992-01-13 AT AT92100449T patent/ATE138661T1/de not_active IP Right Cessation
- 1992-01-13 DK DK92100449.5T patent/DK0495432T3/da active
- 1992-01-13 KR KR1019920000352A patent/KR100191193B1/ko not_active IP Right Cessation
- 1992-01-13 DE DE69211023T patent/DE69211023T2/de not_active Expired - Fee Related
- 1992-01-13 EP EP92100449A patent/EP0495432B1/en not_active Expired - Lifetime
- 1992-01-13 ES ES92100449T patent/ES2090366T3/es not_active Expired - Lifetime
- 1992-01-14 AU AU10185/92A patent/AU640549B2/en not_active Ceased
- 1992-01-14 CA CA002059305A patent/CA2059305C/en not_active Expired - Fee Related
- 1992-01-15 NO NO920201A patent/NO180448C/no unknown
- 1992-01-15 RU SU925010678A patent/RU2071476C1/ru not_active IP Right Cessation
- 1992-01-16 FI FI920194A patent/FI103047B1/fi not_active IP Right Cessation
-
1996
- 1996-06-28 GR GR960401767T patent/GR3020395T3/el unknown
-
1998
- 1998-01-21 HK HK98100529A patent/HK1001561A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3008226B2 (ja) | 2000-02-14 |
FI103047B (fi) | 1999-04-15 |
AU640549B2 (en) | 1993-08-26 |
HK1001561A1 (en) | 1998-06-26 |
CA2059305C (en) | 2001-07-31 |
NO180448B (no) | 1997-01-13 |
FI920194A (fi) | 1992-07-17 |
DE69211023D1 (de) | 1996-07-04 |
NO920201L (no) | 1992-07-17 |
AU1018592A (en) | 1992-07-23 |
ES2090366T3 (es) | 1996-10-16 |
DE69211023T2 (de) | 1997-01-09 |
RU2071476C1 (ru) | 1997-01-10 |
ATE138661T1 (de) | 1996-06-15 |
NO180448C (no) | 1997-04-23 |
DK0495432T3 (da) | 1996-10-21 |
CA2059305A1 (en) | 1992-07-17 |
FI103047B1 (fi) | 1999-04-15 |
JPH0559061A (ja) | 1993-03-09 |
KR100191193B1 (ko) | 1999-06-15 |
NO920201D0 (no) | 1992-01-15 |
EP0495432B1 (en) | 1996-05-29 |
KR920014816A (ko) | 1992-08-25 |
IE920079A1 (en) | 1992-07-29 |
EP0495432A1 (en) | 1992-07-22 |
FI920194A0 (fi) | 1992-01-16 |
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