NO180448C - Heksacyklisk forbindelse - Google Patents
Heksacyklisk forbindelseInfo
- Publication number
- NO180448C NO180448C NO920201A NO920201A NO180448C NO 180448 C NO180448 C NO 180448C NO 920201 A NO920201 A NO 920201A NO 920201 A NO920201 A NO 920201A NO 180448 C NO180448 C NO 180448C
- Authority
- NO
- Norway
- Prior art keywords
- compound
- antitumour
- hexacyclic compound
- abundantly
- camptothecin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fats And Perfumes (AREA)
- Lubricants (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Liquid Crystal Substances (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1581291 | 1991-01-16 |
Publications (4)
Publication Number | Publication Date |
---|---|
NO920201D0 NO920201D0 (no) | 1992-01-15 |
NO920201L NO920201L (no) | 1992-07-17 |
NO180448B NO180448B (no) | 1997-01-13 |
NO180448C true NO180448C (no) | 1997-04-23 |
Family
ID=11899258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO920201A NO180448C (no) | 1991-01-16 | 1992-01-15 | Heksacyklisk forbindelse |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0495432B1 (no) |
JP (1) | JP3008226B2 (no) |
KR (1) | KR100191193B1 (no) |
AT (1) | ATE138661T1 (no) |
AU (1) | AU640549B2 (no) |
CA (1) | CA2059305C (no) |
DE (1) | DE69211023T2 (no) |
DK (1) | DK0495432T3 (no) |
ES (1) | ES2090366T3 (no) |
FI (1) | FI103047B1 (no) |
GR (1) | GR3020395T3 (no) |
HK (1) | HK1001561A1 (no) |
IE (1) | IE920079A1 (no) |
NO (1) | NO180448C (no) |
RU (1) | RU2071476C1 (no) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5637770A (en) * | 1991-01-16 | 1997-06-10 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
US6407115B1 (en) * | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
PT811603E (pt) * | 1995-02-22 | 2003-03-31 | Daiichi Seiyaku Co | Derivados da aminotetralona e processo para a producao dos mesmos |
US6504029B1 (en) * | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
IN189180B (no) | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
AR030207A1 (es) * | 2000-04-07 | 2003-08-13 | Daiichi Seiyaku Co | Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma |
DE60230097D1 (de) * | 2001-05-08 | 2009-01-15 | Mitsui Chemicals Polyurethanes | Verfahren zur herstellung von 1,5-diaminonaphthalinen |
RU2299212C2 (ru) | 2001-11-30 | 2007-05-20 | Чугаи Сейяку Кабусики Кайся | Гексациклические соединения, фармацевтическая композиция, содержащая их и их применение в качестве противоопухолевых средств, способ получения гексациклических соединений |
KR100501439B1 (ko) * | 2002-09-27 | 2005-07-18 | 현대자동차주식회사 | 차량 충돌시 연료 누출 방지장치 |
CN1777611A (zh) * | 2003-02-21 | 2006-05-24 | 中外制药株式会社 | 制备六环喜树碱衍生物的方法 |
CN1964979B (zh) | 2004-04-09 | 2011-07-27 | 中外制药株式会社 | 新颖的水溶性前药 |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
ITMI20061475A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
CL2009002206A1 (es) | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
EA201100851A1 (ru) | 2008-12-23 | 2012-04-30 | Фармассет, Инк. | Аналоги нуклеозидов |
BR112012024884A2 (pt) | 2010-03-31 | 2016-10-18 | Gilead Pharmasset Llc | síntese estereosseletiva de ativos contendo fósforo |
KR102584005B1 (ko) | 2012-10-11 | 2023-09-27 | 다이이찌 산쿄 가부시키가이샤 | 글리신아미드 화합물의 제조 방법 |
JP6272230B2 (ja) | 2012-10-19 | 2018-01-31 | 第一三共株式会社 | 親水性構造を含むリンカーで結合させた抗体−薬物コンジュゲート |
RU2743077C2 (ru) | 2013-12-25 | 2021-02-15 | Дайити Санкио Компани, Лимитед | Конъюгат анти-trop2 антитело-лекарственное средство |
CN105829346B (zh) | 2014-01-31 | 2019-08-23 | 第一三共株式会社 | 抗her2抗体-药物偶联物 |
ES2859648T3 (es) | 2014-04-10 | 2021-10-04 | Daiichi Sankyo Co Ltd | Conjugado anticuerpo-fármaco anti-HER3 |
WO2015155976A1 (ja) | 2014-04-10 | 2015-10-15 | 第一三共株式会社 | 抗her2抗体-薬物コンジュゲート |
ES2938186T3 (es) | 2015-06-29 | 2023-04-05 | Daiichi Sankyo Co Ltd | Procedimiento de fabricación selectiva de un conjugado anticuerpo-fármaco |
US20190330368A1 (en) | 2016-10-07 | 2019-10-31 | Daiichi Sankyo Company, Limited | Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate |
CA3046293A1 (en) | 2016-12-12 | 2018-06-21 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
EP3572428A4 (en) | 2017-01-17 | 2020-12-30 | Daiichi Sankyo Company, Limited | ANTI-GPR20 ANTIBODY AND ANTI-GPR20 ANTIBODY MEDICINAL CONJUGATE |
TW202330036A (zh) | 2017-05-15 | 2023-08-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
WO2019044947A1 (ja) | 2017-08-31 | 2019-03-07 | 第一三共株式会社 | 抗体-薬物コンジュゲートの改良製造方法 |
CN117838881A (zh) | 2017-08-31 | 2024-04-09 | 第一三共株式会社 | 制备抗体-药物缀合物的新方法 |
EP4257611A3 (en) | 2018-05-18 | 2024-03-06 | Glycotope GmbH | Anti-muc1 antibody |
PT3946464T (pt) | 2019-03-29 | 2022-11-16 | Medimmune Ltd | Compostos e seus conjugados |
TW202140076A (zh) * | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
MX2022009052A (es) * | 2020-01-22 | 2022-08-15 | Medimmune Ltd | Compuestos y conjugados de estos. |
CN111470998B (zh) * | 2020-06-28 | 2020-09-25 | 上海皓元生物医药科技有限公司 | 用于合成喜树碱衍生物的中间体及其制备方法和用途 |
CN116583526A (zh) * | 2020-12-11 | 2023-08-11 | 微境生物医药科技(上海)有限公司 | 新型喜树碱衍生物、含其的组合物和其用途 |
EP4289851A1 (en) * | 2021-02-05 | 2023-12-13 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor, and application thereof |
CN116888123A (zh) * | 2021-02-09 | 2023-10-13 | 微境生物医药科技(上海)有限公司 | 用于adc制备的喜树碱衍生物 |
WO2023020531A1 (zh) * | 2021-08-17 | 2023-02-23 | 江苏迈威康新药研发有限公司 | 5,8-二氨基-3,4-二氢-2h-1-萘酮的合成方法以及其中采用的中间体化合物 |
CN115724758A (zh) * | 2021-08-24 | 2023-03-03 | 杭州中美华东制药有限公司 | 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法 |
CN118119594A (zh) * | 2021-10-26 | 2024-05-31 | 上海弼领生物技术有限公司 | 一种喜树碱类衍生物中间体、其制备方法和用途 |
CA3237379A1 (en) | 2021-11-09 | 2023-05-19 | Marc-Andre Kasper | Conjugates comprising a phosphorus (v) and a camptothecin moiety |
US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
TW202334238A (zh) | 2021-11-30 | 2023-09-01 | 日商第一三共股份有限公司 | 蛋白酶分解性遮蔽抗體 |
CA3241157A1 (en) * | 2021-12-16 | 2023-06-22 | Wei Zhou | Camptothecin compound and conjugate thereof |
WO2024020536A1 (en) * | 2022-07-22 | 2024-01-25 | Nj Bio, Inc. | Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells |
US20240116945A1 (en) * | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
US20240190958A1 (en) | 2022-10-18 | 2024-06-13 | Tubulis Gmbh | Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof |
WO2024083953A1 (en) | 2022-10-18 | 2024-04-25 | Tubulis Gmbh | Novel anti-tpbg antibody and antibody-drug-conjugates based thereon, therapeutic methods and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
-
1991
- 1991-12-04 JP JP03320688A patent/JP3008226B2/ja not_active Expired - Fee Related
-
1992
- 1992-01-10 IE IE007992A patent/IE920079A1/en not_active IP Right Cessation
- 1992-01-13 DK DK92100449.5T patent/DK0495432T3/da active
- 1992-01-13 DE DE69211023T patent/DE69211023T2/de not_active Expired - Fee Related
- 1992-01-13 KR KR1019920000352A patent/KR100191193B1/ko not_active IP Right Cessation
- 1992-01-13 EP EP92100449A patent/EP0495432B1/en not_active Expired - Lifetime
- 1992-01-13 ES ES92100449T patent/ES2090366T3/es not_active Expired - Lifetime
- 1992-01-13 AT AT92100449T patent/ATE138661T1/de not_active IP Right Cessation
- 1992-01-14 CA CA002059305A patent/CA2059305C/en not_active Expired - Fee Related
- 1992-01-14 AU AU10185/92A patent/AU640549B2/en not_active Ceased
- 1992-01-15 RU SU925010678A patent/RU2071476C1/ru not_active IP Right Cessation
- 1992-01-15 NO NO920201A patent/NO180448C/no unknown
- 1992-01-16 FI FI920194A patent/FI103047B1/fi not_active IP Right Cessation
-
1996
- 1996-06-28 GR GR960401767T patent/GR3020395T3/el unknown
-
1998
- 1998-01-21 HK HK98100529A patent/HK1001561A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI103047B (fi) | 1999-04-15 |
EP0495432B1 (en) | 1996-05-29 |
NO180448B (no) | 1997-01-13 |
EP0495432A1 (en) | 1992-07-22 |
ATE138661T1 (de) | 1996-06-15 |
NO920201L (no) | 1992-07-17 |
DE69211023T2 (de) | 1997-01-09 |
KR100191193B1 (ko) | 1999-06-15 |
ES2090366T3 (es) | 1996-10-16 |
AU640549B2 (en) | 1993-08-26 |
DE69211023D1 (de) | 1996-07-04 |
FI920194A0 (fi) | 1992-01-16 |
RU2071476C1 (ru) | 1997-01-10 |
NO920201D0 (no) | 1992-01-15 |
AU1018592A (en) | 1992-07-23 |
JP3008226B2 (ja) | 2000-02-14 |
GR3020395T3 (en) | 1996-09-30 |
FI103047B1 (fi) | 1999-04-15 |
HK1001561A1 (en) | 1998-06-26 |
KR920014816A (ko) | 1992-08-25 |
FI920194A (fi) | 1992-07-17 |
IE920079A1 (en) | 1992-07-29 |
CA2059305C (en) | 2001-07-31 |
CA2059305A1 (en) | 1992-07-17 |
DK0495432T3 (da) | 1996-10-21 |
JPH0559061A (ja) | 1993-03-09 |
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