ES2187634T3 - Derivados de aminotetralona y su procedimiento de produccion. - Google Patents

Derivados de aminotetralona y su procedimiento de produccion.

Info

Publication number
ES2187634T3
ES2187634T3 ES96903202T ES96903202T ES2187634T3 ES 2187634 T3 ES2187634 T3 ES 2187634T3 ES 96903202 T ES96903202 T ES 96903202T ES 96903202 T ES96903202 T ES 96903202T ES 2187634 T3 ES2187634 T3 ES 2187634T3
Authority
ES
Spain
Prior art keywords
aminotetralona
derivatives
production procedure
preparation
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96903202T
Other languages
English (en)
Inventor
Shinji Daiichi Pharma Kamihara
Kazuaki Daiichi Pharmace Kanai
Shigeru Daiichi Pharma Noguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2187634T3 publication Critical patent/ES2187634T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE UN COMPUESTO (4) MEDIANTE LA RUTA DE REACCION DESCRITA A CONTINUACION: EN LA QUE R{SUP,1} Y R{SUP,2} CADA UNO REPRESENTAN H, HALOGENO, OH O UN GRUPO ALQUILO C{SUB,1-6}; X E Y CADA UNO REPRESENTAN UN GRUPO AMINO PROTEGIDO Y N SIGNIFICA DE 0 A 4. DE CONFORMIDAD CON EL PROCESO DESCRITO, PUEDE OBTENERSE DE UNA FORMA CONVENIENTE Y CON UN ELEVADO RENDIMIENTO UN DERIVADO AMINOTETRALONA QUE ES UN INTERMEDIARIO UTIL PARA LA PREPARACION INDUSTRIAL DE UN DERIVADO DE CAMPTOTECINA.
ES96903202T 1995-02-22 1996-02-21 Derivados de aminotetralona y su procedimiento de produccion. Expired - Lifetime ES2187634T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3337695 1995-02-22

Publications (1)

Publication Number Publication Date
ES2187634T3 true ES2187634T3 (es) 2003-06-16

Family

ID=12384880

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96903202T Expired - Lifetime ES2187634T3 (es) 1995-02-22 1996-02-21 Derivados de aminotetralona y su procedimiento de produccion.

Country Status (14)

Country Link
US (1) US5849945A (es)
EP (1) EP0811603B1 (es)
KR (1) KR100406020B1 (es)
CN (1) CN1104409C (es)
AT (1) ATE227703T1 (es)
CA (1) CA2213201A1 (es)
DE (1) DE69624796T2 (es)
DK (1) DK0811603T3 (es)
EA (1) EA000122B1 (es)
ES (1) ES2187634T3 (es)
FI (1) FI973434A (es)
NO (1) NO973842L (es)
PT (1) PT811603E (es)
WO (1) WO1996026181A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011109464A1 (en) 2010-03-02 2011-09-09 Concert Pharmaceuticals Inc. Deuterated tetrahydronaphthalene derivatives
US8575361B2 (en) 2010-03-02 2013-11-05 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
SG11202001514XA (en) 2017-08-31 2020-03-30 Daiichi Sankyo Co Ltd Novel method for producing antibody-drug conjugate
PT3946464T (pt) 2019-03-29 2022-11-16 Medimmune Ltd Compostos e seus conjugados
CN114516808B (zh) * 2020-11-20 2024-01-19 华东师范大学 一种氨基保护的苯并环酮类化合物的制备方法
CN115703712A (zh) * 2021-08-17 2023-02-17 江苏迈威康新药研发有限公司 5,8-二氨基-3,4-二氢-2h-1-萘酮的合成方法以及其中采用的中间体化合物
CN115724758A (zh) * 2021-08-24 2023-03-03 杭州中美华东制药有限公司 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法
WO2023072143A1 (zh) * 2021-10-26 2023-05-04 上海弼领生物技术有限公司 一种喜树碱类衍生物中间体、其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US5637770A (en) * 1991-01-16 1997-06-10 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤

Also Published As

Publication number Publication date
CN1175943A (zh) 1998-03-11
DE69624796T2 (de) 2003-04-03
EA000122B1 (ru) 1998-08-27
CN1104409C (zh) 2003-04-02
ATE227703T1 (de) 2002-11-15
CA2213201A1 (en) 1996-08-29
EP0811603A1 (en) 1997-12-10
FI973434A0 (fi) 1997-08-21
NO973842D0 (no) 1997-08-21
DE69624796D1 (de) 2002-12-19
NO973842L (no) 1997-08-21
EP0811603A4 (en) 1998-10-07
PT811603E (pt) 2003-03-31
KR19980702346A (ko) 1998-07-15
WO1996026181A1 (fr) 1996-08-29
KR100406020B1 (ko) 2004-03-20
DK0811603T3 (da) 2002-12-16
EA199700189A1 (ru) 1998-02-26
FI973434A (fi) 1997-08-21
US5849945A (en) 1998-12-15
EP0811603B1 (en) 2002-11-13

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