EA199700189A1 - Производные аминотетралона и способ их получения - Google Patents

Производные аминотетралона и способ их получения

Info

Publication number
EA199700189A1
EA199700189A1 EA199700189A EA199700189A EA199700189A1 EA 199700189 A1 EA199700189 A1 EA 199700189A1 EA 199700189 A EA199700189 A EA 199700189A EA 199700189 A EA199700189 A EA 199700189A EA 199700189 A1 EA199700189 A1 EA 199700189A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminothetralone
derivatives
production
preparation
derivative
Prior art date
Application number
EA199700189A
Other languages
English (en)
Other versions
EA000122B1 (ru
Inventor
Синдзи Камихара
Казуаки Канаи
Сигеру Ногути
Original Assignee
Дайити Фармасьютикал Ко., Лтд.
Кабусики Кайся Якульт Хонса
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Фармасьютикал Ко., Лтд., Кабусики Кайся Якульт Хонса filed Critical Дайити Фармасьютикал Ко., Лтд.
Publication of EA199700189A1 publication Critical patent/EA199700189A1/ru
Publication of EA000122B1 publication Critical patent/EA000122B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В соответствии с настоящим изобретением предлагается способ получения соединения (4) по представленной ниже схеме реакцийгде Rи R, каждый представляет H, галоген, OH или C-алкильную группу, X и Y, представляет каждый защищенную аминогруппу и n представляет 0-4. Описанным выше способом можно подходящим образом и с высоким выходом получить производное аминотетралона, которое является промежуточным соединением, пригодным для промышленного получения производного камптотецина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700189A 1995-02-22 1996-02-21 Способ получения замещенных производных бензола EA000122B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3337695 1995-02-22
PCT/JP1996/000390 WO1996026181A1 (fr) 1995-02-22 1996-02-21 Derives d'aminotetralone et leurs procede de production

Publications (2)

Publication Number Publication Date
EA199700189A1 true EA199700189A1 (ru) 1998-02-26
EA000122B1 EA000122B1 (ru) 1998-08-27

Family

ID=12384880

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700189A EA000122B1 (ru) 1995-02-22 1996-02-21 Способ получения замещенных производных бензола

Country Status (14)

Country Link
US (1) US5849945A (ru)
EP (1) EP0811603B1 (ru)
KR (1) KR100406020B1 (ru)
CN (1) CN1104409C (ru)
AT (1) ATE227703T1 (ru)
CA (1) CA2213201A1 (ru)
DE (1) DE69624796T2 (ru)
DK (1) DK0811603T3 (ru)
EA (1) EA000122B1 (ru)
ES (1) ES2187634T3 (ru)
FI (1) FI973434A (ru)
NO (1) NO973842D0 (ru)
PT (1) PT811603E (ru)
WO (1) WO1996026181A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575361B2 (en) 2010-03-02 2013-11-05 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
EP2542534A1 (en) 2010-03-02 2013-01-09 Concert Pharmaceuticals Inc. Deuterated tetrahydronaphthalene derivatives
US11318212B2 (en) 2017-08-31 2022-05-03 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
JP7210770B2 (ja) 2019-03-29 2023-01-23 メドイミューン・リミテッド 化合物及びその複合体
CN114516808B (zh) * 2020-11-20 2024-01-19 华东师范大学 一种氨基保护的苯并环酮类化合物的制备方法
CN115703712A (zh) * 2021-08-17 2023-02-17 江苏迈威康新药研发有限公司 5,8-二氨基-3,4-二氢-2h-1-萘酮的合成方法以及其中采用的中间体化合物
CN115724758A (zh) * 2021-08-24 2023-03-03 杭州中美华东制药有限公司 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法
WO2023072143A1 (zh) * 2021-10-26 2023-05-04 上海弼领生物技术有限公司 一种喜树碱类衍生物中间体、其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
US5658920A (en) * 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤

Also Published As

Publication number Publication date
DE69624796T2 (de) 2003-04-03
ATE227703T1 (de) 2002-11-15
NO973842L (no) 1997-08-21
KR100406020B1 (ko) 2004-03-20
ES2187634T3 (es) 2003-06-16
FI973434A0 (fi) 1997-08-21
DE69624796D1 (de) 2002-12-19
CA2213201A1 (en) 1996-08-29
CN1104409C (zh) 2003-04-02
NO973842D0 (no) 1997-08-21
US5849945A (en) 1998-12-15
WO1996026181A1 (fr) 1996-08-29
CN1175943A (zh) 1998-03-11
KR19980702346A (ko) 1998-07-15
EA000122B1 (ru) 1998-08-27
PT811603E (pt) 2003-03-31
EP0811603A4 (en) 1998-10-07
EP0811603B1 (en) 2002-11-13
DK0811603T3 (da) 2002-12-16
FI973434A (fi) 1997-08-21
EP0811603A1 (en) 1997-12-10

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KZ KG MD TJ TM RU