EA199700189A1 - Производные аминотетралона и способ их получения - Google Patents
Производные аминотетралона и способ их полученияInfo
- Publication number
- EA199700189A1 EA199700189A1 EA199700189A EA199700189A EA199700189A1 EA 199700189 A1 EA199700189 A1 EA 199700189A1 EA 199700189 A EA199700189 A EA 199700189A EA 199700189 A EA199700189 A EA 199700189A EA 199700189 A1 EA199700189 A1 EA 199700189A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aminothetralone
- derivatives
- production
- preparation
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В соответствии с настоящим изобретением предлагается способ получения соединения (4) по представленной ниже схеме реакцийгде Rи R, каждый представляет H, галоген, OH или C-алкильную группу, X и Y, представляет каждый защищенную аминогруппу и n представляет 0-4. Описанным выше способом можно подходящим образом и с высоким выходом получить производное аминотетралона, которое является промежуточным соединением, пригодным для промышленного получения производного камптотецина.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3337695 | 1995-02-22 | ||
PCT/JP1996/000390 WO1996026181A1 (fr) | 1995-02-22 | 1996-02-21 | Derives d'aminotetralone et leurs procede de production |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199700189A1 true EA199700189A1 (ru) | 1998-02-26 |
EA000122B1 EA000122B1 (ru) | 1998-08-27 |
Family
ID=12384880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199700189A EA000122B1 (ru) | 1995-02-22 | 1996-02-21 | Способ получения замещенных производных бензола |
Country Status (14)
Country | Link |
---|---|
US (1) | US5849945A (ru) |
EP (1) | EP0811603B1 (ru) |
KR (1) | KR100406020B1 (ru) |
CN (1) | CN1104409C (ru) |
AT (1) | ATE227703T1 (ru) |
CA (1) | CA2213201A1 (ru) |
DE (1) | DE69624796T2 (ru) |
DK (1) | DK0811603T3 (ru) |
EA (1) | EA000122B1 (ru) |
ES (1) | ES2187634T3 (ru) |
FI (1) | FI973434A0 (ru) |
NO (1) | NO973842D0 (ru) |
PT (1) | PT811603E (ru) |
WO (1) | WO1996026181A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3144296A1 (en) | 2010-03-02 | 2017-03-22 | Concert Pharmaceuticals, Inc. | Deuterated tetrahydronaphthalene derivatives |
US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
CN117865839A (zh) | 2017-08-31 | 2024-04-12 | 第一三共株式会社 | 制备抗体-药物缀合物的新方法 |
DK3946464T3 (da) | 2019-03-29 | 2022-10-31 | Medimmune Ltd | Forbindelser og konjugater deraf |
CN114516808B (zh) * | 2020-11-20 | 2024-01-19 | 华东师范大学 | 一种氨基保护的苯并环酮类化合物的制备方法 |
EP4389732A1 (en) * | 2021-08-17 | 2024-06-26 | Jiangsu Mabwell Health Pharmaceutical R&D Co., Ltd. | Method for synthesizing 5,8-diamino-3,4-dihydro-2h-1-naphthalenone and intermediate compound used therein |
CN115724758A (zh) * | 2021-08-24 | 2023-03-03 | 杭州中美华东制药有限公司 | 喜树碱衍生物中间体及其合成方法和利用中间体合成喜树碱衍生物的方法 |
CN118119594A (zh) * | 2021-10-26 | 2024-05-31 | 上海弼领生物技术有限公司 | 一种喜树碱类衍生物中间体、其制备方法和用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
US5637770A (en) * | 1991-01-16 | 1997-06-10 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
JP3359955B2 (ja) * | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
-
1996
- 1996-02-21 PT PT96903202T patent/PT811603E/pt unknown
- 1996-02-21 WO PCT/JP1996/000390 patent/WO1996026181A1/ja active IP Right Grant
- 1996-02-21 CN CN96192090A patent/CN1104409C/zh not_active Expired - Fee Related
- 1996-02-21 US US08/894,230 patent/US5849945A/en not_active Expired - Fee Related
- 1996-02-21 AT AT96903202T patent/ATE227703T1/de not_active IP Right Cessation
- 1996-02-21 CA CA002213201A patent/CA2213201A1/en not_active Abandoned
- 1996-02-21 DK DK96903202T patent/DK0811603T3/da active
- 1996-02-21 EA EA199700189A patent/EA000122B1/ru not_active IP Right Cessation
- 1996-02-21 ES ES96903202T patent/ES2187634T3/es not_active Expired - Lifetime
- 1996-02-21 KR KR1019970705743A patent/KR100406020B1/ko not_active IP Right Cessation
- 1996-02-21 DE DE69624796T patent/DE69624796T2/de not_active Expired - Fee Related
- 1996-02-21 EP EP96903202A patent/EP0811603B1/en not_active Expired - Lifetime
-
1997
- 1997-08-21 FI FI973434A patent/FI973434A0/fi unknown
- 1997-08-21 NO NO973842A patent/NO973842D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE227703T1 (de) | 2002-11-15 |
US5849945A (en) | 1998-12-15 |
KR100406020B1 (ko) | 2004-03-20 |
CN1175943A (zh) | 1998-03-11 |
DK0811603T3 (da) | 2002-12-16 |
PT811603E (pt) | 2003-03-31 |
EA000122B1 (ru) | 1998-08-27 |
EP0811603B1 (en) | 2002-11-13 |
EP0811603A4 (en) | 1998-10-07 |
DE69624796T2 (de) | 2003-04-03 |
DE69624796D1 (de) | 2002-12-19 |
CA2213201A1 (en) | 1996-08-29 |
CN1104409C (zh) | 2003-04-02 |
ES2187634T3 (es) | 2003-06-16 |
NO973842L (no) | 1997-08-21 |
WO1996026181A1 (fr) | 1996-08-29 |
NO973842D0 (no) | 1997-08-21 |
FI973434A (fi) | 1997-08-21 |
KR19980702346A (ko) | 1998-07-15 |
EP0811603A1 (en) | 1997-12-10 |
FI973434A0 (fi) | 1997-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO303574B1 (no) | Ny fremgangsmÕte for fremstilling av 9-amino-6-demetyl-6-deoksytetracykliner | |
ES2188661T3 (es) | Preparacion de un derivado de camptothecin por ciclacion intramolecular. | |
HUT48583A (en) | Process for production of derivatives of substituated indolinon | |
EA199700189A1 (ru) | Производные аминотетралона и способ их получения | |
EP0897911A4 (en) | METHOD FOR PRODUCING CYSTEIN DERIVATIVES | |
CA2263268A1 (en) | Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers | |
CA2200604A1 (en) | Novel production intermediate and process for producing pyridine derivative | |
CA2245080A1 (en) | Process for the preparation of heteroarylcarboxylic amides and esters | |
EP1132375A4 (en) | AMINOACRYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | |
AU1735397A (en) | Pyridonecarboxylic acid derivatives and intermediates for the synthesis thereo | |
ATE329917T1 (de) | 1h-pyrrolo 1,2-bö 1,2,4ötriazolederivate, zwischenprodukte und verfahren zur herstellung von 1h-1,2,4,-triazol-5-yl essigsäureesterderivate | |
CA2307979A1 (en) | Novel production intermediate and process for producing pyridine derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ BY KZ KG MD TJ TM RU |