GR3006802T3 - - Google Patents

Info

Publication number
GR3006802T3
GR3006802T3 GR930400057T GR930400057T GR3006802T3 GR 3006802 T3 GR3006802 T3 GR 3006802T3 GR 930400057 T GR930400057 T GR 930400057T GR 930400057 T GR930400057 T GR 930400057T GR 3006802 T3 GR3006802 T3 GR 3006802T3
Authority
GR
Greece
Application number
GR930400057T
Other languages
Greek (el)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3006802T3 publication Critical patent/GR3006802T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
GR930400057T 1986-06-13 1993-01-14 GR3006802T3 (instruction)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13
AT0269187A AT398425B (de) 1986-06-13 1987-10-12 Neue tricyclische lactame

Publications (1)

Publication Number Publication Date
GR3006802T3 true GR3006802T3 (instruction) 1993-06-30

Family

ID=25598925

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930400057T GR3006802T3 (instruction) 1986-06-13 1993-01-14

Country Status (12)

Country Link
EP (1) EP0249223B1 (instruction)
JP (1) JP2542213B2 (instruction)
KR (1) KR950014572B1 (instruction)
AR (1) AR247213A1 (instruction)
AT (1) AT398425B (instruction)
AU (1) AU601433B2 (instruction)
CA (1) CA1337654C (instruction)
DK (1) DK170840B1 (instruction)
ES (1) ES2044870T3 (instruction)
GR (1) GR3006802T3 (instruction)
IE (1) IE61476B1 (instruction)
ZA (1) ZA874107B (instruction)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
ES2108027T3 (es) * 1990-12-21 1997-12-16 Merrell Pharma Inc Nuevos compuestos triciclicos que contienen amino y nitro, utiles como inhibidores de ace.
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
ES2106112T3 (es) * 1991-09-27 1997-11-01 Merrell Pharma Inc Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace.
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
WO1993023403A1 (en) * 1992-05-15 1993-11-25 Merrell Dow Pharmaceuticals Inc. NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
ATE197714T1 (de) * 1992-10-30 2000-12-15 Merrell Pharma Inc Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace- hemmer
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
ATE161251T1 (de) * 1993-11-19 1998-01-15 Merrell Pharma Inc Neues verfahren zur herstellung von (s)-1-(2(s)- (1,3-dihydro-1,3-dioxoisoindol-2-yl)-1-oxo-3- phenylpropyl>-1,2,3,4-tetrahydropyridin-2- carbonsäuremethylester und dessen zwischenprodukte
CN1100785C (zh) * 1994-02-14 2003-02-05 默里尔药物公司 1,3,4,5－四氢苯并[c]氮杂䓬－3－酮二硫化物衍生物及方法
FI963167A7 (fi) * 1994-02-14 1996-08-13 Merrell Pharma Inc Enkefalinaasin ja ACE:n ihibiittoreina käyttökelpoisia uusia 2-substit uoituja indaani-2-merkaptoasetyyliamididisulfidijohdannaisia
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
ATE209205T1 (de) * 1994-02-14 2001-12-15 Merrell Pharma Inc Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
AU687507B2 (en) * 1994-02-14 1998-02-26 Merrell Pharmaceuticals Inc. Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) * 1994-03-24 1995-09-28 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
HUP9774624A2 (en) * 1994-03-24 1997-01-28 Merrell Pharma Inc Hypocholesterolemic, antiatheroclerotic and hypotriglyceridemic condensed benzazepine mercaptoacetylamide disulfide derivatives
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
CA2297134C (en) * 1994-12-21 2004-02-10 Hoechst Marion Roussel, Inc. A novel process for preparing intermediates or inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AR247213A1 (es) 1994-11-30
DK300487A (da) 1987-12-14
CA1337654C (en) 1995-11-28
EP0249223B1 (en) 1992-10-14
EP0249223A3 (en) 1989-01-25
AU7402287A (en) 1987-12-17
IE61476B1 (en) 1994-11-02
DK300487D0 (da) 1987-06-12
IE871547L (en) 1987-12-13
JP2542213B2 (ja) 1996-10-09
EP0249223A2 (en) 1987-12-16
KR950014572B1 (ko) 1995-12-08
AT398425B (de) 1994-12-27
DK170840B1 (da) 1996-02-05
ATA269187A (de) 1994-04-15
AU601433B2 (en) 1990-09-13
ES2044870T3 (es) 1994-01-16
ZA874107B (instruction) 1987-12-09
JPS62298591A (ja) 1987-12-25
KR880000399A (ko) 1988-03-25

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