GR3006211T3 - - Google Patents

Info

Publication number
GR3006211T3
GR3006211T3 GR920402021T GR920402021T GR3006211T3 GR 3006211 T3 GR3006211 T3 GR 3006211T3 GR 920402021 T GR920402021 T GR 920402021T GR 920402021 T GR920402021 T GR 920402021T GR 3006211 T3 GR3006211 T3 GR 3006211T3
Authority
GR
Greece
Prior art keywords
drug
conjugate
monoclonal antibody
antitumor drug
antibody conjugate
Prior art date
Application number
GR920402021T
Other languages
Greek (el)
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3006211T3 publication Critical patent/GR3006211T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
GR920402021T 1987-11-23 1992-11-12 GR3006211T3 (cg-RX-API-DMAC7.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/124,313 US4952394A (en) 1987-11-23 1987-11-23 Drug-monoclonal antibody conjugates

Publications (1)

Publication Number Publication Date
GR3006211T3 true GR3006211T3 (cg-RX-API-DMAC7.html) 1993-06-21

Family

ID=22414122

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920402021T GR3006211T3 (cg-RX-API-DMAC7.html) 1987-11-23 1992-11-12

Country Status (16)

Country Link
US (1) US4952394A (cg-RX-API-DMAC7.html)
EP (1) EP0317957B1 (cg-RX-API-DMAC7.html)
JP (1) JPH02111731A (cg-RX-API-DMAC7.html)
KR (1) KR910005887B1 (cg-RX-API-DMAC7.html)
AT (1) ATE81986T1 (cg-RX-API-DMAC7.html)
AU (1) AU617380B2 (cg-RX-API-DMAC7.html)
CA (1) CA1303524C (cg-RX-API-DMAC7.html)
DE (1) DE3875700T2 (cg-RX-API-DMAC7.html)
DK (1) DK651088A (cg-RX-API-DMAC7.html)
FI (1) FI885361A7 (cg-RX-API-DMAC7.html)
GR (1) GR3006211T3 (cg-RX-API-DMAC7.html)
IL (1) IL88428A0 (cg-RX-API-DMAC7.html)
NO (1) NO169958C (cg-RX-API-DMAC7.html)
NZ (1) NZ226955A (cg-RX-API-DMAC7.html)
PT (1) PT89062B (cg-RX-API-DMAC7.html)
ZA (1) ZA886811B (cg-RX-API-DMAC7.html)

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IL146055A0 (en) * 1999-04-23 2002-07-25 Alza Corp Conjugate having a cleavable linkage for use in a liposome
US7303760B2 (en) 1999-04-23 2007-12-04 Alza Corporation Method for treating multi-drug resistant tumors
US7238368B2 (en) 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
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AU2001250898A1 (en) * 2000-03-17 2001-10-03 The Salk Institute For Biological Studies Compositions associated with complex formation
US6610504B1 (en) 2000-04-10 2003-08-26 General Atomics Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
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CN100406065C (zh) 2000-12-01 2008-07-30 细胞工厂治疗公司 糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
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US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7087600B2 (en) * 2001-05-31 2006-08-08 Medarex, Inc. Peptidyl prodrugs and linkers and stabilizers useful therefor
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US7384760B2 (en) * 2004-04-30 2008-06-10 General Atomics Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase
JP4806680B2 (ja) * 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
RU2402548C2 (ru) * 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
US7541330B2 (en) * 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
MX2007002210A (es) * 2004-08-26 2007-05-07 Nicholas Piramal India Ltd Profarmacos que contienen enlazantes bioescindibles novedosos.
DK1851250T3 (da) * 2005-02-18 2012-07-09 Medarex Inc Humant monoklonalt antistof mod prostataspecifikt membranantigen (psma)
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
NZ566982A (en) * 2005-09-26 2011-06-30 Medarex Inc Duocarmycin drug conjugates
EP1940789B1 (en) 2005-10-26 2011-11-23 Medarex, Inc. Methods and compounds for preparing cc-1065 analogs
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
CN101711284A (zh) 2007-01-25 2010-05-19 达娜-法勃肿瘤研究所 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
AU2008218766A1 (en) * 2007-02-21 2008-08-28 Medarex, Inc. Chemical linkers with single amino acids and conjugates thereof
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EP2190861A4 (en) 2007-08-22 2011-03-30 Univ California ACTIVE BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION AND USE
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US8445637B2 (en) 2008-12-05 2013-05-21 Abraxis Bioscience, Llc SPARC binding peptides and uses thereof
BRPI1006141B8 (pt) 2009-01-12 2021-05-25 Cytomx Therapeutics Llc composições de anticorpo modificado, métodos para preparar e usar as mesmas
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US9155801B2 (en) 2009-05-28 2015-10-13 The United States Government As Represented By The Department Of Veterans Affairs Amino acid sequences which enhance peptide conjugate solubility
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
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PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
JP6921743B2 (ja) 2014-11-05 2021-08-18 ナンヤン テクノロジカル ユニヴァーシティー 安定化かつ自律性抗体ｖｈドメイン
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JPH0651643B2 (ja) * 1983-01-19 1994-07-06 帝人株式会社 殺細胞性修飾免疫グロブリン及びその製造方法
US4625014A (en) * 1984-07-10 1986-11-25 Dana-Farber Cancer Institute, Inc. Cell-delivery agent
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound

Also Published As

Publication number Publication date
NO169958C (no) 1992-08-26
DE3875700D1 (de) 1992-12-10
FI885361L (fi) 1989-05-24
IL88428A0 (en) 1989-06-30
KR910005887B1 (ko) 1991-08-06
NO885199D0 (no) 1988-11-22
EP0317957A2 (en) 1989-05-31
DK651088A (da) 1989-05-24
AU2582488A (en) 1989-05-25
PT89062B (pt) 1993-07-30
NO169958B (no) 1992-05-18
NZ226955A (en) 1991-11-26
EP0317957B1 (en) 1992-11-04
NO885199L (no) 1989-05-24
US4952394A (en) 1990-08-28
FI885361A0 (fi) 1988-11-18
DK651088D0 (da) 1988-11-22
CA1303524C (en) 1992-06-16
EP0317957A3 (en) 1989-07-05
JPH02111731A (ja) 1990-04-24
AU617380B2 (en) 1991-11-28
FI885361A7 (fi) 1989-05-24
PT89062A (pt) 1989-11-30
ATE81986T1 (de) 1992-11-15
KR890007724A (ko) 1989-07-05
ZA886811B (en) 1989-07-26
DE3875700T2 (de) 1993-03-18

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