GEP20125603B - Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents - Google Patents

Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents

Info

Publication number
GEP20125603B
GEP20125603B GEAP200811821A GEAP2008011821A GEP20125603B GE P20125603 B GEP20125603 B GE P20125603B GE AP200811821 A GEAP200811821 A GE AP200811821A GE AP2008011821 A GEAP2008011821 A GE AP2008011821A GE P20125603 B GEP20125603 B GE P20125603B
Authority
GE
Georgia
Prior art keywords
tetrazol
novel
cancer agents
quinazoline derivatives
anti cancer
Prior art date
Application number
GEAP200811821A
Other languages
English (en)
Inventor
Durga Prasad Konakanchi
Subba Rao Pula
Lakshmi Ananthaneli
Reddy Muddasani Pulla
Kali Satya Bhujanga Rao Adibhatla
Chowdary Nannapaneni Venkaiah
Original Assignee
Nacto Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nacto Pharma Ltd filed Critical Nacto Pharma Ltd
Publication of GEP20125603B publication Critical patent/GEP20125603B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GEAP200811821A 2007-10-29 2008-10-28 Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents GEP20125603B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2445CH2007 2007-10-29

Publications (1)

Publication Number Publication Date
GEP20125603B true GEP20125603B (en) 2012-08-10

Family

ID=40433677

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP200811821A GEP20125603B (en) 2007-10-29 2008-10-28 Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents

Country Status (15)

Country Link
US (1) US8080558B2 (enExample)
EP (1) EP2220054A2 (enExample)
JP (1) JP2011502141A (enExample)
KR (1) KR20100087185A (enExample)
CN (1) CN101878203A (enExample)
AU (1) AU2008320342B2 (enExample)
CA (1) CA2703767A1 (enExample)
EA (1) EA018716B1 (enExample)
GE (1) GEP20125603B (enExample)
MX (1) MX2010004625A (enExample)
MY (1) MY150054A (enExample)
NZ (1) NZ585357A (enExample)
UA (1) UA101168C2 (enExample)
WO (1) WO2009057139A2 (enExample)
ZA (1) ZA201002807B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103130729B (zh) * 2011-12-05 2015-07-15 齐鲁制药有限公司 一种4-氯代-7-甲氧基喹唑啉-6-醇乙酸酯的制备方法
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN102993114B (zh) * 2012-10-11 2015-08-12 南通市华峰化工有限责任公司 一种1h-四唑-5-乙酸的生产方法
CN103204817B (zh) * 2013-04-16 2018-03-27 江西师范大学 4‑氰基喹唑啉衍生物的制备方法
DE102013008118A1 (de) * 2013-05-11 2014-11-13 Merck Patent Gmbh Arylchinazoline
HK1244278B (zh) 2015-03-20 2020-04-17 正大天晴药业集团股份有限公司 喹唑啉衍生物的盐及其制备方法
CN114787151B (zh) * 2019-11-01 2024-04-16 正大天晴药业集团股份有限公司 喹唑啉衍生物或其盐、或其药物组合物的用途
CA3193762A1 (en) * 2020-11-23 2022-05-27 F. Hoffmann-La Roche Ag New process for the manufacture of tetrazole derivatives
CN114437041B (zh) * 2022-02-25 2023-11-10 湖北科技学院 一类具有抗肿瘤活性的4-四唑基取代-3，4-二氢喹唑啉衍生物及其制备方法和应用

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JPH078851B2 (ja) 1985-07-29 1995-02-01 鐘淵化学工業株式会社 ３−フエニルチオメチルスチレン誘導体
DE3874257T2 (de) 1987-03-11 1993-02-11 Kanegafuchi Chemical Ind Hydroxystyren-derivate.
AU632992B2 (en) 1987-12-24 1993-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
DE3917982A1 (de) 1989-06-02 1990-12-06 Behringwerke Ag Verwendung von xylanpolyhydrogensulfaten zur therapie von zellproliferations-bedingten erkrankungen
ES2108120T3 (es) 1991-05-10 1997-12-16 Rhone Poulenc Rorer Int Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf.
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ATE402164T1 (de) * 2001-04-26 2008-08-15 Eisai R&D Man Co Ltd Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
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Also Published As

Publication number Publication date
NZ585357A (en) 2012-02-24
EA018716B1 (ru) 2013-10-30
UA101168C2 (ru) 2013-03-11
JP2011502141A (ja) 2011-01-20
AU2008320342A2 (en) 2010-09-02
AU2008320342A1 (en) 2009-05-07
CA2703767A1 (en) 2009-05-07
MY150054A (en) 2013-11-29
KR20100087185A (ko) 2010-08-03
AU2008320342B2 (en) 2012-07-26
US8080558B2 (en) 2011-12-20
MX2010004625A (es) 2010-05-20
WO2009057139A3 (en) 2009-09-24
ZA201002807B (en) 2011-07-27
EA201070543A1 (ru) 2010-12-30
EP2220054A2 (en) 2010-08-25
WO2009057139A2 (en) 2009-05-07
US20100261740A1 (en) 2010-10-14
CN101878203A (zh) 2010-11-03

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