GB985498A - Improvements in or relating to plasmin preparations - Google Patents
Improvements in or relating to plasmin preparationsInfo
- Publication number
- GB985498A GB985498A GB15352/62A GB1535262A GB985498A GB 985498 A GB985498 A GB 985498A GB 15352/62 A GB15352/62 A GB 15352/62A GB 1535262 A GB1535262 A GB 1535262A GB 985498 A GB985498 A GB 985498A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- plasmin
- acid
- amino acid
- millimole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940012957 plasmin Drugs 0.000 title abstract 8
- 238000002360 preparation method Methods 0.000 title abstract 3
- 235000001014 amino acid Nutrition 0.000 abstract 9
- 150000001413 amino acids Chemical class 0.000 abstract 9
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 4
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 2
- 108010008488 Glycylglycine Proteins 0.000 abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 2
- 229930064664 L-arginine Natural products 0.000 abstract 2
- 235000014852 L-arginine Nutrition 0.000 abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- LESXFEZIFXFIQR-LURJTMIESA-N Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)NCC(O)=O LESXFEZIFXFIQR-LURJTMIESA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
- 229940043257 glycylglycine Drugs 0.000 abstract 2
- 108010050848 glycylleucine Proteins 0.000 abstract 2
- 229960003104 ornithine Drugs 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK169161AA DK98833C (da) | 1961-04-25 | 1961-04-25 | Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB985498A true GB985498A (en) | 1965-03-10 |
Family
ID=8107240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15352/62A Expired GB985498A (en) | 1961-04-25 | 1962-04-19 | Improvements in or relating to plasmin preparations |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE616779A (enrdf_load_stackoverflow) |
| CH (1) | CH456848A (enrdf_load_stackoverflow) |
| DK (1) | DK98833C (enrdf_load_stackoverflow) |
| FI (1) | FI43764B (enrdf_load_stackoverflow) |
| FR (1) | FR2140M (enrdf_load_stackoverflow) |
| GB (1) | GB985498A (enrdf_load_stackoverflow) |
| NL (1) | NL147634B (enrdf_load_stackoverflow) |
| NO (1) | NO123024B (enrdf_load_stackoverflow) |
| SE (1) | SE327779B (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2591485A1 (fr) * | 1985-12-17 | 1987-06-19 | Genentech Inc | Compositions stabilisees contenant l'activateur du plasminogene du tissu humain. |
| EP0217379A3 (en) * | 1985-10-02 | 1988-08-31 | Mochida Pharmaceutical Co., Ltd. | Thrombolytic composition and a process for production thereof |
| WO2006122249A3 (en) * | 2005-05-11 | 2007-06-07 | Bausch & Lomb | Use of plasmin for preventing of reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| EP1545588A4 (en) * | 2002-07-23 | 2007-12-05 | Ludwig Inst Cancer Res | METHOD AND COMPOSITIONS FOR THE ACTIVATION OR INHIBITION OF VEGF-D AND VEGF-C |
| US7547435B2 (en) | 2002-12-06 | 2009-06-16 | Thrombogenics Nv | Pharmacological vitreolysis |
| US7871608B2 (en) | 1999-11-13 | 2011-01-18 | Talecris Biotherapeutics, Inc. | Reversibly inactivated acidified plasmin |
| US8268782B2 (en) | 1999-11-13 | 2012-09-18 | Grifols Therapeutics Inc. | Composition and method for preparing plasminogen |
| US8617863B2 (en) | 2008-06-04 | 2013-12-31 | Grifols Therapeutics Inc. | Composition, method, and kit for preparing plasmin |
| US9206410B2 (en) | 2009-03-03 | 2015-12-08 | Grifols Therapeutics Inc. | Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom |
| CN106167797A (zh) * | 2016-07-28 | 2016-11-30 | 武汉生物制品研究所有限责任公司 | 人纤维蛋白溶解酶原的冻干制剂及其制备方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2750159C3 (de) * | 1977-11-09 | 1980-05-22 | Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen | Infusionslösung zur Behandlung von hepatischer Encephalopathie und ein Verfahren zu deren Herstellung |
-
1961
- 1961-04-25 DK DK169161AA patent/DK98833C/da active
-
1962
- 1962-04-16 NO NO144057A patent/NO123024B/no unknown
- 1962-04-18 SE SE04365/62A patent/SE327779B/xx unknown
- 1962-04-19 GB GB15352/62A patent/GB985498A/en not_active Expired
- 1962-04-24 BE BE616779A patent/BE616779A/fr unknown
- 1962-04-25 NL NL62277635A patent/NL147634B/xx not_active IP Right Cessation
- 1962-04-25 CH CH497562A patent/CH456848A/fr unknown
- 1962-04-25 FI FI0828/62A patent/FI43764B/fi active
- 1962-07-20 FR FR904689A patent/FR2140M/fr not_active Expired
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0217379A3 (en) * | 1985-10-02 | 1988-08-31 | Mochida Pharmaceutical Co., Ltd. | Thrombolytic composition and a process for production thereof |
| DE3642960A1 (de) * | 1985-12-17 | 1987-06-19 | Genentech Inc | Stabilisierte zusammensetzungen des menschlichen gewebe-plasminogen-aktivators |
| EP0228862A3 (en) * | 1985-12-17 | 1988-09-28 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
| FR2591485A1 (fr) * | 1985-12-17 | 1987-06-19 | Genentech Inc | Compositions stabilisees contenant l'activateur du plasminogene du tissu humain. |
| US9879246B2 (en) | 1999-11-13 | 2018-01-30 | Grifols Therapeutics Inc. | Reversibly inactivated acidified plasmin composition |
| EP1232251B2 (en) † | 1999-11-13 | 2017-05-17 | Grifols Therapeutics Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US8268782B2 (en) | 1999-11-13 | 2012-09-18 | Grifols Therapeutics Inc. | Composition and method for preparing plasminogen |
| US7871608B2 (en) | 1999-11-13 | 2011-01-18 | Talecris Biotherapeutics, Inc. | Reversibly inactivated acidified plasmin |
| US7887800B2 (en) | 2002-07-23 | 2011-02-15 | Vegenics Limited | Methods for inhibiting VEGF-D |
| EP1545588A4 (en) * | 2002-07-23 | 2007-12-05 | Ludwig Inst Cancer Res | METHOD AND COMPOSITIONS FOR THE ACTIVATION OR INHIBITION OF VEGF-D AND VEGF-C |
| US7479270B2 (en) | 2002-07-23 | 2009-01-20 | Vegenics Limited | Methods and compositions for activating VEGF-D and VEGF-C |
| US7914783B2 (en) | 2002-12-06 | 2011-03-29 | Thrombogenics Nv | Pharmacological vitreolysis |
| US8834869B2 (en) | 2002-12-06 | 2014-09-16 | Thrombogenics Nv | Pharmacological vitreolysis |
| US7803368B2 (en) | 2002-12-06 | 2010-09-28 | Thrombogenics Nv | Pharmacological vitreolysis |
| US8383105B2 (en) | 2002-12-06 | 2013-02-26 | Thrombogenics Nv | Pharmacological vitreolysis |
| US8460655B2 (en) | 2002-12-06 | 2013-06-11 | Thrombogenics Nv | Pharmacological vitreolysis |
| US9770494B2 (en) | 2002-12-06 | 2017-09-26 | Thrombogenics Nv | Pharmacological vitreolysis |
| US8747842B2 (en) | 2002-12-06 | 2014-06-10 | Thrombogenics Nv | Pharmacological vitreolysis |
| US7867489B2 (en) | 2002-12-06 | 2011-01-11 | Thrombogenics Nv | Pharmacological vitreolysis |
| US9186394B2 (en) | 2002-12-06 | 2015-11-17 | Thrombogenics Nv | Pharmacological vitreolysis |
| US7547435B2 (en) | 2002-12-06 | 2009-06-16 | Thrombogenics Nv | Pharmacological vitreolysis |
| WO2006122249A3 (en) * | 2005-05-11 | 2007-06-07 | Bausch & Lomb | Use of plasmin for preventing of reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| US8617863B2 (en) | 2008-06-04 | 2013-12-31 | Grifols Therapeutics Inc. | Composition, method, and kit for preparing plasmin |
| US9206410B2 (en) | 2009-03-03 | 2015-12-08 | Grifols Therapeutics Inc. | Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom |
| CN106167797A (zh) * | 2016-07-28 | 2016-11-30 | 武汉生物制品研究所有限责任公司 | 人纤维蛋白溶解酶原的冻干制剂及其制备方法 |
| CN106167797B (zh) * | 2016-07-28 | 2019-04-09 | 国药集团武汉血液制品有限公司 | 人纤维蛋白溶解酶原的冻干制剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK98833C (da) | 1964-05-25 |
| NL147634B (nl) | 1975-11-17 |
| SE327779B (enrdf_load_stackoverflow) | 1970-08-31 |
| NO123024B (enrdf_load_stackoverflow) | 1971-09-20 |
| FI43764B (enrdf_load_stackoverflow) | 1971-03-01 |
| FR2140M (fr) | 1963-11-12 |
| CH456848A (fr) | 1968-05-31 |
| BE616779A (fr) | 1962-10-24 |
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