GB984303A - Piperazine compounds - Google Patents
Piperazine compoundsInfo
- Publication number
- GB984303A GB984303A GB10223/62A GB1022362A GB984303A GB 984303 A GB984303 A GB 984303A GB 10223/62 A GB10223/62 A GB 10223/62A GB 1022362 A GB1022362 A GB 1022362A GB 984303 A GB984303 A GB 984303A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- formula
- piperazino
- emulsions
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
The invention comprises the compound of formula <FORM:0984303/C2/1> and acid addition salts thereof; and its preparation by reacting a compound of formula <FORM:0984303/C2/2> where Y represents the acid residue of a reactive ester, with 1-b -hydroxyethoxyethylpiperazine. Optical isomers of the product, and its preparation by reacting a compound of formula <FORM:0984303/C2/3> with a compound of formula Q-CH2CH2OH, where either P is piperazino and Q is YCH2CH2O-or P is 4-(b -hydroxyethyl)-piperazino and Q is Y, are also mentioned. 1 - p - Chlorophenyl - 1 - 21 - pyridyl - 1 - chloromethane hydrochloride is obtained from the alcohol with thionyl chloride. 1 - b - hydroxyethylpiperazine is obtained from piperazine and hydroxyethoxyethyl chloride. Pharmaceutical compositions comprise compound I or non-toxic acid addition salts together with pharmaceutical carriers or coatings. Oral (tablets, pills, powders, granules, emulsions, solutions, syrups, elixirs, capsules), rectal (suppositories), and parenteral (solutions, suspensions, emulsions) administration is mentioned. The compounds are anti-histamines.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR856153A FR1383719A (en) | 1961-03-20 | 1961-03-20 | New derivative of piperazine and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB984303A true GB984303A (en) | 1965-02-24 |
Family
ID=8751229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB10223/62A Expired GB984303A (en) | 1961-03-20 | 1962-03-16 | Piperazine compounds |
Country Status (9)
Country | Link |
---|---|
BE (1) | BE615179A (en) |
BR (1) | BR6237209D0 (en) |
CH (1) | CH406226A (en) |
DE (1) | DE1180753B (en) |
ES (1) | ES275615A1 (en) |
FR (2) | FR1383719A (en) |
GB (1) | GB984303A (en) |
NL (1) | NL113511C (en) |
SE (1) | SE301810B (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1061786B (en) * | 1953-10-30 | 1959-07-23 | Henri Morren | Process for the production of new antihistamine active N-mono-benzhydryl-piperazine-Abkoemmlingen |
DE1003738B (en) * | 1954-02-03 | 1957-03-07 | Dr Phil Henri Morren | Process for the preparation of 1,4-aralkylpiperazines |
-
0
- NL NL113511D patent/NL113511C/xx active
- BE BE615179D patent/BE615179A/xx unknown
-
1961
- 1961-03-20 FR FR856153A patent/FR1383719A/en not_active Expired
-
1962
- 1962-03-12 DE DER32266A patent/DE1180753B/en active Pending
- 1962-03-13 SE SE278162A patent/SE301810B/xx unknown
- 1962-03-16 BR BR13720962A patent/BR6237209D0/en unknown
- 1962-03-16 GB GB10223/62A patent/GB984303A/en not_active Expired
- 1962-03-20 FR FR891653A patent/FR1862M/en not_active Expired
- 1962-03-20 CH CH331162A patent/CH406226A/en unknown
- 1962-03-20 ES ES275615A patent/ES275615A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL113511C (en) | |
CH406226A (en) | 1966-01-31 |
SE301810B (en) | 1968-06-24 |
BE615179A (en) | |
BR6237209D0 (en) | 1973-05-31 |
DE1180753B (en) | 1964-11-05 |
FR1862M (en) | 1963-06-17 |
FR1383719A (en) | 1965-01-04 |
ES275615A1 (en) | 1962-05-16 |
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