GB1048903A - Piperazines and process for their manufacture - Google Patents
Piperazines and process for their manufactureInfo
- Publication number
- GB1048903A GB1048903A GB303264A GB303264A GB1048903A GB 1048903 A GB1048903 A GB 1048903A GB 303264 A GB303264 A GB 303264A GB 303264 A GB303264 A GB 303264A GB 1048903 A GB1048903 A GB 1048903A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- phenyl
- chor
- halophenyl
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New compounds of formula <FORM:1048903/C2/1> wherein Ph represents halophenyl, dihalophenyl or trifluoromethylphenyl, R represents lower (i.e. 1-7C) alkyl, R1 represents hydrogen or methyl and Ar represents phenyl, lower alkyl phenyl, lower alkoxy phenyl or halophenyl, and their acid addition salts, are prepared by reaction of N-Ar-C-R1-piperazines with compounds Ph-CHOR-CH2-Y where Y is a reactive esterified hydroxyl group. Optical isomers are mentioned. Haloether starting materials Ph-CHOR-CH2-hal are prepared by reaction of Grignard reagents of Ph-halides with alkoxy-ethylene-1, 2-dihalides. Pharmaceutical compositions comprise the new compounds with carriers. Conventional oral, parenteral and rectal preparations are mentioned. The compounds have anti-inflammatory, anti-hypertensive, adrenolytic, diuretic and saliuretic activities.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25327063A | 1963-01-23 | 1963-01-23 | |
US31534363A | 1963-10-10 | 1963-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1048903A true GB1048903A (en) | 1966-11-23 |
Family
ID=26943082
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB303364A Expired GB1047044A (en) | 1963-01-23 | 1964-01-23 | Piperazines and process for their manufacture |
GB303264A Expired GB1048903A (en) | 1963-01-23 | 1964-01-23 | Piperazines and process for their manufacture |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB303364A Expired GB1047044A (en) | 1963-01-23 | 1964-01-23 | Piperazines and process for their manufacture |
Country Status (7)
Country | Link |
---|---|
AT (10) | AT247346B (en) |
BE (2) | BE642845A (en) |
CH (6) | CH446347A (en) |
ES (2) | ES295631A1 (en) |
FR (2) | FR3309M (en) |
GB (2) | GB1047044A (en) |
NL (2) | NL6400467A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1090913A1 (en) * | 1998-06-30 | 2001-04-11 | Zeria Pharmaceutical Co., Ltd. | N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof |
USD979418S1 (en) * | 2019-06-28 | 2023-02-28 | Seiko Epson Corporation | Packaging container |
USD1009638S1 (en) * | 2019-06-07 | 2024-01-02 | Seiko Epson Corporation | Packaging container |
-
1964
- 1964-01-20 CH CH555567A patent/CH446347A/en unknown
- 1964-01-20 CH CH555767A patent/CH446349A/en unknown
- 1964-01-20 CH CH555467A patent/CH446346A/en unknown
- 1964-01-20 CH CH60264A patent/CH446345A/en unknown
- 1964-01-20 CH CH555667A patent/CH446348A/en unknown
- 1964-01-20 CH CH60164A patent/CH449629A/en unknown
- 1964-01-22 AT AT716064A patent/AT247346B/en active
- 1964-01-22 AT AT716564A patent/AT247351B/en active
- 1964-01-22 BE BE642845A patent/BE642845A/xx unknown
- 1964-01-22 AT AT716464A patent/AT247350B/en active
- 1964-01-22 NL NL6400467A patent/NL6400467A/xx unknown
- 1964-01-22 NL NL6400466A patent/NL6400466A/xx unknown
- 1964-01-22 AT AT49464A patent/AT247337B/en active
- 1964-01-22 AT AT716264A patent/AT247348B/en active
- 1964-01-22 AT AT49364A patent/AT247336B/en active
- 1964-01-22 AT AT716164A patent/AT247347B/en active
- 1964-01-22 BE BE642844A patent/BE642844A/xx unknown
- 1964-01-22 AT AT716364A patent/AT247349B/en active
- 1964-01-22 AT AT715764A patent/AT247343B/en active
- 1964-01-22 AT AT715664A patent/AT247342B/en active
- 1964-01-23 GB GB303364A patent/GB1047044A/en not_active Expired
- 1964-01-23 ES ES295631A patent/ES295631A1/en not_active Expired
- 1964-01-23 GB GB303264A patent/GB1048903A/en not_active Expired
- 1964-01-23 ES ES295632A patent/ES295632A1/en not_active Expired
- 1964-04-14 FR FR970794A patent/FR3309M/en active Active
- 1964-04-14 FR FR970793A patent/FR3308M/en active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1090913A1 (en) * | 1998-06-30 | 2001-04-11 | Zeria Pharmaceutical Co., Ltd. | N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof |
EP1090913A4 (en) * | 1998-06-30 | 2001-11-07 | Zeria Pharm Co Ltd | N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof |
US6395739B1 (en) | 1998-06-30 | 2002-05-28 | Zeria Pharmaceutical Co., Ltd. | N-phenyl-N′-phenylpopylpiperazine derivatives and process for the preparation |
USD1009638S1 (en) * | 2019-06-07 | 2024-01-02 | Seiko Epson Corporation | Packaging container |
USD979418S1 (en) * | 2019-06-28 | 2023-02-28 | Seiko Epson Corporation | Packaging container |
Also Published As
Publication number | Publication date |
---|---|
AT247336B (en) | 1966-06-10 |
NL6400466A (en) | 1964-07-24 |
AT247348B (en) | 1966-06-10 |
AT247346B (en) | 1966-06-10 |
CH446346A (en) | 1967-11-15 |
ES295632A1 (en) | 1964-07-16 |
FR3309M (en) | 1965-05-10 |
AT247343B (en) | 1966-06-10 |
AT247347B (en) | 1966-06-10 |
CH446349A (en) | 1967-11-15 |
CH446345A (en) | 1967-11-15 |
AT247351B (en) | 1966-06-10 |
AT247349B (en) | 1966-06-10 |
CH446347A (en) | 1967-11-15 |
GB1047044A (en) | 1966-11-02 |
CH446348A (en) | 1967-11-15 |
AT247337B (en) | 1966-06-10 |
CH449629A (en) | 1968-01-15 |
AT247342B (en) | 1966-06-10 |
FR3308M (en) | 1965-05-10 |
ES295631A1 (en) | 1964-07-16 |
BE642845A (en) | 1964-07-22 |
NL6400467A (en) | 1964-07-24 |
BE642844A (en) | 1964-07-22 |
AT247350B (en) | 1966-06-10 |
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