ES295631A1 - Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES295631A1
ES295631A1 ES295631A ES295631A ES295631A1 ES 295631 A1 ES295631 A1 ES 295631A1 ES 295631 A ES295631 A ES 295631A ES 295631 A ES295631 A ES 295631A ES 295631 A1 ES295631 A1 ES 295631A1
Authority
ES
Spain
Prior art keywords
formula
compounds
indicated above
meaning indicated
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES295631A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
BASF Schweiz AG
Original Assignee
Ciba Geigy AG
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Ciba AG filed Critical Ciba Geigy AG
Publication of ES295631A1 publication Critical patent/ES295631A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for obtaining piperazine compounds, especially for the preparation of N- (2-OR-2-Ph-ethyl) -N'-Ar-piperazines of the general formula ** (See formula) ** where Ph means a radical of (halogen) -phenyl or (trifluoromethyl) -phenyl, R low alkyl, R1 hydrogen or methyl and Ar phenyl, (lower alkyl) -phenyl, (lower alkoxy) -phenyl, (halogen) -phenyl or pyridyl, its N-oxides or quaternary compounds, characterized in that an N-Ar-piperazine of formula ** (See formula) ** where Ar and R1 have the meaning indicated above, or their salts, are reacted with a reactable ester of a 2-OR-2-Ph-ethanol of the formula ** (See formula) ** where R and Ph have the above meaning and Y means a reactably esterified hydroxyl group, or a 2-OR-2-Ph-ethylamine of formula ** (See formula) ** where Ph and R have the meaning indicated above, is reacted with a N, N-di- (hydroxyethyl) -N-Ar-amine twice reactably esterified, of formula ** (See formula) ** where Ar, R1 and Y have the meaning indicated above, or a N, N-di- (hydroxy-ethyl) -N- (2-OR-2-Ph-ethyl) -amine twice reactably esterified of formula ** (See formula) ** where Ph, R, R1, and Y have the meaning indicated above, is reacted with an amine of formula Ar-NH2, where Ar has the meaning indicated above, or in an N- (2-hydroxy-2-Ph-ethyl) ) -N'-Ar-piperazine of formula ** (See formula) ** where Ph, R and Ar have the meaning indicated above, the hydroxyl group is transformed into a lower alkoxy group, or into an N- (2-OR-2-Ph-acetyl) -N'-Ar-piperazine or an N- - (2-OR-2-Ph-ticacetyl) -N-Ar-piperazine of formula ** (See formula) ** where Ph, R, R1 and Ar have the meaning indicated above and X represents oxygen or a sulfur atom, the carbonyl or thiocarbonyl group is converted to the methylene group, or an N- (2-OR-2-Ph-ethyl) -N'-Ar-ethylenediamine of formula ** (See formula) ** where Ph, R, R1 and Ar have the above meaning, is reacted with a reactable diester of the ethylene glycol of formula Y-ch2-ch2-y XIV where Y has the meaning indicated above and, if desired, the salts obtained are transformed into the free compounds or other salts, and/or, if desired, the obtained compounds are transformed into their N-oxides or quaternary ammonium compounds, and/or, if desired, the obtained compounds, or N-oxides, are transformed into their salts, and/or, if desired, the quaternary ammonium compounds are transformed into other quaternary compounds, and/or, if desired, the isomeric mixtures obtained are separated into the different isomers. (Machine-translation by Google Translate, not legally binding)
ES295631A 1963-01-23 1964-01-23 Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding) Expired ES295631A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25327063A 1963-01-23 1963-01-23
US31534363A 1963-10-10 1963-10-10

Publications (1)

Publication Number Publication Date
ES295631A1 true ES295631A1 (en) 1964-07-16

Family

ID=26943082

Family Applications (2)

Application Number Title Priority Date Filing Date
ES295631A Expired ES295631A1 (en) 1963-01-23 1964-01-23 Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding)
ES295632A Expired ES295632A1 (en) 1963-01-23 1964-01-23 Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES295632A Expired ES295632A1 (en) 1963-01-23 1964-01-23 Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
AT (10) AT247348B (en)
BE (2) BE642845A (en)
CH (6) CH446349A (en)
ES (2) ES295631A1 (en)
FR (2) FR3309M (en)
GB (2) GB1048903A (en)
NL (2) NL6400466A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1090913A4 (en) 1998-06-30 2001-11-07 Zeria Pharm Co Ltd N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof
USD1009638S1 (en) * 2019-06-07 2024-01-02 Seiko Epson Corporation Packaging container
USD979418S1 (en) * 2019-06-28 2023-02-28 Seiko Epson Corporation Packaging container

Also Published As

Publication number Publication date
FR3309M (en) 1965-05-10
ES295632A1 (en) 1964-07-16
AT247337B (en) 1966-06-10
CH449629A (en) 1968-01-15
GB1047044A (en) 1966-11-02
CH446349A (en) 1967-11-15
CH446345A (en) 1967-11-15
FR3308M (en) 1965-05-10
CH446346A (en) 1967-11-15
BE642845A (en) 1964-07-22
AT247348B (en) 1966-06-10
AT247349B (en) 1966-06-10
AT247342B (en) 1966-06-10
AT247343B (en) 1966-06-10
AT247351B (en) 1966-06-10
CH446347A (en) 1967-11-15
AT247336B (en) 1966-06-10
CH446348A (en) 1967-11-15
NL6400467A (en) 1964-07-24
GB1048903A (en) 1966-11-23
AT247346B (en) 1966-06-10
AT247347B (en) 1966-06-10
AT247350B (en) 1966-06-10
BE642844A (en) 1964-07-22
NL6400466A (en) 1964-07-24

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