ES295631A1 - Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES295631A1 ES295631A1 ES295631A ES295631A ES295631A1 ES 295631 A1 ES295631 A1 ES 295631A1 ES 295631 A ES295631 A ES 295631A ES 295631 A ES295631 A ES 295631A ES 295631 A1 ES295631 A1 ES 295631A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- indicated above
- meaning indicated
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for obtaining piperazine compounds, especially for the preparation of N- (2-OR-2-Ph-ethyl) -N'-Ar-piperazines of the general formula ** (See formula) ** where Ph means a radical of (halogen) -phenyl or (trifluoromethyl) -phenyl, R low alkyl, R1 hydrogen or methyl and Ar phenyl, (lower alkyl) -phenyl, (lower alkoxy) -phenyl, (halogen) -phenyl or pyridyl, its N-oxides or quaternary compounds, characterized in that an N-Ar-piperazine of formula ** (See formula) ** where Ar and R1 have the meaning indicated above, or their salts, are reacted with a reactable ester of a 2-OR-2-Ph-ethanol of the formula ** (See formula) ** where R and Ph have the above meaning and Y means a reactably esterified hydroxyl group, or a 2-OR-2-Ph-ethylamine of formula ** (See formula) ** where Ph and R have the meaning indicated above, is reacted with a N, N-di- (hydroxyethyl) -N-Ar-amine twice reactably esterified, of formula ** (See formula) ** where Ar, R1 and Y have the meaning indicated above, or a N, N-di- (hydroxy-ethyl) -N- (2-OR-2-Ph-ethyl) -amine twice reactably esterified of formula ** (See formula) ** where Ph, R, R1, and Y have the meaning indicated above, is reacted with an amine of formula Ar-NH2, where Ar has the meaning indicated above, or in an N- (2-hydroxy-2-Ph-ethyl) ) -N'-Ar-piperazine of formula ** (See formula) ** where Ph, R and Ar have the meaning indicated above, the hydroxyl group is transformed into a lower alkoxy group, or into an N- (2-OR-2-Ph-acetyl) -N'-Ar-piperazine or an N- - (2-OR-2-Ph-ticacetyl) -N-Ar-piperazine of formula ** (See formula) ** where Ph, R, R1 and Ar have the meaning indicated above and X represents oxygen or a sulfur atom, the carbonyl or thiocarbonyl group is converted to the methylene group, or an N- (2-OR-2-Ph-ethyl) -N'-Ar-ethylenediamine of formula ** (See formula) ** where Ph, R, R1 and Ar have the above meaning, is reacted with a reactable diester of the ethylene glycol of formula Y-ch2-ch2-y XIV where Y has the meaning indicated above and, if desired, the salts obtained are transformed into the free compounds or other salts, and/or, if desired, the obtained compounds are transformed into their N-oxides or quaternary ammonium compounds, and/or, if desired, the obtained compounds, or N-oxides, are transformed into their salts, and/or, if desired, the quaternary ammonium compounds are transformed into other quaternary compounds, and/or, if desired, the isomeric mixtures obtained are separated into the different isomers. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25327063A | 1963-01-23 | 1963-01-23 | |
| US31534363A | 1963-10-10 | 1963-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES295631A1 true ES295631A1 (en) | 1964-07-16 |
Family
ID=26943082
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES295632A Expired ES295632A1 (en) | 1963-01-23 | 1964-01-23 | Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding) |
| ES295631A Expired ES295631A1 (en) | 1963-01-23 | 1964-01-23 | Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES295632A Expired ES295632A1 (en) | 1963-01-23 | 1964-01-23 | Procedure for obtaining piperacinic compounds (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| AT (10) | AT247346B (en) |
| BE (2) | BE642845A (en) |
| CH (6) | CH446349A (en) |
| ES (2) | ES295632A1 (en) |
| FR (2) | FR3309M (en) |
| GB (2) | GB1048903A (en) |
| NL (2) | NL6400466A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0102609A3 (en) | 1998-06-30 | 2002-12-28 | Zeria Pharm Co Ltd | N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof, and pharmaceutical compositions containing them |
| USD1009638S1 (en) * | 2019-06-07 | 2024-01-02 | Seiko Epson Corporation | Packaging container |
| USD979418S1 (en) * | 2019-06-28 | 2023-02-28 | Seiko Epson Corporation | Packaging container |
-
1964
- 1964-01-20 CH CH555767A patent/CH446349A/en unknown
- 1964-01-20 CH CH60264A patent/CH446345A/en unknown
- 1964-01-20 CH CH555667A patent/CH446348A/en unknown
- 1964-01-20 CH CH555567A patent/CH446347A/en unknown
- 1964-01-20 CH CH60164A patent/CH449629A/en unknown
- 1964-01-20 CH CH555467A patent/CH446346A/en unknown
- 1964-01-22 AT AT716064A patent/AT247346B/en active
- 1964-01-22 AT AT716464A patent/AT247350B/en active
- 1964-01-22 AT AT716364A patent/AT247349B/en active
- 1964-01-22 AT AT49464A patent/AT247337B/en active
- 1964-01-22 BE BE642845A patent/BE642845A/xx unknown
- 1964-01-22 AT AT716264A patent/AT247348B/en active
- 1964-01-22 AT AT715664A patent/AT247342B/en active
- 1964-01-22 AT AT715764A patent/AT247343B/en active
- 1964-01-22 AT AT716164A patent/AT247347B/en active
- 1964-01-22 AT AT49364A patent/AT247336B/en active
- 1964-01-22 NL NL6400466A patent/NL6400466A/xx unknown
- 1964-01-22 BE BE642844A patent/BE642844A/xx unknown
- 1964-01-22 NL NL6400467A patent/NL6400467A/xx unknown
- 1964-01-22 AT AT716564A patent/AT247351B/en active
- 1964-01-23 GB GB303264A patent/GB1048903A/en not_active Expired
- 1964-01-23 GB GB303364A patent/GB1047044A/en not_active Expired
- 1964-01-23 ES ES295632A patent/ES295632A1/en not_active Expired
- 1964-01-23 ES ES295631A patent/ES295631A1/en not_active Expired
- 1964-04-14 FR FR970794A patent/FR3309M/en active Active
- 1964-04-14 FR FR970793A patent/FR3308M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR3308M (en) | 1965-05-10 |
| AT247349B (en) | 1966-06-10 |
| CH446345A (en) | 1967-11-15 |
| GB1047044A (en) | 1966-11-02 |
| AT247351B (en) | 1966-06-10 |
| BE642844A (en) | 1964-07-22 |
| CH449629A (en) | 1968-01-15 |
| NL6400466A (en) | 1964-07-24 |
| CH446347A (en) | 1967-11-15 |
| AT247348B (en) | 1966-06-10 |
| AT247337B (en) | 1966-06-10 |
| AT247346B (en) | 1966-06-10 |
| AT247350B (en) | 1966-06-10 |
| CH446349A (en) | 1967-11-15 |
| AT247347B (en) | 1966-06-10 |
| AT247342B (en) | 1966-06-10 |
| ES295632A1 (en) | 1964-07-16 |
| CH446346A (en) | 1967-11-15 |
| NL6400467A (en) | 1964-07-24 |
| CH446348A (en) | 1967-11-15 |
| GB1048903A (en) | 1966-11-23 |
| AT247343B (en) | 1966-06-10 |
| BE642845A (en) | 1964-07-22 |
| FR3309M (en) | 1965-05-10 |
| AT247336B (en) | 1966-06-10 |
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