ES446106A1 - A procedure for the production of an aminoalkilic ester of a 2,6-dialkyl (bottom) -4-phenyl substitute-1,4-dihydropyridin-3-carboxylic acid. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the production of an aminoalkilic ester of a 2,6-dialkyl (bottom) -4-phenyl substitute-1,4-dihydropyridin-3-carboxylic acid. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES446106A1
ES446106A1 ES446106A ES446106A ES446106A1 ES 446106 A1 ES446106 A1 ES 446106A1 ES 446106 A ES446106 A ES 446106A ES 446106 A ES446106 A ES 446106A ES 446106 A1 ES446106 A1 ES 446106A1
Authority
ES
Spain
Prior art keywords
formula
group
given above
dialkyl
meaning given
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES446106A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES446106A1 publication Critical patent/ES446106A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A process for the production of an aminoalkyl ester of 2,6-dialkyl (lower) -4-substituted phenyl-1,4-dihydropyridin-3-carboxylic acid represented by the formula: **(See formula)** where R represents a hydrogen atom or a lower alkyl group; R1 and R2, which may be the same or different, each represent a lower alkyl group; R3 represents a phenyl group that can contain a substituent or an aralkyl group that can, contain a substituent; represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group; R5 represents a lower alkyl group, a lower alkoxy group which may be substituted with a lower alkoxy group or a group (see formula) (where A, R3 and R4 have the meaning given above) and R6 represents a nitro group or a trifluoromethyl group ; whose procedure is to react a benzaldehyde derivative represented by the formula: **(See formula)** where R6 has the meaning given above, with an enamine represented by the formula **(See formula)** where R, R1 and R5 have the meaning given above and a haloalkyl ester of an alkanoylacetic acid represented by the formula **(See formula)** where X represents a halogen atom and R2 has the meaning given above, to form a haloalkyl ester of 2,6-dialkyl (lower) -4-substituted phenyl-3-carboxylic acid and then react the product thus obtained with a amine represented by the formula **(See formula)** where R3 and R4 have the meaning given above. (Machine-translation by Google Translate, not legally binding)
ES446106A 1973-04-20 1976-03-16 A procedure for the production of an aminoalkilic ester of a 2,6-dialkyl (bottom) -4-phenyl substitute-1,4-dihydropyridin-3-carboxylic acid. (Machine-translation by Google Translate, not legally binding) Expired ES446106A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4482173A JPS5714348B2 (en) 1973-04-20 1973-04-20

Publications (1)

Publication Number Publication Date
ES446106A1 true ES446106A1 (en) 1977-09-16

Family

ID=12702097

Family Applications (1)

Application Number Title Priority Date Filing Date
ES446106A Expired ES446106A1 (en) 1973-04-20 1976-03-16 A procedure for the production of an aminoalkilic ester of a 2,6-dialkyl (bottom) -4-phenyl substitute-1,4-dihydropyridin-3-carboxylic acid. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
JP (1) JPS5714348B2 (en)
CH (1) CH613192A5 (en)
ES (1) ES446106A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6094963A (en) * 1983-10-31 1985-05-28 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative and production thereof

Also Published As

Publication number Publication date
CH613192A5 (en) 1979-09-14
JPS5714348B2 (en) 1982-03-24
JPS49127979A (en) 1974-12-07

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