Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
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Publication date
Application filed by American Cyanamid CofiledCriticalAmerican Cyanamid Co
Priority to ES0304350ApriorityCriticalpatent/ES304350A2/en
Publication of ES304350A2publicationCriticalpatent/ES304350A2/en
Improvements introduced in the object of the Main Patent no. 291,187, that is, in the process for preparing substituted piperazines of the formula ** (See formula) ** where n is 3 or 4; R1 and R2 are each hydrogen atoms or lower alkyl radicals; R3 and R4 are each hydrogen atoms, or lower aralkyl or alkyl radicals; and R5 is an alkyl, alkoxy, or aryl radical, and Y is -SO2- or (see formula), characterized by reacting a piperazine derivative of the formula wherein R1, R2, R3, R4 and n are as defined above, with: (a) a sulfonyl halide of the formula R5SO2Cl wherein R5 is an alkyl or aryl radical; or (b) an amidating agent capable of inserting the group (see formula) wherein R5 is an alkyl, alkoxy or aryl radical; (c) and, if desired, form pharmaceutically acceptable salts. (Machine-translation by Google Translate, not legally binding)
ES0304350A1964-09-241964-09-24A procedure for preparing substitute piperations. (Machine-translation by Google Translate, not legally binding)
ExpiredES304350A2
(en)
Procedure for preparing N-alcohilamino-alcohilic derivatives of espirotetralinosuccinimidas and their salts. (Machine-translation by Google Translate, not legally binding)