GB969126A - Substituted oxazolidinones - Google Patents
Substituted oxazolidinonesInfo
- Publication number
- GB969126A GB969126A GB40356/62A GB4035662A GB969126A GB 969126 A GB969126 A GB 969126A GB 40356/62 A GB40356/62 A GB 40356/62A GB 4035662 A GB4035662 A GB 4035662A GB 969126 A GB969126 A GB 969126A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- reacting
- compound
- chloro
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 3
- -1 chloro-hydroxy-propyl compound Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- WMRXHQRDCIXTCD-UHFFFAOYSA-N 3-hydrazinylpropan-1-ol Chemical compound NNCCCO WMRXHQRDCIXTCD-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- RFPDIKCSEDYLKW-UHFFFAOYSA-N 5-amino-1,3-oxazolidin-2-one Chemical compound NC1CNC(=O)O1 RFPDIKCSEDYLKW-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012050 conventional carrier Substances 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1541862 | 1962-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB969126A true GB969126A (en) | 1964-09-09 |
Family
ID=11148002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40356/62A Expired GB969126A (en) | 1962-08-01 | 1962-10-25 | Substituted oxazolidinones |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3288787A (forum.php) |
| BE (1) | BE635608A (forum.php) |
| CH (1) | CH432525A (forum.php) |
| FR (1) | FR1588152A (forum.php) |
| GB (1) | GB969126A (forum.php) |
| MY (1) | MY6700099A (forum.php) |
| NL (2) | NL120945C (forum.php) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103232445A (zh) * | 2013-05-02 | 2013-08-07 | 中国医药研究开发中心有限公司 | 一种制备硝呋太尔的方法 |
| EP2662371A1 (en) | 2012-05-11 | 2013-11-13 | Polichem SA | (R)-Nifuratel and synthesis of (R) and (S)-Nifuratel |
| CN108440354A (zh) * | 2018-04-13 | 2018-08-24 | 北京朗依制药有限公司沧州分公司 | 利用环氧丙甲硫醚废渣生产3-甲硫基-2-羟基-丙基肼的方法 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093627A (en) * | 1977-07-01 | 1978-06-06 | Morton-Norwich Products, Inc. | 3-[(4-Chromanylidene)amino]-2-oxazolidinones |
| EP0599968B1 (en) * | 1991-08-14 | 2000-01-12 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Oxazolidinone derivatives useful as antiarrhythmic and antifibrillatory agents |
| CN101676284B (zh) * | 2008-09-17 | 2013-12-04 | 北京德众万全药物技术开发有限公司 | 一种高纯度的硝呋太尔的制备方法 |
| EP2610253A1 (en) * | 2011-12-27 | 2013-07-03 | Polichem SA | Nifuratel sulfoxide for use in the treatment of bacterial infections. |
| CN103396413A (zh) * | 2013-08-14 | 2013-11-20 | 盐城凯利药业有限公司 | 一种硝呋太尔的制备方法 |
| CN103664923B (zh) * | 2013-12-23 | 2016-05-11 | 湖南方盛制药股份有限公司 | 硝呋太尔的制备方法 |
| CN114478510B (zh) * | 2022-02-24 | 2022-11-01 | 盐城凯利药业有限公司 | 一种硝呋太尔的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2511838A (en) * | 1950-06-20 | Therapeutic fungicidal composition | ||
| US2556567A (en) * | 1949-04-01 | 1951-06-12 | Tampax Inc | Douche composition |
| US2742462A (en) * | 1952-02-28 | 1956-04-17 | Norwich Pharma Co | New n-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidones |
| US3102144A (en) * | 1954-09-15 | 1963-08-27 | Fmc Corp | Methylated derivatives of hydrazine |
| US2802002A (en) * | 1956-07-18 | 1957-08-06 | Norwich Pharma Co | Series of new nu-(5-nitro-2-furyl) alkylidene-3-amino-5-tertiaryamino-methyl-2-oxazolidones and the preparation thereof |
| US3040098A (en) * | 1956-12-17 | 1962-06-19 | Monsanto Chemicals | Sulfur-nitrogen polymer derived from sulfur dichloride and monomethylamine |
| NL104211C (forum.php) * | 1958-02-28 | |||
| US3004888A (en) * | 1959-01-12 | 1961-10-17 | Pfizer & Co C | Mastitis treatment |
-
0
- NL NL295684D patent/NL295684A/xx unknown
- BE BE635608D patent/BE635608A/xx unknown
- NL NL120945D patent/NL120945C/xx active
-
1962
- 1962-10-25 GB GB40356/62A patent/GB969126A/en not_active Expired
-
1963
- 1963-07-25 US US297696A patent/US3288787A/en not_active Expired - Lifetime
- 1963-07-26 CH CH944263A patent/CH432525A/de unknown
- 1963-07-31 FR FR1588152D patent/FR1588152A/fr not_active Expired
-
1967
- 1967-12-31 MY MY196799A patent/MY6700099A/xx unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2662371A1 (en) | 2012-05-11 | 2013-11-13 | Polichem SA | (R)-Nifuratel and synthesis of (R) and (S)-Nifuratel |
| WO2013167295A1 (en) | 2012-05-11 | 2013-11-14 | Polichem Sa | (r) -nifuratel, its use for the treatment of infections and synthesis of (r) and (s) -nifuratel |
| CN104379580A (zh) * | 2012-05-11 | 2015-02-25 | 波利化学公司 | (r)-硝呋太尔,其治疗感染的用途以及(r)和(s)-硝呋太尔的合成 |
| JP2015515998A (ja) * | 2012-05-11 | 2015-06-04 | ポリケム・エスエイ | (r)−ニフラテル、感染を治療するためのその使用ならびに(r)および(s)−ニフラテルの合成 |
| US9067927B2 (en) | 2012-05-11 | 2015-06-30 | Polichem Sa | (R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel |
| US9284306B2 (en) | 2012-05-11 | 2016-03-15 | Polichem Sa | (R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel |
| CN103232445A (zh) * | 2013-05-02 | 2013-08-07 | 中国医药研究开发中心有限公司 | 一种制备硝呋太尔的方法 |
| CN108440354A (zh) * | 2018-04-13 | 2018-08-24 | 北京朗依制药有限公司沧州分公司 | 利用环氧丙甲硫醚废渣生产3-甲硫基-2-羟基-丙基肼的方法 |
| CN108440354B (zh) * | 2018-04-13 | 2019-09-13 | 北京金城泰尔制药有限公司沧州分公司 | 利用环氧丙甲硫醚废渣生产3-甲硫基-2-羟基-丙基肼的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| MY6700099A (en) | 1967-12-31 |
| BE635608A (forum.php) | |
| NL120945C (forum.php) | |
| FR1588152A (forum.php) | 1970-04-10 |
| NL295684A (forum.php) | |
| CH432525A (de) | 1967-03-31 |
| US3288787A (en) | 1966-11-29 |
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