GB945157A - Improvements in or relating to processes for the production of steroid compounds and the compounds thus produced - Google Patents

Improvements in or relating to processes for the production of steroid compounds and the compounds thus produced

Info

Publication number
GB945157A
GB945157A GB2121460A GB2121460A GB945157A GB 945157 A GB945157 A GB 945157A GB 2121460 A GB2121460 A GB 2121460A GB 2121460 A GB2121460 A GB 2121460A GB 945157 A GB945157 A GB 945157A
Authority
GB
United Kingdom
Prior art keywords
compounds
pregn
processes
methylene
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2121460A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB945157A publication Critical patent/GB945157A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 12-methylene-pregn-4-en-3,20-dione, 3,20-bisethylenedioxy - 12 - methylene - pregn - 5- ene, 3 - ethylenedioxy - 12 - methylene - pregn - 5 - en - 20 - one and processes for the preparation of 12-methylenepregna-3,20-dione compounds by reacting a pregna-3,12,20-trione or a derivative thereof having an unprotected 12-keto group with a Grignard reagent to form the corresponding 12 #x-hydroxy -12 #x-methyl-derivative and dehydrating the latter to form the desired compound. Keto groups other than in 12-position may be protected for example by conversion to ethylenedioxy groups and may be regenerated either before or after dehydration of the 12-hydroxy - 12 - methyl derivative. The starting 3,20-bisethylenedioxy-pregn -5-en -12-one may be obtained by ketalising 12-hydroxyprogesterone with ethylene glycol and oxidising the 12-hydroxy substituent. Specification 945,158 is referred to.
GB2121460A 1959-06-18 1960-06-16 Improvements in or relating to processes for the production of steroid compounds and the compounds thus produced Expired GB945157A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR797893A FR1357602A (en) 1959-06-18 1959-06-18 Process for the preparation of steroids substituted in position 12 and products thereof

Publications (1)

Publication Number Publication Date
GB945157A true GB945157A (en) 1963-12-23

Family

ID=8716205

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2121460A Expired GB945157A (en) 1959-06-18 1960-06-16 Improvements in or relating to processes for the production of steroid compounds and the compounds thus produced
GB4595962A Expired GB945158A (en) 1959-06-18 1960-06-16 New steroid compounds and processes for their formation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4595962A Expired GB945158A (en) 1959-06-18 1960-06-16 New steroid compounds and processes for their formation

Country Status (5)

Country Link
BE (1) BE592005A (en)
CH (1) CH395074A (en)
ES (1) ES259017A1 (en)
FR (1) FR1357602A (en)
GB (2) GB945157A (en)

Also Published As

Publication number Publication date
ES259017A1 (en) 1960-09-16
GB945158A (en) 1963-12-23
CH395074A (en) 1965-07-15
FR1357602A (en) 1964-04-10
BE592005A (en) 1960-12-19

Similar Documents

Publication Publication Date Title
GB945157A (en) Improvements in or relating to processes for the production of steroid compounds and the compounds thus produced
GB931222A (en) Steroid compounds
ES276465A1 (en) Procedure for preparing derivatives of 19-nor-testosterone (Machine-translation by Google Translate, not legally binding)
GB841003A (en) Improvements in or relating to 6-methyl steroid compounds
GB967080A (en) Novel steroid compounds and process for the preparation thereof
GB934711A (en) New steroid compounds and processes for their preparation and conversion into substituted corticosteroids
GB948269A (en) Process for the manufacture of 16.17-methylene-20-keto-steroids
GB919686A (en) Improvements in or relating to the manufacture of steroids
GB894168A (en) New steroid compounds and processes for their production
GB892440A (en) Improvements in or relating to the production of steroids and the compounds thus produced
GB933279A (en) New steroid compounds and their formation
GB946874A (en) New steroid compounds, and processes for the preparation thereof
GB965929A (en) Novel steroid compounds and their production
ES268064A1 (en) A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding)
GB952492A (en) New steroid compounds and processes for their preparation
GB934708A (en) New steroid compounds and their production
GB904067A (en) Steroids
GB973144A (en) Process for the manufacture of 18:20-lactones of the pregnane series
GB945507A (en) New steroid compounds, their production and conversion
GB970484A (en) New 17-desoxy corticosteroids and processes for their preparation
GB908284A (en) Steroid alkyl ethers and a process for their manufacture
GB908770A (en) A new steroid compound and its formation
DK100875C (en) Process for the preparation of 11β, 17α, 21-trihydroxy-9 & alpha-fluor-16α-methyl-1,4-pregnadiene-3,20-dione or 21-esters thereof with carboxylic acids having up to 8 carbon atoms.
GB955613A (en) New steroid compounds and processes
GB1069709A (en) New steroid compounds,compositions incorporating them,and processes for their preparation