ES268064A1 - A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding) - Google Patents

A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding)

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Publication number
ES268064A1
ES268064A1 ES0268064A ES268064A ES268064A1 ES 268064 A1 ES268064 A1 ES 268064A1 ES 0268064 A ES0268064 A ES 0268064A ES 268064 A ES268064 A ES 268064A ES 268064 A1 ES268064 A1 ES 268064A1
Authority
ES
Spain
Prior art keywords
series
androstano
ceto
trifluoromethyl
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0268064A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOVENS KEMISKE FABRIK VED A KO
Original Assignee
DOVENS KEMISKE FABRIK VED A KO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOVENS KEMISKE FABRIK VED A KO filed Critical DOVENS KEMISKE FABRIK VED A KO
Publication of ES268064A1 publication Critical patent/ES268064A1/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

A method for the production of 3-keto Δ 4,6-6-trifluoromethyl steroids and 3-keto- Δ 1,4,6-6-trifluoromethyl steroids of the androstane series, of the 19-nor-androstane series , and of the pregnane series, and the 19-nor-pregnane series, characterized in that the 3-keto- Δ 4-6- α -trifluoromethyl steroid of one of said series, in which the group of 3- keto has been transformed into a cyclic ketal group is reacted with N-bromosuccinamide, in which the reaction product is dehydrobrominated and subsequently the ketal group is removed by acid hydrolysis after which if it is desired to achieve a 3-ketocyte steroid Δ 1,4,6-6-trifluoromethyl, the 3-keto- Δ 4,6-6-trifluoromethyl steroid thus obtained is dehydrogenated in the manner known per se. (Machine-translation by Google Translate, not legally binding)
ES0268064A 1960-06-08 1961-06-08 A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding) Expired ES268064A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2019060 1960-06-08

Publications (1)

Publication Number Publication Date
ES268064A1 true ES268064A1 (en) 1961-11-16

Family

ID=10141901

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0268064A Expired ES268064A1 (en) 1960-06-08 1961-06-08 A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
CH (1) CH401960A (en)
DK (1) DK102857C (en)
ES (1) ES268064A1 (en)

Also Published As

Publication number Publication date
DK102857C (en) 1965-10-18
CH401960A (en) 1965-11-15

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