ES250766A1 - Chemical procedure for the obtaining of new esteroid compounds of the pregnant series (Machine-translation by Google Translate, not legally binding)
- Google Patents
Chemical procedure for the obtaining of new esteroid compounds of the pregnant series (Machine-translation by Google Translate, not legally binding)
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Merck and Co Inc
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Merck and Co Inc
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Publication of ES250766A1publicationCriticalpatent/ES250766A1/en
Chemical procedure for obtaining new steroid compounds of the pregnane series, especially to prepare a Δ 4-11-oxido-6 α -fluoro-16 β -methyl-pregnen-l7 α, 21-diol-3.20- dione, which comprises treating a Δ 5-11-oxido-17-20,20-21-bismethylenedioxy-16 β -methyl-3-ethylenedioxy-pregnene with a peracid, to produce an 11-oxide-19-20,20 -21-bismethylenedioxy-5 α, 6 α, epoxy-16 β -methyl-3-ethylene-dioxy-pregnane; reacting the latter substance with hydrogen fluoride, to form an 11-oxido-17-20,20-21-bismethylenedioxy-5 α -hydroxy-6 β -fluoro-16 β -methyl-3-ethylene-dioxy-pregnane; treat this material with an acid, to form a " 4-11-oxido-l7-20,20-21-bismethylenedioxy-6 β -fluoro-16 β -methyl-pregnen-3-one; and placing the latter steroid in succession in contact with aqueous formic acid and a dry mineral acid, to produce Δ 4-11-oxide-6 α -fluoro-16 β -methylpregnen-l7 α, 21-diol-3,20-dione ; electing the 11-oxidosubstitute of these steroids, of the class comprising ketone and hydroxyl groups. (Machine-translation by Google Translate, not legally binding)
ES0250766A1958-07-071959-07-04Chemical procedure for the obtaining of new esteroid compounds of the pregnant series (Machine-translation by Google Translate, not legally binding)
ExpiredES250766A1
(en)
A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding)