ES250664A1 - Chemical procedure for the obtaining of new steroid compounds of the pregnan series (Machine-translation by Google Translate, not legally binding) - Google Patents

Chemical procedure for the obtaining of new steroid compounds of the pregnan series (Machine-translation by Google Translate, not legally binding)

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Publication number
ES250664A1
ES250664A1 ES0250664A ES250664A ES250664A1 ES 250664 A1 ES250664 A1 ES 250664A1 ES 0250664 A ES0250664 A ES 0250664A ES 250664 A ES250664 A ES 250664A ES 250664 A1 ES250664 A1 ES 250664A1
Authority
ES
Spain
Prior art keywords
methyl
bismethylenedioxy
fluoro
oxide
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0250664A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES250664A1 publication Critical patent/ES250664A1/en
Expired legal-status Critical Current

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Abstract

Chemical procedure for obtaining new steroid compounds of the pregnane series, especially to prepare a Δ 4-11-oxide-6 α -fluoro-19 α -methyl-pregnen-17 α, 21-diol-3.20- dione, which comprises treating a Δ 5 -11-oxide-17-20,20-21-bismethylenedioxy-16 α -methyl-3-ethylenedioxy-pregnene with a peracid, to produce an 11-oxido-17-20.20 -21-bismethylenedioxy-5 α, 6 α -epoxy-16 α -methyl-3-ethylenedioxy-pregnane; reacting the latter substance with hydrogen fluoride, to form an 11-oxide-17,20,20-21-bismethylenedioxy-5 α -hydroxy-6 β -fluoro-16 α -methyl-3-ethylenedioxy-pregnane; treat this material with an acid, to form a " 4-11-oxide-17-20,20-21-bismethylenedioxy-6 β -fluoro-16 α -methyl-prognen-3-one; and placing the latter steroid in succession in contact with aqueous formic acid and a dry mineral acid, to produce 11-oxido-6 α -fluoro-16 α -methyl-pregnen-17 α, 21-diol-3,20-dione; electing the 11-oxidosubstitute of these steroids, of the class comprising ketone and hydroxyl groups. (Machine-translation by Google Translate, not legally binding)
ES0250664A 1958-07-07 1959-07-01 Chemical procedure for the obtaining of new steroid compounds of the pregnan series (Machine-translation by Google Translate, not legally binding) Expired ES250664A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74666158A 1958-07-07 1958-07-07

Publications (1)

Publication Number Publication Date
ES250664A1 true ES250664A1 (en) 1960-02-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES0250664A Expired ES250664A1 (en) 1958-07-07 1959-07-01 Chemical procedure for the obtaining of new steroid compounds of the pregnan series (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES250664A1 (en)

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