Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36667/56A
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Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
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Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co IncfiledCriticalPfizer Inc
Publication of GB804523ApublicationCriticalpatent/GB804523A/en
C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Health & Medical Sciences
(AREA)
General Health & Medical Sciences
(AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts
(AREA)
Steroid Compounds
(AREA)
Abstract
The invention comprises 21-hydroxypregnane-3,20-dione and the corresponding allopregnane compound and a process for preparing a steroid compound by hydrogenating desoxycorticosterone to produce 21-hydroxypregnane-3,20-dione, the hydrogenation being effected as described in Example (1). 21-Hydroxyallopregnane is obtained by hydrolysing 21-acetoxy-allopregnane, which has been produced by hydrogenating 21-acetoxy- D 5-pregnen-3b -ol-20-one and oxidizing the resulting 21-acetoxyallopregnan-3b -ol-20-one. In Example (1) desoxycorticosterone is hydrogenated in the presence of a palladium/calcium carbonate catalyst to produce 21-hydroxypregnane-3,20-dione; in Example (2) 21-acetoxyallopregnane is hydrolized to 21-hydroxyallopregnane. The 21-acetoxyallopregnane is obtained as described above or by hydrogenating desoxycorticosterone acetate over a palladium calciumcatalyst. Specification 804,522 is referred to.
GB36667/56A1954-10-211955-05-17Steroids and the preparation thereof
ExpiredGB804523A
(en)
A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding)
A method for the production of 3-ceto-delta-4,6-alpha-trifluoromethyl-steroids and 3-ceto-delta-1,4-6 alpha-trifluoromethyl-steroids of the androstano series, of the pergnano series, of the 19-nor-androstano series and the 19-nor-pregnano series and their 3-nor-esteres (Machine-translation by Google Translate, not legally binding)