GB973144A - Process for the manufacture of 18:20-lactones of the pregnane series - Google Patents

Process for the manufacture of 18:20-lactones of the pregnane series

Info

Publication number
GB973144A
GB973144A GB4255260A GB4255260A GB973144A GB 973144 A GB973144 A GB 973144A GB 4255260 A GB4255260 A GB 4255260A GB 4255260 A GB4255260 A GB 4255260A GB 973144 A GB973144 A GB 973144A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
oxo
lactones
oxidation
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4255260A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH6947559A external-priority patent/CH383953A/en
Priority claimed from CH8178059A external-priority patent/CH407111A/en
Priority claimed from CH185860A external-priority patent/CH432510A/en
Priority claimed from CH337560A external-priority patent/CH441300A/en
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB973144A publication Critical patent/GB973144A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

18,20-Lactones of 20-hydroxy-pregnane-18-acids are prepared by oxidizing cyclic 18,20-semiacetals of 18-oxo-20-hydroxy-pregnanes or their 18-hydriodic acid esters. The oxidation is preferably effected with a compound of hexavalent chromium. Concomitant oxidation of other free secondary hydroxyl groups also occurs. The preparation of the starting materials is described in Specification 973,143. Detailed examples are given, a byproduct in the oxidation of D 4,9(11)-3-oxo -18- hydroxy - 18, 20 - oxido-pregnadiene being the 18, 20-lactone of D 4,9(11)-3-oxo-12-acetoxy - 20b -hydroxy-pregnadiene-18-acid. Specification 973,145 also is referred to.
GB4255260A 1959-02-12 1960-12-09 Process for the manufacture of 18:20-lactones of the pregnane series Expired GB973144A (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CH6947559A CH383953A (en) 1959-02-12 1959-02-12 Process for the preparation of 18,20-oxido-steroids
CH7244359 1959-04-23
CH7375459 1959-05-29
CH8178059A CH407111A (en) 1959-12-11 1959-12-11 Process for the production of new hydroxyaldehydes of the Pregnan range
CH8223359 1959-12-22
CH185860A CH432510A (en) 1959-02-12 1960-02-18 Process for the preparation of 18,20-lactones of the pregnan and 19-nor-pregnan series
CH337560A CH441300A (en) 1960-03-25 1960-03-25 Process for the preparation of 18,11-lactones from 11B-hydroxy-20-oxo-steroid-18-acids of the pregnane and 19-nor-pregnane series
CH835460 1960-07-21

Publications (1)

Publication Number Publication Date
GB973144A true GB973144A (en) 1964-10-21

Family

ID=31721975

Family Applications (3)

Application Number Title Priority Date Filing Date
GB4255160A Expired GB973143A (en) 1959-02-12 1960-12-09 New hydroxy-aldehydes of the pregnane series and functional derivatives thereof and a process for their manufacture
GB4255260A Expired GB973144A (en) 1959-02-12 1960-12-09 Process for the manufacture of 18:20-lactones of the pregnane series
GB4255360A Expired GB973145A (en) 1959-02-12 1960-12-09 New 18,20-lactones of 20-hydroxy-pregnane-18-acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4255160A Expired GB973143A (en) 1959-02-12 1960-12-09 New hydroxy-aldehydes of the pregnane series and functional derivatives thereof and a process for their manufacture

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4255360A Expired GB973145A (en) 1959-02-12 1960-12-09 New 18,20-lactones of 20-hydroxy-pregnane-18-acids

Country Status (1)

Country Link
GB (3) GB973143A (en)

Also Published As

Publication number Publication date
GB973145A (en) 1964-10-21
GB973143A (en) 1964-10-21

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