GB941694A - Stable solutions of narcotically-active phenoxyacetic acid amides - Google Patents
Stable solutions of narcotically-active phenoxyacetic acid amidesInfo
- Publication number
- GB941694A GB941694A GB3820662A GB3820662A GB941694A GB 941694 A GB941694 A GB 941694A GB 3820662 A GB3820662 A GB 3820662A GB 3820662 A GB3820662 A GB 3820662A GB 941694 A GB941694 A GB 941694A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- diethylamide
- phenoxyacetic acid
- acid
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AOPRXJXHLWYPQR-UHFFFAOYSA-N 2-phenoxyacetamide Chemical class NC(=O)COC1=CC=CC=C1 AOPRXJXHLWYPQR-UHFFFAOYSA-N 0.000 title abstract 2
- -1 2 - ethoxy Chemical group 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229930006000 Sucrose Natural products 0.000 abstract 2
- 239000011149 active material Substances 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 235000013681 dietary sucrose Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 229960004793 sucrose Drugs 0.000 abstract 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 abstract 1
- FQBPCNCFOCPCJP-UHFFFAOYSA-N 2-(2-methoxy-4-prop-2-enylphenoxy)acetic acid Chemical compound COC1=CC(CC=C)=CC=C1OCC(O)=O FQBPCNCFOCPCJP-UHFFFAOYSA-N 0.000 abstract 1
- DPPINZDLUUCYKL-UHFFFAOYSA-N 2-(4-acetyl-2-ethoxyphenoxy)-N,N-diethylacetamide Chemical compound C(C)N(C(COC1=C(C=C(C=C1)C(C)=O)OCC)=O)CC DPPINZDLUUCYKL-UHFFFAOYSA-N 0.000 abstract 1
- KGCLIEPBSVRBJU-UHFFFAOYSA-N 2-[4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl]acetic acid Chemical compound CCN(CC)C(=O)COC1=CC=C(CC(O)=O)C=C1OC KGCLIEPBSVRBJU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WGIUWMAKFTUYIV-UHFFFAOYSA-N 4-[2-(diethylamino)-2-oxoethoxy]-3-methoxybenzoic acid Chemical compound CCN(CC)C(=O)COC1=CC=C(C(O)=O)C=C1OC WGIUWMAKFTUYIV-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 239000010685 fatty oil Substances 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- RPBKGXGYDGXYGA-UHFFFAOYSA-N n,n-diethyl-2-(2-methoxy-4-prop-1-enylphenoxy)acetamide Chemical compound CCN(CC)C(=O)COC1=CC=C(C=CC)C=C1OC RPBKGXGYDGXYGA-UHFFFAOYSA-N 0.000 abstract 1
- BOORGPJEETYENA-UHFFFAOYSA-N n,n-diethyl-2-(2-methoxy-4-propylphenoxy)acetamide Chemical compound CCCC1=CC=C(OCC(=O)N(CC)CC)C(OC)=C1 BOORGPJEETYENA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229920000151 polyglycol Polymers 0.000 abstract 1
- 239000010695 polyglycol Substances 0.000 abstract 1
- 239000001593 sorbitan monooleate Substances 0.000 abstract 1
- 229940035049 sorbitan monooleate Drugs 0.000 abstract 1
- 235000011069 sorbitan monooleate Nutrition 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
- B65B61/02—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for perforating, scoring, slitting, or applying code or date marks on material prior to packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF35258A DE1182388B (de) | 1961-10-31 | 1961-10-31 | Verfahren zur Herstellung von sterilisierbaren waessrigen Loesungen von narkotisch wirkenden Phenoxyessigsaeureamiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB941694A true GB941694A (en) | 1963-11-13 |
Family
ID=7095928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3820662A Expired GB941694A (en) | 1961-10-31 | 1962-10-09 | Stable solutions of narcotically-active phenoxyacetic acid amides |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE624258A (en, 2012) |
| BR (1) | BR6243886D0 (en, 2012) |
| CH (1) | CH497898A (en, 2012) |
| DE (1) | DE1182388B (en, 2012) |
| GB (1) | GB941694A (en, 2012) |
| NL (2) | NL145144B (en, 2012) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005009420A3 (en) * | 2003-07-23 | 2005-03-03 | Theravance Inc | Pharmaceutical compositions of short-acting sedative hypnotic agent |
| US6887866B2 (en) | 2002-01-25 | 2005-05-03 | Theravance, Inc. | Short-acting sedative hypnotic agents for anesthesia and sedation |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU205010B (en) * | 1987-09-15 | 1992-03-30 | Sandoz Ag | Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US11382909B2 (en) | 2014-09-05 | 2022-07-12 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016196367A1 (en) | 2015-05-29 | 2016-12-08 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1091288B (de) * | 1958-07-03 | 1960-10-20 | Geigy Ag J R | Verfahren zur Herstellung injizierbarer Loesungen von Narkoticis |
| DE1089510B (de) * | 1959-03-23 | 1960-09-22 | Rudolf Reiss Dr | Verfahren zur Herstellung waessriger, injizierbarer Loesungen von 2-Methoxy-4-allylphenoxyessigsaeure-N, N-Diaethylamid |
-
0
- NL NL284933D patent/NL284933A/xx unknown
- BE BE624258D patent/BE624258A/xx unknown
-
1961
- 1961-10-31 DE DEF35258A patent/DE1182388B/de active Pending
-
1962
- 1962-09-28 CH CH1146062A patent/CH497898A/de not_active IP Right Cessation
- 1962-10-09 GB GB3820662A patent/GB941694A/en not_active Expired
- 1962-10-17 BR BR14388662A patent/BR6243886D0/pt unknown
- 1962-10-31 NL NL284933A patent/NL145144B/xx unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887866B2 (en) | 2002-01-25 | 2005-05-03 | Theravance, Inc. | Short-acting sedative hypnotic agents for anesthesia and sedation |
| US7514425B2 (en) | 2002-01-25 | 2009-04-07 | Theravance, Inc. | Short-acting sedative hypnotic agents for anesthesia and sedation |
| US7939689B2 (en) | 2002-01-25 | 2011-05-10 | Theravance, Inc. | Short-acting sedative hypnotic agents for anesthesia and sedation |
| WO2005009420A3 (en) * | 2003-07-23 | 2005-03-03 | Theravance Inc | Pharmaceutical compositions of short-acting sedative hypnotic agent |
| US7790766B2 (en) | 2003-07-23 | 2010-09-07 | Theravance, Inc. | Pharmaceutical compositions of short-acting sedative hypnotic agent |
| US7981931B2 (en) | 2003-07-23 | 2011-07-19 | Theravance, Inc. | Pharmaceutical compositions of short-acting sedative hypnotic agent |
Also Published As
| Publication number | Publication date |
|---|---|
| BR6243886D0 (pt) | 1973-05-29 |
| BE624258A (en, 2012) | |
| NL284933A (en, 2012) | |
| DE1182388B (de) | 1964-11-26 |
| CH497898A (de) | 1970-10-31 |
| NL145144B (nl) | 1975-03-17 |
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