GB931556A - Dibenzocycloheptatriene derivatives - Google Patents
Dibenzocycloheptatriene derivativesInfo
- Publication number
- GB931556A GB931556A GB7308/63A GB730863A GB931556A GB 931556 A GB931556 A GB 931556A GB 7308/63 A GB7308/63 A GB 7308/63A GB 730863 A GB730863 A GB 730863A GB 931556 A GB931556 A GB 931556A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- dihydro
- alkyl
- cycloheptatrien
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QPJORFLSOJAUNL-UHFFFAOYSA-N dibenzo[a,d][7]annulene Chemical class C1=CC2=CC=CC=C2CC2=CC=CC=C21 QPJORFLSOJAUNL-UHFFFAOYSA-N 0.000 title 1
- QVWDCTQRORVHHT-UHFFFAOYSA-N tropone Chemical compound O=C1C=CC=CC=C1 QVWDCTQRORVHHT-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical compound C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000004795 grignard reagents Chemical class 0.000 abstract 2
- 239000011777 magnesium Substances 0.000 abstract 2
- 229910052749 magnesium Inorganic materials 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- HMFNAOVIFKUVFI-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)ethyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CCC1=CC=C(Cl)C=C1 HMFNAOVIFKUVFI-UHFFFAOYSA-N 0.000 abstract 1
- RTFCAFGKEVASCM-UHFFFAOYSA-N 4,5-dimethyl-2-[2-(4-propan-2-ylphenyl)ethyl]benzoic acid Chemical compound C(C)(C)C1=CC=C(C=C1)CCC1=C(C(=O)O)C=C(C(=C1)C)C RTFCAFGKEVASCM-UHFFFAOYSA-N 0.000 abstract 1
- CDPKJZJVTHSESZ-UHFFFAOYSA-N 4-chlorophenylacetic acid Chemical compound OC(=O)CC1=CC=C(Cl)C=C1 CDPKJZJVTHSESZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76380958A | 1958-09-29 | 1958-09-29 | |
| US826493A US3014911A (en) | 1958-09-29 | 1959-07-13 | Derivatives of dibenzo[a, e]cycloheptatriene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB931556A true GB931556A (en) | 1963-07-17 |
Family
ID=27117345
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7308/63A Expired GB931556A (en) | 1958-09-29 | 1959-08-28 | Dibenzocycloheptatriene derivatives |
| GB29490/59A Expired GB931555A (en) | 1958-09-29 | 1959-08-28 | Dibenzocycloheptatriene derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29490/59A Expired GB931555A (en) | 1958-09-29 | 1959-08-28 | Dibenzocycloheptatriene derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3014911A (enrdf_load_stackoverflow) |
| BE (1) | BE582220A (enrdf_load_stackoverflow) |
| CH (1) | CH387037A (enrdf_load_stackoverflow) |
| DE (1) | DE1420072C3 (enrdf_load_stackoverflow) |
| FR (1) | FR490M (enrdf_load_stackoverflow) |
| GB (2) | GB931556A (enrdf_load_stackoverflow) |
| MY (1) | MY6400051A (enrdf_load_stackoverflow) |
| OA (1) | OA00998A (enrdf_load_stackoverflow) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL237664A (enrdf_load_stackoverflow) * | 1959-04-01 | |||
| GB999879A (en) * | 1960-11-09 | 1965-07-28 | Sandoz Ag | Improvements in or relating to dibenzocycloheptane derivatives |
| NL122808C (enrdf_load_stackoverflow) * | 1961-09-29 | |||
| BE626236A (enrdf_load_stackoverflow) * | 1961-12-18 | |||
| US3133935A (en) * | 1962-01-08 | 1964-05-19 | American Home Prod | Dibenzo [a, d] [1, 4] cyclooctadienes |
| US3231468A (en) * | 1962-07-02 | 1966-01-25 | Merck & Co Inc | Dexamethasone-cyproheptadine oral antiflammatory compositions |
| NL297097A (enrdf_load_stackoverflow) * | 1962-08-31 | |||
| US3152135A (en) * | 1962-11-02 | 1964-10-06 | Warner Lambert Pharmaceutical | Heterocyclic substituted indazole compounds and process therefor |
| US3419565A (en) * | 1963-04-24 | 1968-12-31 | Schering Corp | Aza-dibenzocycloheptenes |
| NL132137C (enrdf_load_stackoverflow) * | 1963-04-24 | |||
| US3324138A (en) * | 1963-12-03 | 1967-06-06 | Koninklijke Pharma Fab Nv | Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid |
| US3491103A (en) * | 1963-12-19 | 1970-01-20 | Sandoz Ag | Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes |
| US3420848A (en) * | 1964-05-18 | 1969-01-07 | Sandoz Ag | Dibenzocycloheptane derivatives |
| GB1091910A (en) * | 1964-08-18 | 1967-11-22 | Koninklijke Pharma Fab Nv | New dibenzocycloheptenylamines |
| GB1127683A (en) * | 1965-03-15 | 1968-09-18 | Merck & Co Inc | Anthelmintic compositions |
| US3484520A (en) * | 1965-05-17 | 1969-12-16 | Merck & Co Inc | Compositions and methods for treating helminthiasis comprising combinations of organo-phosphates and certain dibenzocycloheptenes |
| US3352869A (en) * | 1965-05-18 | 1967-11-14 | Merck & Co Inc | Substituted and unsubstituted 4-(5h-dibenzo[a, d] cyclohepten-5-ylidene)-1-(amino ornitroso) piperidines |
| US3391143A (en) * | 1966-05-16 | 1968-07-02 | Smith Kline French Lab | 9-piperidyl and 9-piperidylidene derivatives of acridan |
| US3919321A (en) * | 1966-11-08 | 1975-11-11 | Hoffmann La Roche | Halo-substituted-5H-dibenzo{8 a,d{9 cyclohepten-5-ones |
| US3458522A (en) * | 1967-05-17 | 1969-07-29 | Sandoz Ag | 4-piperidine substituted benzocycloheptaoxazoles and benzocycloheptathiazoles |
| US3475438A (en) * | 1967-08-24 | 1969-10-28 | Merck & Co Inc | Piperidine derivatives of dibenzobicyclo(5.1.0)octane |
| GB1273823A (en) * | 1968-10-22 | 1972-05-10 | Soc Ind Fab Antibiotiques Sifa | New tropane derivatives their salts and process for preparation thereof |
| US3968115A (en) * | 1970-02-05 | 1976-07-06 | Merck & Co., Inc. | 1-Alkyl-4-(10 and/or 11)-bromo-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-ylidene piperidine compounds |
| US3981876A (en) * | 1970-02-05 | 1976-09-21 | Merck & Co., Inc. | 1-Alkyl-4-(10[1-piperidyl]-5H-dibenzo-[a,d]cyclohepten-5-ylidene)piperidine compounds |
| US3960872A (en) * | 1970-02-05 | 1976-06-01 | Merck & Co., Inc. | 1 Alkyl-4-(10:oxo or hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compounds |
| US3988342A (en) * | 1972-08-14 | 1976-10-26 | Merck & Co., Inc. | Piperidylidene derivatives of cyano-5H-dibenzo[a,d]cycloheptene |
| US3981877A (en) * | 1972-08-14 | 1976-09-21 | Merck & Co., Inc. | Piperidylidene derivatives of carboxy-5H-dibenzo[a,d]cycloheptene |
| US4072756A (en) * | 1973-05-17 | 1978-02-07 | Sandoz Ltd. | Tricyclo piperidino ketones and soporific compositions thereof |
| US3965181A (en) | 1973-07-06 | 1976-06-22 | Syntex (U.S.A.) Inc. | Tricyclic pharmacological agents, intermediates and methods of making |
| GB1435054A (en) * | 1974-02-04 | 1976-05-12 | Ici Ltd | Dihydroanthracene derivatives |
| US4089864A (en) * | 1974-03-25 | 1978-05-16 | Merck & Co., Inc. | 4-(10,11-Dihydro-cis and trans-10,11-dihydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidines |
| US3974285A (en) * | 1974-04-10 | 1976-08-10 | Merck & Co., Inc. | 10,11-Furo-derivatives of cyproheptadine |
| HU169186B (enrdf_load_stackoverflow) * | 1974-06-13 | 1976-10-28 | ||
| US3992547A (en) * | 1974-11-20 | 1976-11-16 | Merck & Co., Inc. | 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine-N-oxide isomer |
| US4044143A (en) * | 1975-01-30 | 1977-08-23 | Merck & Co., Inc. | 10,11-Bis-(hydroxyalkyl) derivatives of cyproheptadine |
| US4160031A (en) * | 1975-03-28 | 1979-07-03 | Merck & Co., Inc. | Antihistaminic and appetite stimulating 10,11-dihydro-3-carboxycyproheptadine |
| US4022902A (en) * | 1975-08-29 | 1977-05-10 | Merck & Co., Inc. | 10,11-Dihydro-3-carboxycyproheptadien-N-oxide |
| US4112112A (en) * | 1976-06-29 | 1978-09-05 | Merck & Co., Inc. | Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect |
| US4104398A (en) * | 1976-08-12 | 1978-08-01 | Merck & Co., Inc. | 3-Lower alkoxycyproheptadines as serotonin inhibitors |
| US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
| US4132796A (en) * | 1977-12-01 | 1979-01-02 | Merck & Co., Inc. | Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine |
| US4195091A (en) * | 1978-11-15 | 1980-03-25 | Merck & Co., Inc. | Appetite stimulating pyrrolo[2,1-b][3]benzazepines |
| ATE3150T1 (de) * | 1979-01-02 | 1983-05-15 | Merck & Co. Inc. | Links- und rechtsdrehende enantiomere von 3halocyproheptadinen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzung. |
| US4212871A (en) * | 1979-03-02 | 1980-07-15 | Merck & Co., Inc. | Appetite stimulating and antihistaminic 3-hydroxymethylcyproheptadine and analogs |
| EP0019797A1 (en) * | 1979-05-21 | 1980-12-10 | Merck & Co. Inc. | Levorotatory and dextrorotatory enantiomers of 3-methoxycyproheptadine and analogs thereof, process for their preparation and antipsychotic pharmaceutical compositions |
| US4220651A (en) * | 1979-05-21 | 1980-09-02 | Merck & Co., Inc. | Antipsychotic levorotatory enantiomers of 3-halocyproheptadines, analogs and derivatives |
| US4275070A (en) * | 1979-05-21 | 1981-06-23 | Merck & Co., Inc. | Antipsychotic pharmaceutical compositions of the levorotatory enantiomers of 3-methoxycyproheptadine and an analog thereof |
| US4356184A (en) * | 1980-06-04 | 1982-10-26 | G. D. Searle & Co. | Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines |
| US4412999A (en) * | 1982-04-14 | 1983-11-01 | Merck & Co., Inc. | Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds |
| US4590202A (en) * | 1984-01-19 | 1986-05-20 | Merck & Co., Inc. | N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine compounds and α2 -adrenergic antagonistic uses thereof |
| US4626542A (en) * | 1984-04-05 | 1986-12-02 | Merck & Co., Inc. | 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods |
| US4758577A (en) * | 1984-04-05 | 1988-07-19 | Merck & Co., Inc. | 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders |
| FR2618151B1 (fr) * | 1987-07-16 | 1991-01-11 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique |
| US5250681A (en) * | 1988-06-02 | 1993-10-05 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US4912222A (en) * | 1988-06-17 | 1990-03-27 | Fisons Corporation | Antihistamines related to cyproheptadine |
| EP0347123A3 (en) * | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| CA2004211A1 (en) * | 1988-11-30 | 1990-05-31 | Masataka Syoji | Piperidine derivatives and hyportensives containing the same |
| US5021426A (en) * | 1990-02-26 | 1991-06-04 | Merck & Co., Inc. | Method of traeting malaria with cyproheptadine derivatives |
| SE509618C2 (sv) | 1997-03-06 | 1999-02-15 | Goeran Blomqvist | Farmaceutisk komposition för behandling av s k restless legs |
| US6880501B2 (en) | 2001-07-30 | 2005-04-19 | Massachusetts Institute Of Technology | Internal combustion engine |
| US10398687B2 (en) | 2010-09-14 | 2019-09-03 | David Reed Helton | Use of cyproheptadine to treat organophosphate exposure |
| CN110407737B (zh) * | 2019-07-30 | 2021-03-23 | 广州普星药业有限公司 | 一种盐酸赛庚啶的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA535142A (en) * | 1957-01-01 | W. Weston Arthur | Pipecolyl carbinol compounds | |
| DE925468C (de) * | 1941-08-13 | 1955-03-21 | Hoechst Ag | Verfahren zur Herstellung von ª†, ª†-Diaryl-propyl-aminen |
| US2498431A (en) * | 1945-06-13 | 1950-02-21 | Hoffmann La Roche | 2-and 4-homocyclyl substituted piperidines |
| US2599364A (en) * | 1949-01-26 | 1952-06-03 | Hoffmann La Roche | 1-alkyl-3-benzohydryl piperidines |
| NL88063C (enrdf_load_stackoverflow) * | 1950-12-05 | |||
| US2985660A (en) * | 1960-04-29 | 1961-05-23 | Lakeside Lab Inc | 5-heterocyclic-5h-dibenzo [a, d] cycloheptenes |
-
1959
- 1959-07-13 US US826493A patent/US3014911A/en not_active Expired - Lifetime
- 1959-08-28 GB GB7308/63A patent/GB931556A/en not_active Expired
- 1959-08-28 GB GB29490/59A patent/GB931555A/en not_active Expired
- 1959-09-01 BE BE582220A patent/BE582220A/fr unknown
- 1959-09-03 DE DE1420072A patent/DE1420072C3/de not_active Expired
- 1959-09-29 CH CH7878959A patent/CH387037A/de unknown
-
1960
- 1960-08-30 FR FR837257A patent/FR490M/fr active Active
-
1964
- 1964-12-29 OA OA51101A patent/OA00998A/xx unknown
- 1964-12-30 MY MY51/64A patent/MY6400051A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB931555A (en) | 1963-07-17 |
| DE1420072C3 (de) | 1974-08-08 |
| BE582220A (fr) | 1960-03-01 |
| OA00998A (fr) | 1968-08-07 |
| DE1420072A1 (de) | 1968-10-03 |
| DE1420072B2 (de) | 1974-01-03 |
| MY6400051A (en) | 1964-12-31 |
| US3014911A (en) | 1961-12-26 |
| CH387037A (de) | 1965-01-31 |
| FR490M (enrdf_load_stackoverflow) | 1961-05-08 |
Similar Documents
| Publication | Publication Date | Title |
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| GB931556A (en) | Dibenzocycloheptatriene derivatives | |
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