CH387037A - Verfahren zur Herstellung von Dibenzo(a,e)cycloheptatrien-Derivaten - Google Patents

Verfahren zur Herstellung von Dibenzo(a,e)cycloheptatrien-Derivaten

Info

Publication number
CH387037A
CH387037A CH7878959A CH7878959A CH387037A CH 387037 A CH387037 A CH 387037A CH 7878959 A CH7878959 A CH 7878959A CH 7878959 A CH7878959 A CH 7878959A CH 387037 A CH387037 A CH 387037A
Authority
CH
Switzerland
Prior art keywords
dibenzo
preparation
cycloheptatriene
derivatives
cycloheptatriene derivatives
Prior art date
Application number
CH7878959A
Other languages
English (en)
Inventor
Louis Engelhardt Edward
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27117345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CH387037(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH387037A publication Critical patent/CH387037A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CH7878959A 1958-09-29 1959-09-29 Verfahren zur Herstellung von Dibenzo(a,e)cycloheptatrien-Derivaten CH387037A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380958A 1958-09-29 1958-09-29
US826493A US3014911A (en) 1958-09-29 1959-07-13 Derivatives of dibenzo[a, e]cycloheptatriene

Publications (1)

Publication Number Publication Date
CH387037A true CH387037A (de) 1965-01-31

Family

ID=27117345

Family Applications (1)

Application Number Title Priority Date Filing Date
CH7878959A CH387037A (de) 1958-09-29 1959-09-29 Verfahren zur Herstellung von Dibenzo(a,e)cycloheptatrien-Derivaten

Country Status (8)

Country Link
US (1) US3014911A (de)
BE (1) BE582220A (de)
CH (1) CH387037A (de)
DE (1) DE1420072C3 (de)
FR (1) FR490M (de)
GB (2) GB931555A (de)
MY (1) MY6400051A (de)
OA (1) OA00998A (de)

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NL237664A (de) * 1959-04-01
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NL122808C (de) * 1961-09-29
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US3133935A (en) * 1962-01-08 1964-05-19 American Home Prod Dibenzo [a, d] [1, 4] cyclooctadienes
US3231468A (en) * 1962-07-02 1966-01-25 Merck & Co Inc Dexamethasone-cyproheptadine oral antiflammatory compositions
NL130095C (de) * 1962-08-31
US3152135A (en) * 1962-11-02 1964-10-06 Warner Lambert Pharmaceutical Heterocyclic substituted indazole compounds and process therefor
US3419565A (en) * 1963-04-24 1968-12-31 Schering Corp Aza-dibenzocycloheptenes
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US3324138A (en) * 1963-12-03 1967-06-06 Koninklijke Pharma Fab Nv Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3420848A (en) * 1964-05-18 1969-01-07 Sandoz Ag Dibenzocycloheptane derivatives
GB1091910A (en) * 1964-08-18 1967-11-22 Koninklijke Pharma Fab Nv New dibenzocycloheptenylamines
GB1127683A (en) * 1965-03-15 1968-09-18 Merck & Co Inc Anthelmintic compositions
US3484520A (en) * 1965-05-17 1969-12-16 Merck & Co Inc Compositions and methods for treating helminthiasis comprising combinations of organo-phosphates and certain dibenzocycloheptenes
US3352869A (en) * 1965-05-18 1967-11-14 Merck & Co Inc Substituted and unsubstituted 4-(5h-dibenzo[a, d] cyclohepten-5-ylidene)-1-(amino ornitroso) piperidines
US3391143A (en) * 1966-05-16 1968-07-02 Smith Kline French Lab 9-piperidyl and 9-piperidylidene derivatives of acridan
US3919321A (en) * 1966-11-08 1975-11-11 Hoffmann La Roche Halo-substituted-5H-dibenzo{8 a,d{9 cyclohepten-5-ones
US3458522A (en) * 1967-05-17 1969-07-29 Sandoz Ag 4-piperidine substituted benzocycloheptaoxazoles and benzocycloheptathiazoles
US3475438A (en) * 1967-08-24 1969-10-28 Merck & Co Inc Piperidine derivatives of dibenzobicyclo(5.1.0)octane
GB1273823A (en) * 1968-10-22 1972-05-10 Soc Ind Fab Antibiotiques Sifa New tropane derivatives their salts and process for preparation thereof
US3981876A (en) * 1970-02-05 1976-09-21 Merck & Co., Inc. 1-Alkyl-4-(10[1-piperidyl]-5H-dibenzo-[a,d]cyclohepten-5-ylidene)piperidine compounds
US3968115A (en) * 1970-02-05 1976-07-06 Merck & Co., Inc. 1-Alkyl-4-(10 and/or 11)-bromo-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-ylidene piperidine compounds
US3960872A (en) * 1970-02-05 1976-06-01 Merck & Co., Inc. 1 Alkyl-4-(10:oxo or hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compounds
US3981877A (en) * 1972-08-14 1976-09-21 Merck & Co., Inc. Piperidylidene derivatives of carboxy-5H-dibenzo[a,d]cycloheptene
US3988342A (en) * 1972-08-14 1976-10-26 Merck & Co., Inc. Piperidylidene derivatives of cyano-5H-dibenzo[a,d]cycloheptene
US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
GB1435054A (en) * 1974-02-04 1976-05-12 Ici Ltd Dihydroanthracene derivatives
US4089864A (en) * 1974-03-25 1978-05-16 Merck & Co., Inc. 4-(10,11-Dihydro-cis and trans-10,11-dihydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidines
US3974285A (en) * 1974-04-10 1976-08-10 Merck & Co., Inc. 10,11-Furo-derivatives of cyproheptadine
HU169186B (de) * 1974-06-13 1976-10-28
US3992547A (en) * 1974-11-20 1976-11-16 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine-N-oxide isomer
US4044143A (en) * 1975-01-30 1977-08-23 Merck & Co., Inc. 10,11-Bis-(hydroxyalkyl) derivatives of cyproheptadine
US4160031A (en) * 1975-03-28 1979-07-03 Merck & Co., Inc. Antihistaminic and appetite stimulating 10,11-dihydro-3-carboxycyproheptadine
US4022902A (en) * 1975-08-29 1977-05-10 Merck & Co., Inc. 10,11-Dihydro-3-carboxycyproheptadien-N-oxide
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
US4104398A (en) * 1976-08-12 1978-08-01 Merck & Co., Inc. 3-Lower alkoxycyproheptadines as serotonin inhibitors
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
US4132796A (en) * 1977-12-01 1979-01-02 Merck & Co., Inc. Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine
US4195091A (en) * 1978-11-15 1980-03-25 Merck & Co., Inc. Appetite stimulating pyrrolo[2,1-b][3]benzazepines
EP0012988B1 (de) * 1979-01-02 1983-04-27 Merck & Co. Inc. Links- und rechtsdrehende Enantiomere von 3-Halocyproheptadinen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzung
US4212871A (en) * 1979-03-02 1980-07-15 Merck & Co., Inc. Appetite stimulating and antihistaminic 3-hydroxymethylcyproheptadine and analogs
EP0019797A1 (de) * 1979-05-21 1980-12-10 Merck & Co. Inc. Links- und rechtsdrehende Enantiomere von 3-Methoxycyproheptadin und ihre Analoge, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antipsychotischer Wirkung
US4220651A (en) * 1979-05-21 1980-09-02 Merck & Co., Inc. Antipsychotic levorotatory enantiomers of 3-halocyproheptadines, analogs and derivatives
US4275070A (en) * 1979-05-21 1981-06-23 Merck & Co., Inc. Antipsychotic pharmaceutical compositions of the levorotatory enantiomers of 3-methoxycyproheptadine and an analog thereof
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4412999A (en) * 1982-04-14 1983-11-01 Merck & Co., Inc. Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
US4590202A (en) * 1984-01-19 1986-05-20 Merck & Co., Inc. N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine compounds and α2 -adrenergic antagonistic uses thereof
US4626542A (en) * 1984-04-05 1986-12-02 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods
US4758577A (en) * 1984-04-05 1988-07-19 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders
FR2618151B1 (fr) * 1987-07-16 1991-01-11 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
EP0347123A3 (de) * 1988-06-17 1991-07-03 Fisons Corporation Dibenzo-cycloheptenyl-, -cycloheptyl- und -oxepinylamine mit antihistaminischer Aktivität
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
US5021426A (en) * 1990-02-26 1991-06-04 Merck & Co., Inc. Method of traeting malaria with cyproheptadine derivatives
SE509618C2 (sv) 1997-03-06 1999-02-15 Goeran Blomqvist Farmaceutisk komposition för behandling av s k restless legs
US6880501B2 (en) 2001-07-30 2005-04-19 Massachusetts Institute Of Technology Internal combustion engine
US10398687B2 (en) 2010-09-14 2019-09-03 David Reed Helton Use of cyproheptadine to treat organophosphate exposure
CN110407737B (zh) * 2019-07-30 2021-03-23 广州普星药业有限公司 一种盐酸赛庚啶的制备方法

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Also Published As

Publication number Publication date
OA00998A (fr) 1968-08-07
FR490M (de) 1961-05-08
GB931556A (en) 1963-07-17
MY6400051A (en) 1964-12-31
DE1420072C3 (de) 1974-08-08
US3014911A (en) 1961-12-26
BE582220A (fr) 1960-03-01
DE1420072A1 (de) 1968-10-03
GB931555A (en) 1963-07-17
DE1420072B2 (de) 1974-01-03

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