MY6400051A - Dibenxocyclohepatriene derivatives - Google Patents

Dibenxocyclohepatriene derivatives

Info

Publication number
MY6400051A
MY6400051A MY51/64A MY6400051A MY6400051A MY 6400051 A MY6400051 A MY 6400051A MY 51/64 A MY51/64 A MY 51/64A MY 6400051 A MY6400051 A MY 6400051A MY 6400051 A MY6400051 A MY 6400051A
Authority
MY
Malaysia
Prior art keywords
dibenxocyclohepatriene
derivatives
Prior art date
Application number
MY51/64A
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US76380958A priority Critical
Priority to US826493A priority patent/US3014911A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MY6400051A publication Critical patent/MY6400051A/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27117345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY6400051(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms
MY51/64A 1958-09-29 1964-12-30 Dibenxocyclohepatriene derivatives MY6400051A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US76380958A true 1958-09-29 1958-09-29
US826493A US3014911A (en) 1958-09-29 1959-07-13 Derivatives of dibenzo[a, e]cycloheptatriene

Publications (1)

Publication Number Publication Date
MY6400051A true MY6400051A (en) 1964-12-31

Family

ID=27117345

Family Applications (1)

Application Number Title Priority Date Filing Date
MY51/64A MY6400051A (en) 1958-09-29 1964-12-30 Dibenxocyclohepatriene derivatives

Country Status (7)

Country Link
US (1) US3014911A (en)
BE (1) BE582220A (en)
CH (1) CH387037A (en)
DE (1) DE1420072C3 (en)
GB (2) GB931556A (en)
MY (1) MY6400051A (en)
OA (1) OA998A (en)

Families Citing this family (60)

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NL237664A (en) * 1959-04-01
GB999879A (en) * 1960-11-09 1965-07-28 Sandoz Ag Improvements in or relating to dibenzocycloheptane derivatives
FR2959M (en) * 1961-09-29 Merck & Co Inc New antihistamine drugs based on thiaxanthene derivatives.
BE626236A (en) * 1961-12-18
US3133935A (en) * 1962-01-08 1964-05-19 American Home Prod Dibenzo [a, d] [1, 4] cyclooctadienes
US3231468A (en) * 1962-07-02 1966-01-25 Merck & Co Inc Dexamethasone-cyproheptadine oral antiflammatory compositions
FR3074M (en) * 1962-08-31 Sandoz Sa Drug based on a new heterocyclic derivative of benzocycloheptane.
US3152135A (en) * 1962-11-02 1964-10-06 Warner Lambert Pharmaceutical Heterocyclic substituted indazole compounds and process therefor
NL132137C (en) * 1963-04-24
US3419565A (en) * 1963-04-24 1968-12-31 Schering Corp Aza-dibenzocycloheptenes
US3324138A (en) * 1963-12-03 1967-06-06 Koninklijke Pharma Fab Nv Quinuclidin-3-yl-ester of 10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-5-yl-acetic acid
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3420848A (en) * 1964-05-18 1969-01-07 Sandoz Ag Dibenzocycloheptane derivatives
FR4520M (en) * 1964-08-18
GB1127683A (en) * 1965-03-15 1968-09-18 Merck & Co Inc Anthelmintic compositions
US3484520A (en) * 1965-05-17 1969-12-16 Merck & Co Inc Compositions and methods for treating helminthiasis comprising combinations of organo-phosphates and certain dibenzocycloheptenes
US3352869A (en) * 1965-05-18 1967-11-14 Merck & Co Inc Substituted and unsubstituted 4-(5h-dibenzo[a, d] cyclohepten-5-ylidene)-1-(amino ornitroso) piperidines
US3391143A (en) * 1966-05-16 1968-07-02 Smith Kline French Lab 9-piperidyl and 9-piperidylidene derivatives of acridan
US3919321A (en) * 1966-11-08 1975-11-11 Hoffmann La Roche Halo-substituted-5H-dibenzo{8 a,d{9 cyclohepten-5-ones
US3458522A (en) * 1967-05-17 1969-07-29 Sandoz Ag 4-piperidine substituted benzocycloheptaoxazoles and benzocycloheptathiazoles
US3475438A (en) * 1967-08-24 1969-10-28 Merck & Co Inc Piperidine derivatives of dibenzobicyclo(5.1.0)octane
GB1273823A (en) * 1968-10-22 1972-05-10 Soc Ind Fab Antibiotiques Sifa New tropane derivatives their salts and process for preparation thereof
US3968115A (en) * 1970-02-05 1976-07-06 Merck & Co., Inc. 1-Alkyl-4-(10 and/or 11)-bromo-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-ylidene piperidine compounds
US3960872A (en) * 1970-02-05 1976-06-01 Merck & Co., Inc. 1 Alkyl-4-(10:oxo or hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compounds
US3981876A (en) * 1970-02-05 1976-09-21 Merck & Co., Inc. 1-Alkyl-4-(10[1-piperidyl]-5H-dibenzo-[a,d]cyclohepten-5-ylidene)piperidine compounds
US3981877A (en) * 1972-08-14 1976-09-21 Merck & Co., Inc. Piperidylidene derivatives of carboxy-5H-dibenzo[a,d]cycloheptene
US3988342A (en) * 1972-08-14 1976-10-26 Merck & Co., Inc. Piperidylidene derivatives of cyano-5H-dibenzo[a,d]cycloheptene
US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
GB1435054A (en) * 1974-02-04 1976-05-12 Ici Ltd Dihydroanthracene derivatives
US4089864A (en) * 1974-03-25 1978-05-16 Merck & Co., Inc. 4-(10,11-Dihydro-cis and trans-10,11-dihydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidines
US4044143A (en) * 1975-01-30 1977-08-23 Merck & Co., Inc. 10,11-Bis-(hydroxyalkyl) derivatives of cyproheptadine
US3974285A (en) * 1974-04-10 1976-08-10 Merck & Co., Inc. 10,11-Furo-derivatives of cyproheptadine
HU169186B (en) * 1974-06-13 1976-10-28
US3992547A (en) * 1974-11-20 1976-11-16 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine-N-oxide isomer
US4160031A (en) * 1975-03-28 1979-07-03 Merck & Co., Inc. Antihistaminic and appetite stimulating 10,11-dihydro-3-carboxycyproheptadine
US4022902A (en) * 1975-08-29 1977-05-10 Merck & Co., Inc. 10,11-Dihydro-3-carboxycyproheptadien-N-oxide
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
US4104398A (en) * 1976-08-12 1978-08-01 Merck & Co., Inc. 3-Lower alkoxycyproheptadines as serotonin inhibitors
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
US4132796A (en) * 1977-12-01 1979-01-02 Merck & Co., Inc. Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine
US4195091A (en) * 1978-11-15 1980-03-25 Merck & Co., Inc. Appetite stimulating pyrrolo[2,1-b][3]benzazepines
EP0012988B1 (en) * 1979-01-02 1983-04-27 Merck & Co. Inc. Levorotatory or dextrorotatory enantiomers of 3-halocyproheptadines, process for their preparation and pharmaceutical composition thereof
US4212871A (en) * 1979-03-02 1980-07-15 Merck & Co., Inc. Appetite stimulating and antihistaminic 3-hydroxymethylcyproheptadine and analogs
US4220651A (en) * 1979-05-21 1980-09-02 Merck & Co., Inc. Antipsychotic levorotatory enantiomers of 3-halocyproheptadines, analogs and derivatives
US4275070A (en) * 1979-05-21 1981-06-23 Merck & Co., Inc. Antipsychotic pharmaceutical compositions of the levorotatory enantiomers of 3-methoxycyproheptadine and an analog thereof
EP0019797A1 (en) * 1979-05-21 1980-12-10 Merck & Co. Inc. Levorotatory and dextrorotatory enantiomers of 3-methoxycyproheptadine and analogs thereof, process for their preparation and antipsychotic pharmaceutical compositions
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4412999A (en) * 1982-04-14 1983-11-01 Merck & Co., Inc. Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
US4590202A (en) * 1984-01-19 1986-05-20 Merck & Co., Inc. N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine compounds and α2 -adrenergic antagonistic uses thereof
US4626542A (en) * 1984-04-05 1986-12-02 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods
US4758577A (en) * 1984-04-05 1988-07-19 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
FR2618151B1 (en) * 1987-07-16 1991-01-11 Synthelabo Piperidine derivatives, their preparation and their therapeutic application
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
EP0347123A3 (en) * 1988-06-17 1991-07-03 Fisons Corporation Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
US5021426A (en) * 1990-02-26 1991-06-04 Merck & Co., Inc. Method of traeting malaria with cyproheptadine derivatives
SE509618C2 (en) 1997-03-06 1999-02-15 Goeran Blomqvist Pharmaceutical composition for the treatment of so-called restless legs
US10398687B2 (en) 2010-09-14 2019-09-03 David Reed Helton Use of cyproheptadine to treat organophosphate exposure
CN110407737B (en) * 2019-07-30 2021-03-23 广州普星药业有限公司 Preparation method of cyproheptadine hydrochloride

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CA535142A (en) * 1957-01-01 W. Weston Arthur Pipecolyl carbinol compounds
DE925468C (en) * 1941-08-13 1955-03-21 Hoechst Ag Process for the preparation of ª †, ª † -Diaryl-propyl-amines
US2498431A (en) * 1945-06-13 1950-02-21 Hoffmann La Roche 2-and 4-homocyclyl substituted piperidines
US2599364A (en) * 1949-01-26 1952-06-03 Hoffmann La Roche 1-alkyl-3-benzohydryl piperidines
NL88063C (en) * 1950-12-05
US2985660A (en) * 1960-04-29 1961-05-23 Lakeside Lab Inc 5-heterocyclic-5h-dibenzo [a, d] cycloheptenes

Also Published As

Publication number Publication date
BE582220A (en) 1960-03-01
OA998A (en) 1968-08-07
US3014911A (en) 1961-12-26
DE1420072A1 (en) 1968-10-03
OA00998A (en) 1968-08-07
GB931556A (en) 1963-07-17
DE1420072B2 (en) 1974-01-03
GB931555A (en) 1963-07-17
BE582220A1 (en)
DE1420072C3 (en) 1974-08-08
CH387037A (en) 1965-01-31

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