GB927666A - Process for the manufacture of a sulphur-containing derivative of vitamin b - Google Patents
Process for the manufacture of a sulphur-containing derivative of vitamin bInfo
- Publication number
- GB927666A GB927666A GB2961461A GB2961461A GB927666A GB 927666 A GB927666 A GB 927666A GB 2961461 A GB2961461 A GB 2961461A GB 2961461 A GB2961461 A GB 2961461A GB 927666 A GB927666 A GB 927666A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- disulphide
- hydroxy
- water
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Bis-[4-hydroxy-methyl-5-hydroxy-6-methyl-pyridyl-(3) -methyl]-disulphide is obtained by reacting an acid addition salt of 3,4-bis-bromo-methyl-5-hydroxy-6-methyl-pyridine or 3-bromomethyl-4-hydroxymethyl-5-hydroxy-6-methyl-pyridine in the presence of water and/or a water miscible organic solvent with a water-soluble inorganic disulphide preferably sodium disulphide. The dibromide is preferably heated in aqueous solution to 5070 DEG C. for about 15 minutes and then added drop by drop to sodium disulphide at room temperature; the required disulphide precipitating from the reaction mixture. Specified water miscible solvents are methanol, ethanol, isopropanol, acetone, dioxane, tetrahydrofuran, dimethyl formamide, glycerol and glycol. The disulphide is washed with acetone or methanol and then dried and recrystallised from butanol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM0004639 | 1960-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB927666A true GB927666A (en) | 1963-05-29 |
Family
ID=7292784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2961461A Expired GB927666A (en) | 1960-08-27 | 1961-08-16 | Process for the manufacture of a sulphur-containing derivative of vitamin b |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB927666A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2466728C1 (en) * | 2011-09-12 | 2012-11-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Phosphonium salts on basis of pyridoxine derivatives |
-
1961
- 1961-08-16 GB GB2961461A patent/GB927666A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2466728C1 (en) * | 2011-09-12 | 2012-11-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) | Phosphonium salts on basis of pyridoxine derivatives |
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