GB930302A - A process for preparing thiamine derivatives - Google Patents
A process for preparing thiamine derivativesInfo
- Publication number
- GB930302A GB930302A GB8615/61A GB861561A GB930302A GB 930302 A GB930302 A GB 930302A GB 8615/61 A GB8615/61 A GB 8615/61A GB 861561 A GB861561 A GB 861561A GB 930302 A GB930302 A GB 930302A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiosulphate
- sodium
- ethanol
- methyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds having the general formula:- <FORM:0930302/IV(a)/1> wherein R is hydrogen or halogen or methyl or a nitro radical are prepared by reacting thiamine hydrochloride with compounds having the formula <FORM:0930302/IV(a)/2> wherein R has the same meaning as above. Reaction is preferably effected at a temperature of 0-30 DEG C. and at a pH of 7-8, in water or an aqueous organic solvent such as aqueous methanol, ethanol, acetone or dioxane. In examples thiamine hydrochloride is reacted with (Ex 1) sodium p-chlorobenzoyl thiosulphate; (Ex 2) sodium p-methylbenzoyl thiosulphate; (Ex 3) sodium benzoyl-thiosulphate; or (Ex 4) sodium p nitrobenzoyl thiosulphate to give the corresponding S-benzoylthiamine. The thiosulphates may be prepared by adding dropwise benzoyl chloride or the corresponding p-chloro-, p-methyl- or p-nitro derivative to a mixture of sodium thiosulphate, water and ethanol and allowing the mixture to crystallise. Specification 741,250 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP778760 | 1960-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB930302A true GB930302A (en) | 1963-07-03 |
Family
ID=11675361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8615/61A Expired GB930302A (en) | 1960-03-14 | 1961-03-09 | A process for preparing thiamine derivatives |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH392518A (en) |
| GB (1) | GB930302A (en) |
-
1961
- 1961-03-09 GB GB8615/61A patent/GB930302A/en not_active Expired
- 1961-03-10 CH CH290361A patent/CH392518A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH392518A (en) | 1965-05-31 |
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