GB888415A - Production of an intermediate for the synthesis of reserpine - Google Patents

Production of an intermediate for the synthesis of reserpine

Info

Publication number
GB888415A
GB888415A GB16721/58A GB1672158A GB888415A GB 888415 A GB888415 A GB 888415A GB 16721/58 A GB16721/58 A GB 16721/58A GB 1672158 A GB1672158 A GB 1672158A GB 888415 A GB888415 A GB 888415A
Authority
GB
United Kingdom
Prior art keywords
acid
methylene chloride
reserpine
hydroxy
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16721/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB888415A publication Critical patent/GB888415A/en
Expired legal-status Critical Current

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Abstract

Laevo - rotatory lactone of 6a - bromo - 8b - hydroxy - 2a - methoxy - 3b ,5b - epoxy - 7 - oxo - 4aa , - 8aa - decahydronaphthalene - 1b - carb - oxylic acid or its optical antipode or racemate is prepared according to the equation <FORM:0888415/IV (b)/1> <FORM:0888415/IV (b)/2> by oxidising the corresponding 7b -hydroxy compound with a solution of chromic acid and phosphoric acid in aqueous acetic acid, working at ambient temperature and in the presence of a solvent which is immiscible with water, e.g. dichloroethane, tetrachloroethane, or methylene chloride, and subsequently separating the desired product, e.g. by extraction with methylene chloride. A detailed example is given. Specifications 868,475, 868,477, 868,478, 868,484 868,485, 888,407, 888,408, 888,409, 888,410, 888,411, 888,412, 888,413, 888,414 and 888,416 are referred to.
GB16721/58A 1957-06-17 1958-05-23 Production of an intermediate for the synthesis of reserpine Expired GB888415A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR888415X 1957-06-17

Publications (1)

Publication Number Publication Date
GB888415A true GB888415A (en) 1962-01-31

Family

ID=9376770

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16721/58A Expired GB888415A (en) 1957-06-17 1958-05-23 Production of an intermediate for the synthesis of reserpine

Country Status (1)

Country Link
GB (1) GB888415A (en)

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