GB893921A - Improvements in or relating to steroids and the manufacture thereof - Google Patents

Improvements in or relating to steroids and the manufacture thereof

Info

Publication number
GB893921A
GB893921A GB14614/60A GB1461460A GB893921A GB 893921 A GB893921 A GB 893921A GB 14614/60 A GB14614/60 A GB 14614/60A GB 1461460 A GB1461460 A GB 1461460A GB 893921 A GB893921 A GB 893921A
Authority
GB
United Kingdom
Prior art keywords
compound
lower alkyl
carbon atoms
formula
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14614/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB893921A publication Critical patent/GB893921A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a compound having the formula <FORM:0893921/IV (b)/1> wherein R is fluorine or lower alkyl (1-8 carbon atoms) and R1 is lower alkylene (2-3 carbon atoms) and a process for the preparation thereof which comprises the steps of (1) condensing a compound of the formula <FORM:0893921/IV (b)/2> wherein R and R1 are as defined above with a lower alkyl oxalate, lower alkyl formate or a lower alkyl trifluoroacetate, in the presence of a basic condensation catalyst to produce a 21-carbonyl substituted compound, halogenating the thus produced compound with chlorine or bromine to produce a 21,21-dihalo compound and (3) reacting the 21,21-dihalo compound with an alkali-metal alkoxide to obtain the desired product. Specifications 893,922 and 893,923 are referred to.
GB14614/60A 1959-06-04 1960-04-26 Improvements in or relating to steroids and the manufacture thereof Expired GB893921A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US893921XA 1959-06-04 1959-06-04

Publications (1)

Publication Number Publication Date
GB893921A true GB893921A (en) 1962-04-18

Family

ID=22217398

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14614/60A Expired GB893921A (en) 1959-06-04 1960-04-26 Improvements in or relating to steroids and the manufacture thereof

Country Status (1)

Country Link
GB (1) GB893921A (en)

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