GB893921A - Improvements in or relating to steroids and the manufacture thereof - Google Patents

Improvements in or relating to steroids and the manufacture thereof

Info

Publication number
GB893921A
GB893921A GB14614/60A GB1461460A GB893921A GB 893921 A GB893921 A GB 893921A GB 14614/60 A GB14614/60 A GB 14614/60A GB 1461460 A GB1461460 A GB 1461460A GB 893921 A GB893921 A GB 893921A
Authority
GB
United Kingdom
Prior art keywords
compound
lower alkyl
carbon atoms
formula
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14614/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB893921A publication Critical patent/GB893921A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a compound having the formula <FORM:0893921/IV (b)/1> wherein R is fluorine or lower alkyl (1-8 carbon atoms) and R1 is lower alkylene (2-3 carbon atoms) and a process for the preparation thereof which comprises the steps of (1) condensing a compound of the formula <FORM:0893921/IV (b)/2> wherein R and R1 are as defined above with a lower alkyl oxalate, lower alkyl formate or a lower alkyl trifluoroacetate, in the presence of a basic condensation catalyst to produce a 21-carbonyl substituted compound, halogenating the thus produced compound with chlorine or bromine to produce a 21,21-dihalo compound and (3) reacting the 21,21-dihalo compound with an alkali-metal alkoxide to obtain the desired product. Specifications 893,922 and 893,923 are referred to.
GB14614/60A 1959-06-04 1960-04-26 Improvements in or relating to steroids and the manufacture thereof Expired GB893921A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US893921XA 1959-06-04 1959-06-04

Publications (1)

Publication Number Publication Date
GB893921A true GB893921A (en) 1962-04-18

Family

ID=22217398

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14614/60A Expired GB893921A (en) 1959-06-04 1960-04-26 Improvements in or relating to steroids and the manufacture thereof

Country Status (1)

Country Link
GB (1) GB893921A (en)

Similar Documents

Publication Publication Date Title
GB893921A (en) Improvements in or relating to steroids and the manufacture thereof
GB1091027A (en) Production of quinacridones
GB841745A (en) Production of aliphatic bromides
GB1103075A (en) Processes for the preparation of 19-nor-steroids
GB565976A (en) Process for the manufacture of crystalline sodium-d-pantothenate
GB742450A (en) Improvements in or relating to piperazine derivatives and process of preparing the same
GB1474867A (en) Process for the preparation of 2,2,2-trichloroethyl chloro formate
GB1067346A (en) Novel seco-steroid compounds, processes for preparing them and compositions containing them
ES306520A1 (en) A procedure to prepare a adduct. (Machine-translation by Google Translate, not legally binding)
PT77580A (en) Process for preparing 1,1-dioxopenicillaoiloxymethyl 6-beta-aminopenicillanate and intermediates thereof
GB1062386A (en) Process for preparing pyrazinyl phosphorothioates
GB893923A (en) Movements in or relating to steroids and the manufacture thereof
GB1011116A (en) Process of producing a 1-halo-1-nitroalkane, and 1-halo-1-nitroalkanes produced by the process
GB746096A (en) Production of -a-(n-(-a-diethylaminoethyl))-aminophenylacetic acid isoamyl ester hydrochloride
GB948882A (en) Process for preparing borazoles
GB835860A (en) A method of producing pharmaceutically active tropinyl ethers
GB612222A (en) Manufacture of acedianthrone derivatives
GB605916A (en) The manufacture of substituted benzhydryl ethers
GB672164A (en) A process for the manufacture of pentaenes
GB856857A (en) Method of producing boron trialkyls
GB616309A (en) Improvements in or relating to the preparation of o-tolyl ethers
GB686135A (en) Improvements in cyclopentanophenanthrene derivatives and process for producing the same
GB966835A (en) The preparation of 1,4-cyclohexadiene-1,4-dicarboxylic acid
GB853783A (en) New piperazine derivatives and process for the preparation thereof
GB999398A (en) New esters of the yohimbane series and process for their manufacture