GB565976A - Process for the manufacture of crystalline sodium-d-pantothenate - Google Patents

Process for the manufacture of crystalline sodium-d-pantothenate

Info

Publication number
GB565976A
GB565976A GB7139/42A GB713942A GB565976A GB 565976 A GB565976 A GB 565976A GB 7139/42 A GB7139/42 A GB 7139/42A GB 713942 A GB713942 A GB 713942A GB 565976 A GB565976 A GB 565976A
Authority
GB
United Kingdom
Prior art keywords
pantothenate
alcohol
sodium
manufacture
butyrolactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7139/42A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB565976A publication Critical patent/GB565976A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Crystalline sodium d-pantothenate is obtained by reacting the sodium salt of b -alanine with (-)-a -hydroxy - b : b - dimethyl-g -butyrolactone by heating under anhydrous conditions, and crystallising the fused product from a solution in an aliphatic alcohol, having not more than three atoms of carbon in the molecule. The reaction itself may also be effected in the presence of the alcohol. In examples, the sodium salt of b -alanine is refluxed in ethyl and isopropyl alcohol with (-)-a -hydroxy-b : b -dimethyl-g -butyrolactone and the sodium d-pantothenate crystallised out after filtration. In a further example, the reactants are fused together and the product dissolved in ethyl alcohol and crystallised. Reference has been directed by the Comptroller to Specification 552,581.
GB7139/42A 1941-05-26 1942-05-26 Process for the manufacture of crystalline sodium-d-pantothenate Expired GB565976A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US565976XA 1941-05-26 1941-05-26

Publications (1)

Publication Number Publication Date
GB565976A true GB565976A (en) 1944-12-07

Family

ID=22005472

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7139/42A Expired GB565976A (en) 1941-05-26 1942-05-26 Process for the manufacture of crystalline sodium-d-pantothenate

Country Status (1)

Country Link
GB (1) GB565976A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2426042A1 (en) * 1978-05-18 1979-12-14 Hoffmann La Roche PROCESS FOR PREPARING SODIUM PANTOTHENATE
CN110105235A (en) * 2019-05-31 2019-08-09 珠海润都制药股份有限公司 A kind of preparation method of high-purity sodium pantothenate
CN111072512A (en) * 2019-11-13 2020-04-28 合肥华方医药科技有限公司 Preparation and detection method of high-purity high-melting-point sodium pantothenate
CN112321447A (en) * 2020-09-27 2021-02-05 安徽泰格生物科技有限公司 Method for preparing D-sodium pantothenate from D-calcium pantothenate mother liquor

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2426042A1 (en) * 1978-05-18 1979-12-14 Hoffmann La Roche PROCESS FOR PREPARING SODIUM PANTOTHENATE
CN110105235A (en) * 2019-05-31 2019-08-09 珠海润都制药股份有限公司 A kind of preparation method of high-purity sodium pantothenate
CN110105235B (en) * 2019-05-31 2022-07-08 珠海润都制药股份有限公司 Preparation method of high-purity sodium pantothenate
CN111072512A (en) * 2019-11-13 2020-04-28 合肥华方医药科技有限公司 Preparation and detection method of high-purity high-melting-point sodium pantothenate
CN111072512B (en) * 2019-11-13 2022-11-15 合肥华方医药科技有限公司 Preparation and detection method of high-purity high-melting-point sodium pantothenate
CN112321447A (en) * 2020-09-27 2021-02-05 安徽泰格生物科技有限公司 Method for preparing D-sodium pantothenate from D-calcium pantothenate mother liquor

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