GB770728A - Improvements in or relating to process for preparing 1-benzamido-1-phenyl-3-piperidinopropane - Google Patents

Improvements in or relating to process for preparing 1-benzamido-1-phenyl-3-piperidinopropane

Info

Publication number
GB770728A
GB770728A GB1527155A GB1527155A GB770728A GB 770728 A GB770728 A GB 770728A GB 1527155 A GB1527155 A GB 1527155A GB 1527155 A GB1527155 A GB 1527155A GB 770728 A GB770728 A GB 770728A
Authority
GB
United Kingdom
Prior art keywords
phenyl
piperidinopropane
benzamido
relating
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1527155A
Inventor
Albert Pohland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to GB1527155A priority Critical patent/GB770728A/en
Publication of GB770728A publication Critical patent/GB770728A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1 - Benzamido - 1 - phenyl - 3 - piperidinopropane is made by reacting 1-phenyl-3-piperidinopropanol with benzonitrile in the presence of concentrated sulphuric acid at a temperature of 30 DEG to 100 DEG C., preferably between 50 DEG and 60 DEG C. If desired, the reaction may be carried out in a solvent such as glacial acetic acid. The product may be purified either via a crystalline salt such as the hydrochloride or by recrystallization of the free base.
GB1527155A 1955-05-26 1955-05-26 Improvements in or relating to process for preparing 1-benzamido-1-phenyl-3-piperidinopropane Expired GB770728A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1527155A GB770728A (en) 1955-05-26 1955-05-26 Improvements in or relating to process for preparing 1-benzamido-1-phenyl-3-piperidinopropane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1527155A GB770728A (en) 1955-05-26 1955-05-26 Improvements in or relating to process for preparing 1-benzamido-1-phenyl-3-piperidinopropane

Publications (1)

Publication Number Publication Date
GB770728A true GB770728A (en) 1957-03-20

Family

ID=10056085

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1527155A Expired GB770728A (en) 1955-05-26 1955-05-26 Improvements in or relating to process for preparing 1-benzamido-1-phenyl-3-piperidinopropane

Country Status (1)

Country Link
GB (1) GB770728A (en)

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