GB883282A - New guanidine compounds - Google Patents

New guanidine compounds

Info

Publication number
GB883282A
GB883282A GB19907/59A GB1990759A GB883282A GB 883282 A GB883282 A GB 883282A GB 19907/59 A GB19907/59 A GB 19907/59A GB 1990759 A GB1990759 A GB 1990759A GB 883282 A GB883282 A GB 883282A
Authority
GB
United Kingdom
Prior art keywords
octahydro
ethyl
carbon atoms
prepared
azoninyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19907/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB883282A publication Critical patent/GB883282A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises alkyleneiminoalkylguanidines in which the alkyleneimino ring contains from 4 to 10 carbon atoms and the alkyl radical contains from 1 to 7 carbon atoms, acyl derivatives thereof and also their physiologically tolerable acid addition and quaternary ammonium salts. The guanidino group is preferably unsubstituted, but may bear lower hydrocarbon radicals on the nitrogen atoms. Acyl derivates may be formed with organic acids (many listed), including acetic, trifluoroacetic, hydroxyacetic acrylic, aminobenzoic, nicotine and 2-furoic acid. The compounds are prepared by reacting an alkyleneimino alkylamine with an S-alkyl isothiourea or a salt thereof, preferably in the presence of a solvent. Examples detail the preparation of 2-(octahydro-1-azoninyl)-ethyl-guanidine sulphate and 3 - (octahydro - 1 - azocinyl) - propyl-, 2 - (hexahydro - 1 - azepinyl) - ethyl-, 2-(piperidino) ethyl- and 2-(decamethyleneimino) ethyl guanidine sulphate. 2-(Octahydro-1-azoninyl)-ethylamine is prepared by lithium aluminium hydride reduction of octahydro - 1 - azoninyl - acetonitrile itself formed from chloracetonitrile and octahydro-azonine. 3 - (Octahydro - 1 - azocinyl) - propylamino is prepared from octahydro-azocine via octa-hydro-1-azocinyl-propionitrile. The other starting materials are likewise prepared. Specification 883,283 is referred to.ALSO:Hypotensive compositions comprise alkyleneiminoalkylguanidines (in which the alkyleneimino ring contains from 4 to 10 carbon atoms and the alkyl radical contains from 1 to 7 carbon atoms), their N-acyl derivatives, and/or their physiologically tolerable acid addition or quaternary ammonium salts, together with a suitable carrier for enteral, particularly oral, or parenteral administration. The compositions may be in the form of tablets, dragees, capsules, solutions, suspensions or emulsions and may incorporate auxiliary agents or other therapeutic compounds.
GB19907/59A 1958-06-10 1959-06-10 New guanidine compounds Expired GB883282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74102058A 1958-06-10 1958-06-10

Publications (1)

Publication Number Publication Date
GB883282A true GB883282A (en) 1961-11-29

Family

ID=24979033

Family Applications (2)

Application Number Title Priority Date Filing Date
GB19907/59A Expired GB883282A (en) 1958-06-10 1959-06-10 New guanidine compounds
GB37788/59A Expired GB883283A (en) 1958-06-10 1959-06-10 A new guanidine compound

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB37788/59A Expired GB883283A (en) 1958-06-10 1959-06-10 A new guanidine compound

Country Status (5)

Country Link
CY (1) CY255A (en)
FR (2) FR221M (en)
GB (2) GB883282A (en)
MY (1) MY6300008A (en)
OA (1) OA01798A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531089B1 (en) * 1982-07-27 1986-03-21 Pharmascience Lab NOVEL OESTRANIC DERIVATIVES FOR TOPICAL PHARMACOLOGICAL APPLICATIONS AND THEIR PREPARATION METHOD

Also Published As

Publication number Publication date
OA01798A (en) 1970-01-14
FR221M (en) 1961-02-27
CY255A (en) 1962-12-03
GB883283A (en) 1961-11-29
MY6300008A (en) 1963-12-31
FR307M (en) 1961-03-20

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