GB990092A - Novel indole derivatives and a process for the manufacture thereof - Google Patents

Novel indole derivatives and a process for the manufacture thereof

Info

Publication number
GB990092A
GB990092A GB4025562A GB4025562A GB990092A GB 990092 A GB990092 A GB 990092A GB 4025562 A GB4025562 A GB 4025562A GB 4025562 A GB4025562 A GB 4025562A GB 990092 A GB990092 A GB 990092A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
indole
methyl
ethyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4025562A
Inventor
Aaron Cohen
Basil Heath-Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Priority to GB4025562A priority Critical patent/GB990092A/en
Publication of GB990092A publication Critical patent/GB990092A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention comprises compounds of general formula <FORM:0990092/C2/1> wherein R1 stands for a halogen atom or a methoxy, ethoxy, methyl or ethyl group, and R2 and R3 each stand for a methyl or ethyl group, and wherein the bonds shown as broken lines denote that the substituents attached thereby are optional; and their acid addition salts; and their preparation (1) by reducing corresponding 3 - (b - nitro - alkyl) - indoles with zinc dust in the presence of aqueous ammonium chloride, or (2) when R1 is not halogen and R2 is absent, by reacting a corresponding 3-(b -keto-alkyl)-indole with hydroxylamine forming a 3-(b -hydroxylimino-alkyl)-indole which is then catalytically reduced. Pharmaceutical compositions comprise compounds of the invention with carriers. Enteral and parenteral administration of tablets, capsules, dragees, suppositories, solutions, emulsions and suspensions is mentioned. The compounds are appetite suppressants.
GB4025562A 1962-10-24 1962-10-24 Novel indole derivatives and a process for the manufacture thereof Expired GB990092A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4025562A GB990092A (en) 1962-10-24 1962-10-24 Novel indole derivatives and a process for the manufacture thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4025562A GB990092A (en) 1962-10-24 1962-10-24 Novel indole derivatives and a process for the manufacture thereof

Publications (1)

Publication Number Publication Date
GB990092A true GB990092A (en) 1965-04-22

Family

ID=10413983

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4025562A Expired GB990092A (en) 1962-10-24 1962-10-24 Novel indole derivatives and a process for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB990092A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947584A (en) * 1972-09-15 1976-03-30 Siegfried Aktiengesellschaft Novel indolyl alkyl amines, method of producing same, and their use as anorectic agents
CN113548975A (en) * 2021-06-10 2021-10-26 宁波职业技术学院 Preparation method of 4-aminonaphthalene-2, 6-dicarboxylic acid
US11591353B2 (en) 2020-02-04 2023-02-28 Mindset Pharma Inc. Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
US11746087B1 (en) 2022-03-18 2023-09-05 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947584A (en) * 1972-09-15 1976-03-30 Siegfried Aktiengesellschaft Novel indolyl alkyl amines, method of producing same, and their use as anorectic agents
US11591353B2 (en) 2020-02-04 2023-02-28 Mindset Pharma Inc. Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
US12054505B2 (en) 2020-02-04 2024-08-06 Mindset Pharma Inc. Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
CN113548975A (en) * 2021-06-10 2021-10-26 宁波职业技术学院 Preparation method of 4-aminonaphthalene-2, 6-dicarboxylic acid
US11746087B1 (en) 2022-03-18 2023-09-05 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
US12065404B2 (en) 2022-03-18 2024-08-20 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
US12077498B2 (en) 2022-03-18 2024-09-03 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using

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